DISC1 and KIFAP3

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		DISC1	KIFAP3
Gene Name		disrupted in schizophrenia 1	kinesin-associated protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane	Condensed Nuclear Chromosome Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Spindle Microtubule Axoneme Microtubule Cytoskeleton Kinesin II Complex Intraciliary Transport Particle Photoreceptor Connecting Cilium Ciliary Basal Body Extracellular Vesicular Exosome Primary Cilium Ciliary Tip Periciliary Membrane Compartment
	Molecular Function	Protein Binding	Protein Binding Kinesin Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Protein Complex Assembly Organelle Organization Microtubule-based Process Microtubule-based Movement Signal Transduction Blood Coagulation Protein Localization Negative Regulation Of Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Apoptotic Process Positive Regulation Of Calcium-dependent Cell-cell Adhesion Membrane Organization Plus-end-directed Vesicle Transport Along Microtubule
Pathways			Organelle biogenesis and maintenance MHC class II antigen presentation Kinesins Translocation of GLUT4 to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Intraflagellar transport Adaptive Immune System
Drugs
Diseases
GWAS		Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)	Amyotrophic lateral sclerosis ( 19451621)
Protein-Protein Interactions		113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365	18 interactors: APC AR DISC1 KIF3B MAP3K10 MAP3K11 MEST MINK1 NAA10 NCF2 NIPSNAP3A NUDT21 PEX19 RAP1GDS1 RBFOX1 RPGR SMC3 SRC
Entrez ID		27185	22920
HPRD ID		05553	03499
Ensembl ID		ENSG00000162946	ENSG00000075945
Uniprot IDs		C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5	Q92845
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization	Organelle Organization Cytoskeleton Organization Microtubule-based Process Activation Of JNKK Activity Protein Autophosphorylation JNK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of MAPK Cascade Mitochondrial Calcium Ion Homeostasis Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Cellular Component Assembly Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Positive Regulation Of MAPK Cascade Microtubule Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Stress-activated MAPK Cascade Regulation Of Apoptotic Process Activation Of JUN Kinase Activity Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of MAP Kinase Activity Mitotic Spindle Organization Regulation Of Cell Death MAPK Cascade Response To Progesterone Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Integrin Biosynthetic Process Negative Regulation Of Lipid Binding Positive Regulation Of Neuron Apoptotic Process Activation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of Metabolic Process T Cell Differentiation In Thymus Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility	als amyotrophic angiogenin contributors decade deterioration determinant devastating directions discoveries extends extensively familial fifth fus incurable lifespan linking occurs progresses prolong riluzole sod1 sought sporadic therapeutics tls typically unc13a
Tagcloud (Difference) ?		accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility	als amyotrophic angiogenin contributors decade deterioration determinant devastating directions discoveries extends extensively familial fifth fus incurable lifespan linking occurs progresses prolong riluzole sod1 sought sporadic therapeutics tls typically unc13a
Tagcloud (Intersection) ?