FTL and MAP3K12

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FTL	MAP3K12
Gene Name		ferritin, light polypeptide	mitogen-activated protein kinase kinase kinase 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Intracellular Ferritin Complex Membrane Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Axon Growth Cone
	Molecular Function	Iron Ion Binding Protein Binding Ferric Iron Binding Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity
	Biological Process	Iron Ion Transport Cellular Iron Ion Homeostasis Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Iron Ion Homeostasis Transmembrane Transport Membrane Organization	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways		Iron uptake and transport Golgi Associated Vesicle Biogenesis Scavenging by Class A Receptors trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs		Iron Dextran Protoporphyrin Ix
Diseases
GWAS
Protein-Protein Interactions		24 interactors: CLEC4G FTH1 GADD45A GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MPHOSPH6 MPP6 MYOC MYOG PIK3CA PPP1CC PTN RAP2A SDCBP SMAD9 SPINK7 TAF10 USHBP1 VKORC1 ZDHHC17	15 interactors: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP RGS1 RPL18A SH3RF1 TGM2 TSC22D1
Entrez ID		2512	7786
HPRD ID		00616	02709
Ensembl ID		ENSG00000087086	ENSG00000139625
Uniprot IDs		P02792	Q12852
PDB IDs		2FFX 2FG4 2FG8 3HX2 3HX5 3HX7 3KXU
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Muscle System Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Maturation Of 5.8S RRNA Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Response To Abiotic Stimulus Signaling Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Cell Communication ERBB Signaling Pathway Regulation Of JNK Cascade Blood Coagulation Hemostasis Regulation Of Stress-activated MAPK Cascade Response To Radiation Platelet Activation Membrane Organization Positive Regulation Of Phosphorylation Regulation Of Signaling Intracellular Signal Transduction Neural Plate Formation Skeletal Muscle Hypertrophy Positive Regulation Of Muscle Atrophy ERBB2-ERBB3 Signaling Pathway Ras Protein Signal Transduction Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Cellular Component Assembly Bone Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Ionizing Radiation Regulation Of Body Fluid Levels Hypomethylation Of CpG Island Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Intracellular Sequestering Of Iron Ion Serotonin Uptake ERBB2 Signaling Pathway Lactate Biosynthetic Process From Pyruvate Viral Penetration Into Host Nucleus Positive Regulation Of Metabolic Process	MAPK Cascade Signal Transduction By Phosphorylation Regulation Of JNK Cascade Regulation Of MAPK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Catalytic Activity Activation Of JUN Kinase Activity Cellular Response To Sorbitol Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Death Positive Regulation Of Transferase Activity Positive Regulation Of Apoptotic Process Activation Of Protein Kinase Activity Positive Regulation Of Programmed Cell Death Cellular Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Death Cellular Protein Metabolic Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of JNK Cascade
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	adipocytes adipogenesis adipogenic adipose ascs bisphenol bpa ccaat cebpa disrupter dlk dye ebpalpha esr1 ici igf1 leucine lipase lpl peroxisome physiologically pparg ppargamma precursors proliferator retained temporally visualize zipper
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1	adipocytes adipogenesis adipogenic adipose ascs bisphenol bpa ccaat cebpa disrupter dlk dye ebpalpha esr1 ici igf1 leucine lipase lpl peroxisome physiologically pparg ppargamma precursors proliferator retained temporally visualize zipper
Tagcloud (Intersection) ?