RCHY1 and ARF4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		RCHY1	ARF4
Gene Name		ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase	ADP-ribosylation factor 4
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Golgi Apparatus Cytosol Membrane Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Homodimerization Activity	GTPase Activity Epidermal Growth Factor Receptor Binding Protein Binding GTP Binding
	Biological Process	Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination	Protein ADP-ribosylation Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Brain Development Protein Transport Vesicle-mediated Transport Cell Migration Activation Of Phospholipase D Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Axon Injury Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium
Drugs
Diseases
GWAS		Response to tocilizumab in rheumatoid arthritis ( 22491018)
Protein-Protein Interactions		61 interactors: ADAMTSL4 AIG1 AOX1 AR ARF4 ATN1 BIRC3 C19orf80 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CYBA DCUN1D5 F7 FADS6 GFI1B GORAB HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NL PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBE2D2 UBE2D4 WDR74 ZNF160	6 interactors: ADRB2 EGFR HNRNPD RAB11FIP3 RCHY1 SDCBP2
Entrez ID		25898	378
HPRD ID		07607	03107
Ensembl ID		ENSG00000163743	ENSG00000168374
Uniprot IDs		C7E542 E7EMC8 E7ETW5 J3KPI0 Q96PM5	P18085
PDB IDs		2JRJ 2K2C 2K2D	1Z6X
Enriched GO Terms of Interacting Partners?		Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Response To Gamma Radiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Protein Metabolic Process Cellular Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process Cellular Response To DNA Damage Stimulus Cell Cycle Process Positive Regulation Of Metabolic Process Cell Death Death Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process Response To Abiotic Stimulus Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Negative Regulation Of Programmed Cell Death	Regulation Of Vasodilation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Alkanesulfonate Metabolic Process Positive Regulation Of Protein Ubiquitination Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Cellular Protein Metabolic Process Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Circadian Rhythm Regulation Of Protein Metabolic Process Activation Of Phospholipase A2 Activity Positive Regulation Of Protein Modification Process Regulation Of Protein Ubiquitination Endosomal Transport Positive Regulation Of Phospholipase A2 Activity Cellular Localization Response To Cobalamin Response To UV-A Circadian Regulation Of Translation Heat Generation Response To Hydroxyisoflavone Diet Induced Thermogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Activation Of Protein Kinase Activity Rhythmic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Catenin Import Into Nucleus Regulation Of Phospholipase A2 Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Superoxide Anion Generation Magnesium Ion Homeostasis Negative Regulation Of Smooth Muscle Contraction Regulation Of Protein Catabolic Process Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Response To Dietary Excess Intracellular Transport Response To Nutrient Levels Positive Regulation Of Gene Expression Cellular Response To Estradiol Stimulus Positive Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Multicellular Organism Growth Protein Insertion Into Membrane
Tagcloud ?		20s alters animal conserved correlatively crucial degradation display e3 establish handful homeodomain hox hoxa2 interacts ligase modes multitude pirh2 promotes proteasomal proteasome regulators reports reveal stabilization subunits ubiquitin ubiquitination	apparatus arf1 arf3 arf5 arf6 arfs carrier coated complementary endocytic endocytosed endosomes former furin golgi gtpases localize overlapping pair recycling redundantly retrograde ribosylation tgn tgn38 transferrin trigger tubulation
Tagcloud (Difference) ?		20s alters animal conserved correlatively crucial degradation display e3 establish handful homeodomain hox hoxa2 interacts ligase modes multitude pirh2 promotes proteasomal proteasome regulators reports reveal stabilization subunits ubiquitin ubiquitination	apparatus arf1 arf3 arf5 arf6 arfs carrier coated complementary endocytic endocytosed endosomes former furin golgi gtpases localize overlapping pair recycling redundantly retrograde ribosylation tgn tgn38 transferrin trigger tubulation
Tagcloud (Intersection) ?