FLII and CARM1

Number of citations of the paper that reports this interaction (PMID 14966289)
31

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FLII	CARM1
Gene Name		flightless I homolog (Drosophila)	coactivator-associated arginine methyltransferase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Organizing Center Focal Adhesion	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Actin Binding Protein Binding	Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity (H3-R17 Specific) Histone Methyltransferase Activity Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Lysine-acetylated Histone Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Muscle Contraction Multicellular Organismal Development Actin Cytoskeleton Organization Actin Filament Severing	Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Pathogenesis Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Protein Binding Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-R2 Methylation Histone H3-R17 Methylation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fat Cell Differentiation Response To CAMP Endochondral Bone Morphogenesis
Pathways			PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Chromatin organization REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis RMTs methylate histone arginines Regulation of cholesterol biosynthesis by SREBP (SREBF) Chromatin modifying enzymes Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ACTB ACTL6A CARM1 DLST ESR1 GRIP1 LRRFIP1 LRRFIP2 MYD88 OPTN PRMT1 TRAIP	33 interactors: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 ELAVL1 EP300 FLII FOS GRIP1 H3F3A H3F3B HIST1H3A MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PIAS1 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRC SRCAP TP53 UBE2I
Entrez ID		2314	10498
HPRD ID		02647	09158
Ensembl ID		ENSG00000177731	ENSG00000142453
Uniprot IDs		Q13045	Q86X55
PDB IDs			2Y1W 2Y1X 4IKP
Enriched GO Terms of Interacting Partners?		Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Modification Signal Transduction Chromatin Organization Peptidyl-arginine N-methylation Signaling Cell Communication Histone Arginine Methylation Intracellular Estrogen Receptor Signaling Pathway Peptidyl-arginine Methylation Response To Stimulus Chromosome Organization Chromatin Remodeling Cellular Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling ATP-dependent Chromatin Remodeling Histone H3-R17 Methylation Positive Regulation Of Type I Interferon Production Histone Modification Histone H3-R2 Methylation Cell Development Regulation Of Type I Interferon Production Prostate Epithelial Cord Elongation L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Histone Methylation Response To Molecule Of Fungal Origin Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Negative Regulation Of Receptor Recycling Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Organelle Organization Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Interleukin-23 Production Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of RNA Metabolic Process Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Protein Methylation Regulation Of Growth Regulation Of Cellular Process Defense Response Golgi Ribbon Formation Establishment Of Endothelial Intestinal Barrier Regulation Of Organ Morphogenesis Defense Response To Bacterium	Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Chromatin Organization Transcription, DNA-templated Histone Acetylation RNA Biosynthetic Process Nitrogen Compound Metabolic Process Internal Peptidyl-lysine Acetylation Intracellular Receptor Signaling Pathway Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Internal Protein Amino Acid Acetylation RNA Metabolic Process Protein Acetylation Intracellular Steroid Hormone Receptor Signaling Pathway Organelle Organization Androgen Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process DNA Methylation On Cytosine Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Cellular Process Chromosome Organization Transcription From RNA Polymerase II Promoter Muscle Structure Development DNA Methylation
Tagcloud ?		a549 accessibility assisted brahma brg1 carm1 chromatin coactivator col1a2 depleted depletion drosophila enhancer faire flightless formaldehyde grip1 homolog isolation notably qpcr recruiting remodeling smad snf swi synergistic tgfbeta transforming	additionally arginine biological blocked candidates cardiovascular cofactor compound cyanine docking effectively guide methyltransferase micromolar occupying optimization pentamethine permeated prmt1 prmt5 prmt8 probes provided roadmap selectivity serve systematically transduction trimethine
Tagcloud (Difference) ?		a549 accessibility assisted brahma brg1 chromatin coactivator col1a2 depleted depletion drosophila enhancer faire flightless formaldehyde grip1 homolog isolation notably qpcr recruiting remodeling smad snf swi synergistic tgfbeta transforming	additionally arginine biological blocked candidates cardiovascular cofactor compound cyanine docking effectively guide methyltransferase micromolar occupying optimization pentamethine permeated prmt1 prmt5 prmt8 probes provided roadmap selectivity serve systematically transduction trimethine
Tagcloud (Intersection) ?		carm1