HCK and SF3B3

Number of citations of the paper that reports this interaction (PMID 12029088)
18

Data Source:
HPRD (in vitro)

		HCK	SF3B3
Gene Name		HCK proto-oncogene, Src family tyrosine kinase	splicing factor 3b, subunit 3, 130kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Lysosome Golgi Apparatus Cytosol Actin Filament Caveola Focal Adhesion Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection	Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Small Nuclear Ribonucleoprotein Complex Catalytic Step 2 Spliceosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	RNA Binding Protein Binding
	Biological Process	Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signal Transduction Protein Phosphorylation Inflammatory Response Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Viral Process Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Leukocyte Degranulation Innate Immune Response Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Defense Response To Virus By Virus Regulation Of Inflammatory Response Regulation Of Phagocytosis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Podosome Assembly Positive Regulation Of Actin Cytoskeleton Reorganization	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing Protein Complex Assembly RNA Splicing Gene Expression
Pathways		HIV Infection Host Interactions of HIV factors Cytokine Signaling in Immune system The role of Nef in HIV-1 replication and disease pathogenesis Nef and signal transduction Signaling by Interleukins Regulation of signaling by CBL Fcgamma receptor (FCGR) dependent phagocytosis Interleukin-3, 5 and GM-CSF signaling FCGR activation Innate Immune System	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs		1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		69 interactors: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK C2orf44 CBL CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A GOPC HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 MAP4K5 MTUS2 NOTCH2NL PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TRPV4 TSG101 UNC119 VAV1 WAS WIPF1 WNT2	27 interactors: APBB1 EFTUD2 EPS8 ERG HCK HGS HSPB1 KLF10 MPP3 NAGK NOL12 OSGEP PPIL1 PRPF40A RAD9A RBM6 RUFY2 SF3B1 SMAD5 SREK1 TAF9 TCERG1 TOE1 WBP4 WWOX YWHAG ZNF579
Entrez ID		3055	23450
HPRD ID		00796	12027
Ensembl ID		ENSG00000101336
Uniprot IDs		A8K4G3 P08631	A8K6V3 Q15393
PDB IDs		1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 5HCK
Enriched GO Terms of Interacting Partners?		Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Blood Coagulation Response To Stimulus Defense Response Regulation Of Immune Response Hemostasis Wound Healing Immune System Process Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Antigen Receptor-mediated Signaling Pathway Response To Wounding Positive Regulation Of Immune Response Phagocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Body Fluid Levels Locomotion Regulation Of Immune System Process T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Vesicle-mediated Transport Response To Stress Regulation Of Signal Transduction Regulation Of Cellular Process Platelet Activation Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Signaling Response To External Stimulus Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process	RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Shape Regulation Of Cell Death Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Process Response To Transforming Growth Factor Beta Positive Regulation Of Apoptotic Signaling Pathway Respiratory Burst After Phagocytosis Negative Regulation Of Thymidylate Synthase Biosynthetic Process Negative Regulation Of Potassium Ion Export Cardiac Muscle Contraction Regulation Of Transcription From RNA Polymerase II Promoter Metabolic Process Heart Contraction Positive Regulation Of Response To DNA Damage Stimulus Peptidyl-amino Acid Modification Threonylcarbamoyladenosine Biosynthetic Process Leukocyte Migration Involved In Immune Response Regulation Of Heart Rate By Hormone N-acetylmannosamine Metabolic Process Response To Organic Substance Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Ossification Response To Growth Factor Positive Regulation Of Cell Death Actin Polymerization-dependent Cell Motility Striated Muscle Contraction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway N-acetylneuraminate Catabolic Process
Tagcloud ?		32dcl3 32p antisera cbl eliminated engagement fusion fyn gst immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	advance albeit ascertain atlas cohorts document doi dx endocrine fulvestrant lcc2 lcc9 mcf modern modpathol november oncotype online paraffin parts publication publicly qrt sets sf3b1 splicing tamoxifen
Tagcloud (Difference) ?		32dcl3 32p antisera cbl eliminated engagement fusion fyn gst immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	advance albeit ascertain atlas cohorts document doi dx endocrine fulvestrant lcc2 lcc9 mcf modern modpathol november oncotype online paraffin parts publication publicly qrt sets sf3b1 splicing tamoxifen
Tagcloud (Intersection) ?