KAT2A and GATA2

Number of citations of the paper that reports this interaction (PMID 15001660)
23

Data Source:
BioGRID (enzymatic study)

		KAT2A	GATA2
Gene Name		K(lysine) acetyltransferase 2A	GATA binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex STAGA Complex Transcription Factor TFTC Complex Mitotic Spindle	Nucleoplasm Protein Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific)	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Enhancer Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding C2H2 Zinc Finger Domain Binding
	Biological Process	In Utero Embryonic Development Somitogenesis Neural Tube Closure Chromatin Organization Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Viral Process Histone Deubiquitination Telencephalon Development Metencephalon Development Midbrain Development Regulation Of Protein Stability Multicellular Organism Growth Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Urogenital System Development Cell Fate Determination Embryonic Placenta Development Transcription, DNA-templated Phagocytosis Blood Coagulation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Pituitary Gland Development Somatic Stem Cell Maintenance Regulation Of Histone Acetylation Eosinophil Fate Commitment Inner Ear Morphogenesis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Definitive Hemopoiesis Semicircular Canal Development Negative Regulation Of Fat Cell Proliferation GABAergic Neuron Differentiation Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Forebrain Neuron Differentiation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HATs acetylate histones Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Chromatin organization RNA Polymerase I Transcription Signaling by NOTCH Notch-HLH transcription pathway NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Eosinophil counts ( 19198610) White blood cell count ( 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		45 interactors: ATXN7 BATF2 BRCA1 CDK2 CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 GATA2 HIST1H1B HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HIST4H4 HSD11B2 IRF1 IRF2 IRF7 MYB MYC NOTCH1 PBX1 PPARG PRKDC PYGO2 RBPJ RELA SIRT2 SUMO1 TACC1 TACC2 TACC3 TADA2A TCF3 TRRAP XRCC6	34 interactors: ADAMTSL4 AKT1 CEBPA EP300 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 LMO2 MAPK1 MDFI NOTCH2NL PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1
Entrez ID		2648	2624
HPRD ID		03807	00673
Ensembl ID		ENSG00000108773	ENSG00000179348
Uniprot IDs		Q92830	P23769
PDB IDs		1F68 1Z4R 3D7C
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Gene Expression Cell Cycle Chromatin Organization Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Chromatin Silencing At RDNA Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Type I Interferon Production Organelle Organization Regulation Of Metabolic Process Immune System Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Negative Regulation Of Cell Differentiation Chromatin Modification DNA Methylation On Cytosine Response To Abiotic Stimulus Regulation Of Histone Modification Chromatin Silencing Regulation Of Chromosome Organization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Organ Development Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Hemopoiesis Immune System Development Embryo Development System Development Multicellular Organismal Development Biosynthetic Process Immune System Process Cellular Nitrogen Compound Metabolic Process Cardiovascular System Development Gland Development Regulation Of Metabolic Process Myeloid Cell Differentiation Regulation Of Binding Developmental Process Anatomical Structure Development Nitrogen Compound Metabolic Process Regulation Of Cell Differentiation Protein Localization To Nucleus Regulation Of Myeloid Cell Differentiation Nucleobase-containing Compound Metabolic Process Tissue Development
Tagcloud ?		acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast	arises begins betah1 commitment conceptus conceptuses e7 e8 ectodermal erythroblasts erythropoiesis extraembryonic gastrulation globin headfold islands mesoderm morphologically ordered primitive proceeds rbtn2 recognizable sac somite streak vys yolk
Tagcloud (Difference) ?		acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast	arises begins betah1 commitment conceptus conceptuses e7 e8 ectodermal erythroblasts erythropoiesis extraembryonic gastrulation globin headfold islands mesoderm morphologically ordered primitive proceeds rbtn2 recognizable sac somite streak vys yolk
Tagcloud (Intersection) ?