NCAPH and H2AFZ

Number of citations of the paper that reports this interaction (PMID 21633354)
36

Data Source:
BioGRID (pull down)

		NCAPH	H2AFZ
Gene Name		non-SMC condensin I complex, subunit H	H2A histone family, member Z
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensin Complex Nucleus Cytoplasm Cytosol Membrane	Nucleosome Barr Body Nucleus Nuclear Euchromatin Nuclear Heterochromatin Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Mitotic Chromosome Condensation Cell Division	Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estradiol Stimulus
Pathways		Mitotic Prometaphase Cell Cycle, Mitotic M Phase Condensation of Prometaphase Chromosomes	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: AURKB CAPG CDK1 H2AFZ HIST2H2AC NCAPD2	3 interactors: INCENP MAGEC1 NCAPH
Entrez ID		23397	3015
HPRD ID		03820	00823
Ensembl ID		ENSG00000121152	ENSG00000164032
Uniprot IDs		B4DRG7 B4E189 Q15003	P0C0S5
PDB IDs			1F66
Enriched GO Terms of Interacting Partners?		Chromosome Condensation Mitotic Nuclear Division Cell Division Protein Localization To Kinetochore Protein Localization To Chromosome, Centromeric Region DNA Packaging Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Chromosome Condensation Chromosome Segregation Protein Localization To Chromosome DNA Conformation Change Histone Phosphorylation Chromosome Organization Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Negative Regulation Of Protein Complex Disassembly Pronuclear Fusion Regulation Of Protein Depolymerization Peptidyl-serine Phosphorylation Regulation Of Protein Complex Disassembly Negative Regulation Of Cytoskeleton Organization Histone H3-S28 Phosphorylation Spindle Stabilization Cell Cycle Checkpoint Abscission Protein Complex Assembly DNA Metabolic Process Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Regulation Of Schwann Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Spindle Elongation Positive Regulation Of Cell Cycle Negative Regulation Of Cytokinesis Spindle Midzone Assembly Aging Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Protein Import Into Nucleus, Translocation Organelle Organization Histone Modification Histone-serine Phosphorylation Regulation Of Protein Import Into Nucleus, Translocation Mitotic G2 DNA Damage Checkpoint Regulation Of B Cell Apoptotic Process	Chromosome Segregation Mitotic Nuclear Division Cell Division Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Mitotic Chromosome Condensation Cell Cycle Chromosome Condensation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cytokinesis DNA Packaging Organelle Organization DNA Conformation Change
Tagcloud ?		annotations birc5 cdca2 cdh3 cited1 dhfr esco2 gins1 gins4 hells mc1r melana melanocyte melanocytes melk msg ncapg ncapg2 nusap1 oca2 pax3 pbk rad54l recapitulate revolutionized segregating subclasses tyms unsupervised	adrbk1 bisulfite ccne2 chimpanzee crabp1 cxcl6 derive dsc2 ega embryos endangered gapdh glut1 h3k27 h4k5 interspecies iscnt klf4 lin28 nanog oct4 ooplasm ptger4 remodel scnt soon stella usf2 utp
Tagcloud (Difference) ?		annotations birc5 cdca2 cdh3 cited1 dhfr esco2 gins1 gins4 hells mc1r melana melanocyte melanocytes melk msg ncapg ncapg2 nusap1 oca2 pax3 pbk rad54l recapitulate revolutionized segregating subclasses tyms unsupervised	adrbk1 bisulfite ccne2 chimpanzee crabp1 cxcl6 derive dsc2 ega embryos endangered gapdh glut1 h3k27 h4k5 interspecies iscnt klf4 lin28 nanog oct4 ooplasm ptger4 remodel scnt soon stella usf2 utp
Tagcloud (Intersection) ?