FGD1 and AOC1

Number of citations of the paper that reports this interaction (PMID 12913069)
25

Data Source:
HPRD (in vitro, in vivo)

		FGD1	AOC1
Gene Name		FYVE, RhoGEF and PH domain containing 1	amine oxidase, copper containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium	Extracellular Space Peroxisome Plasma Membrane Tight Junction Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding	Receptor Activity Cation Channel Activity Sodium Channel Activity Copper Ion Binding Calcium Ion Binding Primary Amine Oxidase Activity Drug Binding Heparin Binding Zinc Ion Binding Protein Complex Binding Protein Homodimerization Activity Quinone Binding Diamine Oxidase Activity Histamine Oxidase Activity Methylputrescine Oxidase Activity Propane-1,3-diamine Oxidase Activity
	Biological Process	Cytoskeleton Organization Signal Transduction Small GTPase Mediated Signal Transduction Multicellular Organismal Development Regulation Of Cell Shape Organ Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Cdc42 GTPase Activity Positive Regulation Of GTPase Activity Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Amine Metabolic Process Sodium Ion Transmembrane Transport Cellular Response To Copper Ion Starvation Response To Drug Response To Antibiotic Oxidation-reduction Process Cellular Response To Copper Ion Cellular Response To Histamine Cellular Response To Heparin Cellular Response To Azide
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs			Amiloride Diminazene
Diseases
GWAS
Protein-Protein Interactions		4 interactors: AOC1 CDC42 CTTN ELMO1	3 interactors: DAO DNM2 FGD1
Entrez ID		2245	26
HPRD ID		02373	00088
Ensembl ID		ENSG00000102302	ENSG00000002726
Uniprot IDs		P98174	C9J690 P19801
PDB IDs			3HI7 3HIG 3HII 3K5T 3MPH
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Adherens Junction Organization Endocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Copper Ion Starvation Cellular Response To Azide Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Hair Follicle Cell Proliferation Cytoskeleton Organization Cell-cell Junction Organization Actin Filament Branching Submandibular Salivary Gland Formation Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Phagocytosis Fc Receptor Signaling Pathway Cellular Response To Heparin Immune Response-activating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Cell Projection Assembly Response To Heparin Establishment Of Golgi Localization Cellular Response To Copper Ion Actin Filament Organization Movement Of Cell Or Subcellular Component Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Metalloenzyme Activity Regulation Of Protein Complex Assembly Dendritic Spine Maintenance Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Histamine Regulation Of Protein Heterodimerization Activity Keratinocyte Development Substrate-dependent Cell Migration, Cell Extension Regulation Of Synapse Structural Plasticity Response To Histamine Transport Positive Regulation Of Pseudopodium Assembly Nuclear Migration Cardiac Conduction System Development Phagocytosis, Engulfment Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Golgi Localization Regulation Of Cell Projection Organization	D-serine Catabolic Process D-alanine Catabolic Process Negative Regulation Of Membrane Tubulation D-amino Acid Catabolic Process D-serine Metabolic Process Glyoxylate Metabolic Process Leucine Metabolic Process Proline Catabolic Process Regulation Of Cell Morphogenesis Dopamine Biosynthetic Process Positive Regulation Of Apoptotic Process Serine Family Amino Acid Catabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Filopodium Assembly Catecholamine Biosynthetic Process Regulation Of Cdc42 GTPase Activity Nitric Oxide Metabolic Process Dopamine Metabolic Process Proline Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of Cdc42 Protein Signal Transduction Transferrin Transport Regulation Of Nitric-oxide Synthase Activity Catecholamine Metabolic Process Receptor Internalization Cell Projection Organization Serine Family Amino Acid Metabolic Process Regulation Of Axon Extension Cellular Aldehyde Metabolic Process Regulation Of Oxidoreductase Activity Iron Ion Transport Receptor Metabolic Process Regulation Of Apoptotic Process Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Cell Death Phenol-containing Compound Metabolic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Synaptic Vesicle Transport Reactive Oxygen Species Metabolic Process
Tagcloud ?		apo bend butterfly catalysis charged citrate coenzyme competitive crystallography facilitates flavin g6p helps identifies isoalloxazine microorganisms moiety mycobacteria nitroimidazopyran occupies packs persistence phosphate pocket prodrug replicating resolutions shared	adipocytes amine aoc2 aoc3 aos benzylamine diamine glycerol histamine histaminergic ileum invalidation ko lipolysis lipolytic mao maoa maob oxidases oxidation oxidized peroxide reaching rodent semicarbazide ssao visceral
Tagcloud (Difference) ?		apo bend butterfly catalysis charged citrate coenzyme competitive crystallography facilitates flavin g6p helps identifies isoalloxazine microorganisms moiety mycobacteria nitroimidazopyran occupies packs persistence phosphate pocket prodrug replicating resolutions shared	adipocytes amine aoc2 aoc3 aos benzylamine diamine glycerol histamine histaminergic ileum invalidation ko lipolysis lipolytic mao maoa maob oxidases oxidation oxidized peroxide reaching rodent semicarbazide ssao visceral
Tagcloud (Intersection) ?