GSN and PIK3CG

Number of citations of the paper that reports this interaction (PMID 11577104)
26

Data Source:
HPRD (in vivo, in vitro)

		GSN	PIK3CG
Gene Name		gelsolin	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Image
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Cytosol Focal Adhesion Actin Cytoskeleton Lamellipodium Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex, Class IB Membrane Mast Cell Granule
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Ephrin Receptor Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Aging Oligodendrocyte Development Vesicle-mediated Transport Actin Filament Polymerization Regulation Of Cell Adhesion Tissue Regeneration Actin Nucleation Response To Ethanol Phosphatidylinositol-mediated Signaling Actin Filament Severing Barbed-end Actin Filament Capping Response To Folic Acid Cilium Morphogenesis Cellular Response To Cadmium Ion	Angiogenesis Cytokine Production Adaptive Immune Response Dendritic Cell Chemotaxis Positive Regulation Of Acute Inflammatory Response Respiratory Burst Involved In Defense Response Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation T Cell Chemotaxis Negative Regulation Of Triglyceride Catabolic Process Phosphatidylinositol 3-kinase Signaling Platelet Activation Neutrophil Chemotaxis Secretory Granule Localization Regulation Of Cell Adhesion Mediated By Integrin Natural Killer Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process T Cell Proliferation T Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Cardiac Muscle Contraction Platelet Aggregation Neutrophil Extravasation Hepatocyte Apoptotic Process Negative Regulation Of Fibroblast Apoptotic Process
Pathways		Amyloids Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins	Synthesis of PIPs at the plasma membrane Signaling by GPCR GPCR downstream signaling Metabolism of lipids and lipoproteins G-protein beta:gamma signalling G beta:gamma signalling through PI3Kgamma GPVI-mediated activation cascade Phospholipid metabolism Platelet activation, signaling and aggregation PI Metabolism
Drugs			Staurosporine Myricetin 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One Quercetin 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Diseases
GWAS			Blood pressure ( 21909110) Carotid intima media thickness ( 21909108) Mean platelet volume ( 22139419 19820697 22423221) Platelet counts ( 22139419)
Protein-Protein Interactions		23 interactors: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CLIC5 CSK FHIT FN1 LIMK2 PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1	22 interactors: ADRBK1 BCR CD28 EPHA8 GAB1 GRB2 GSN HRAS IL6ST KIT KRAS LYN NOTCH1 NRAS PIK3CD PIK3R5 PTPN11 SEC14L2 SET SMPD2 TPM2 ZNF282
Entrez ID		2934	5294
HPRD ID		00674	03135
Ensembl ID		ENSG00000148180	ENSG00000105851
Uniprot IDs		B7Z4U6 B7Z5V1 F5H1A8 P06396	A8K9G9 P48736
PDB IDs		1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5	1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 3MJW 3ML8 3ML9 3NZS 3NZU 3OAW 3P2B 3PRE 3PRZ 3PS6 3QAQ 3QAR 3QJZ 3QK0 3R7Q 3R7R 3S2A 3SD5 3T8M 3TJP 3TL5 3ZVV 3ZW3 4ANU 4ANV 4ANW 4ANX 4AOF 4DK5 4EZJ 4EZK 4EZL 4F1S 4FA6 4FAD 4FHJ 4FHK 4FJY 4FJZ 4FLH 4FUL 4G11 4GB9 4HLE 4KZ0 4KZC
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Cell Junction Assembly Response To Wounding Regulation Of Body Fluid Levels Wound Healing Adherens Junction Organization Movement Of Cell Or Subcellular Component Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Response To Stimulus Response To Stress Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Cell Morphogenesis Regulation Of Kinase Activity Cell Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cell Differentiation Cellular Component Assembly Cell Projection Organization Signaling Anatomical Structure Development Generation Of Neurons Platelet Aggregation Cell Communication Positive Regulation Of Protein Metabolic Process Locomotion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Nervous System Development Developmental Process Multicellular Organismal Development Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neuron Differentiation System Development Regulation Of Cellular Component Organization Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Phosphatidylinositol-mediated Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Leukocyte Migration Regulation Of Intracellular Signal Transduction Innate Immune Response Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Immune Response Defense Response Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Response To External Stimulus Positive Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Cell Migration Wound Healing Regulation Of Catalytic Activity Chemotaxis Positive Regulation Of Phosphorylation Cell Motility Regulation Of Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Insulin Receptor Signaling Pathway Signal Transduction Regulation Of Phosphorylation Response To Wounding Regulation Of MAP Kinase Activity
Tagcloud ?		amyloidogenic amyloidosis autosomal contractility counter crossbreeding dermatological disturbed dominantly folding furin g2 g654a gelsolin generates hampered hereditary inherited mt1 nanobodies nanobody nb11 ophthalmological proteases proteolysis proteolytic rendering secreting shield	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk2 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides prostate proteases pseudogene repeats share silico talk
Tagcloud (Difference) ?		amyloidogenic amyloidosis autosomal contractility counter crossbreeding dermatological disturbed dominantly folding furin g2 g654a gelsolin generates hampered hereditary inherited mt1 nanobodies nanobody nb11 ophthalmological proteolysis proteolytic rendering secreting shield	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk2 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides prostate pseudogene repeats share silico talk
Tagcloud (Intersection) ?		proteases