FOXM1 and CHEK2

Number of citations of the paper that reports this interaction (PMID 17101782)
51

Data Source:
BioGRID (enzymatic study)

		FOXM1	CHEK2
Gene Name		forkhead box M1	checkpoint kinase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus PML Body
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Regulation Of Cell Growth Vasculogenesis Liver Development DNA Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Positive Regulation Of Cell Proliferation Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ras Protein Signal Transduction Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Aging Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Double-strand Break Repair	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence
Pathways		Cyclin A/B1 associated events during G2/M transition G2/M Transition Mitotic G2-G2/M phases Cell Cycle, Mitotic Polo-like kinase mediated events
Drugs
Diseases
GWAS			Breast cancer ( 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		13 interactors: BANP CCNE1 CDK1 CDK2 CDK4 CDK6 CHEK2 CREBBP OS9 STAT3 SUMO1 UBE2I ZBTB3	47 interactors: AATF APP ARHGAP1 ASF1A ATM ATR BRCA1 BRCA2 CDC25A CDC25C DAPK3 DBF4 E2F1 ELAVL1 ERCC6 FOXM1 KPNA2 LATS2 MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 PLK1 PLK3 POLR2L PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RAD9A RCHY1 REV3L RNF8 SRPK1 STRAP TP53 TSSK1B VHL
Entrez ID		2305	11200
HPRD ID		03823	05084
Ensembl ID		ENSG00000111206	ENSG00000183765
Uniprot IDs		A8K591 Q08050 Q53Y49	O96017
PDB IDs		3G73	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?		Cell Division Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Gene Expression Cell Cycle Positive Regulation Of Gene Expression Cellular Protein Modification Process Cell Cycle Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Protein Localization To Organelle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Mitotic DNA Damage Checkpoint Phosphorylation Mitotic Nuclear Division Mitotic DNA Integrity Checkpoint Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Protein Phosphorylation G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Organelle Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Damage Checkpoint Cellular Response To Stress Mitotic Cell Cycle Checkpoint Protein Sumoylation Protein Localization To Nucleus	Cellular Response To DNA Damage Stimulus Cell Cycle Process Cellular Response To Stress Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Process DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Checkpoint Response To Stress Signal Transduction By P53 Class Mediator DNA Repair Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Response To Stimulus Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Negative Regulation Of Cell Cycle Apoptotic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Programmed Cell Death Mitotic DNA Damage Checkpoint Regulation Of Protein Metabolic Process Double-strand Break Repair Mitotic DNA Integrity Checkpoint Cell Death Death Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Response To Abiotic Stimulus Signal Transduction DNA Recombination Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Signaling Nucleobase-containing Compound Metabolic Process Cell Communication Double-strand Break Repair Via Homologous Recombination Recombinational Repair
Tagcloud ?		axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 gbm glioblastoma gsc gscs inversely irradiation melk mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 gbm glioblastoma gsc gscs inversely irradiation melk mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?