PCSK1N and PCSK1

Number of citations of the paper that reports this interaction (PMID 11435430)
14

Data Source:
HPRD (in vitro)

		PCSK1N	PCSK1
Gene Name		proprotein convertase subtilisin/kexin type 1 inhibitor	proprotein convertase subtilisin/kexin type 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Trans-Golgi Network Secretory Granule Extracellular Vesicular Exosome	Extracellular Space Golgi Apparatus Transport Vesicle Secretory Granule Lumen
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Receptor Binding	Serine-type Endopeptidase Activity
	Biological Process	Response To Dietary Excess Neuropeptide Signaling Pathway Response To Cold Negative Regulation Of Endopeptidase Activity Peptide Hormone Processing	Proteolysis Cell-cell Signaling Metabolic Process Peptide Hormone Processing Peptide Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Insulin Secretion
Pathways			Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS			Body mass index ( 22344219) Fasting glucose-related traits (interaction with BMI) ( 22581228) Proinsulin levels ( 21873549)
Protein-Protein Interactions		1 interactors: PCSK1	4 interactors: IAPP PCSK1N PMCH REN
Entrez ID		27344	5122
HPRD ID		02320	01201
Ensembl ID		ENSG00000102109	ENSG00000175426
Uniprot IDs		Q9UHG2	P29120
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptide Biosynthetic Process Peptide Hormone Processing Peptide Metabolic Process Hormone Metabolic Process Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Secretion Regulation Of Hormone Levels	Feeding Behavior Peptide Hormone Processing Behavior Neuropeptide Signaling Pathway Peptide Metabolic Process Hormone Metabolic Process Protein Processing Renin-angiotensin Regulation Of Aldosterone Production Cellular Amide Metabolic Process Regulation Of Hormone Levels Drinking Behavior Response To CGMP Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Negative Regulation Of Bone Resorption Regulation Of Blood Volume By Renin-angiotensin Negative Regulation Of Bone Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Signal Transduction Negative Regulation Of Tissue Remodeling Response To Dietary Excess Signaling Cell Communication Beta-amyloid Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Immobilization Stress Negative Regulation Of Neuroblast Proliferation Eating Behavior Negative Regulation Of Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway Regulation Of Bone Resorption Negative Regulation Of Stem Cell Proliferation Cellular Response To Stimulus Regulation Of Bone Remodeling Cell-cell Signaling Negative Regulation Of Neural Precursor Cell Proliferation Endocrine Pancreas Development Regulation Of Neuroblast Proliferation Cellular Response To Drug Response To Cold Regulation Of Tissue Remodeling G-protein Coupled Receptor Signaling Pathway
Tagcloud ?			accompanied beneficial beta ccnd2 critical d2 elucidation glut2 granuphilin impaired islets knockout mafa maturation pancreatic pool postnatal prlr prolactin regulates resulted secreting stat5b transactivated transcriptome translocation urocortin vdr znt8
Tagcloud (Difference) ?			accompanied beneficial beta ccnd2 critical d2 elucidation glut2 granuphilin impaired islets knockout mafa maturation pancreatic pool postnatal prlr prolactin regulates resulted secreting stat5b transactivated transcriptome translocation urocortin vdr znt8
Tagcloud (Intersection) ?