FBLN2 and BCAN

Number of citations of the paper that reports this interaction (PMID 11038354)
38

Data Source:
HPRD (in vitro)

		FBLN2	BCAN
Gene Name		fibulin 2	brevican
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix Vesicle Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Anchored Component Of Membrane Lysosomal Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization	Skeletal System Development Carbohydrate Metabolic Process Cell Adhesion Central Nervous System Development Pathogenesis Hippocampus Development Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process
Pathways		Molecules associated with elastic fibres Elastic fibre formation	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		22 interactors: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ELN FBN1 FN1 HSPG2 ITGB3 LAMA1 LAMA5 LAMC2 NID1 PRELP VCAN ZNF408	10 interactors: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR
Entrez ID		2199	63827
HPRD ID		00630	02644
Ensembl ID		ENSG00000163520	ENSG00000132692
Uniprot IDs		F5H1F3 P98095 Q86V58 Q9Y3V7	Q96GW7
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development System Development Developmental Process Multicellular Organismal Development Cell Adhesion Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Catabolic Process Cardiovascular System Development Blood Vessel Morphogenesis Locomotion Catabolic Process Blood Vessel Development Cell Morphogenesis Nervous System Development Angiogenesis Vasculature Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Axon Guidance Tissue Development Cell-substrate Junction Assembly Cell Development Organ Development Axonogenesis Glomerular Basement Membrane Development Renal System Development Cell Projection Morphogenesis Glycosaminoglycan Metabolic Process Axon Development Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Urogenital System Development Pathogenesis Neuron Projection Morphogenesis Cell Differentiation Proteoglycan Metabolic Process Cell Projection Organization Neuron Projection Development Retinal Blood Vessel Morphogenesis Kidney Development Neurogenesis	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Endodermal Cell Differentiation Endoderm Formation Protein Metabolic Process Cellular Response To Amino Acid Stimulus Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Axon Extension Involved In Regeneration Endoderm Development Response To Amino Acid Formation Of Primary Germ Layer Skeletal System Development Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Gastrulation Defense Response To Bacterium Positive Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Axon Regeneration Positive Regulation Of Oxidative Stress-induced Cell Death Intramembranous Ossification Regulation Of Hydrogen Peroxide Metabolic Process Bone Trabecula Formation Response To External Stimulus Regulation Of Transmission Of Nerve Impulse Locomotory Exploration Behavior Blood Vessel Maturation Skeletal System Morphogenesis Cellular Response To Nitric Oxide Ossification Neuron Cell-cell Adhesion Response To Nitric Oxide Positive Regulation Of Cellular Component Biogenesis Bone Trabecula Morphogenesis Regulation Of Axon Regeneration Regulation Of Protein Complex Assembly Growth Plate Cartilage Development Response To Stress Positive Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Reactive Nitrogen Species
Tagcloud ?		3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing	abundant astrocytes basic cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt
Tagcloud (Difference) ?		3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing	abundant astrocytes basic cg clustering differentiated diverse embryos enriched forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt
Tagcloud (Intersection) ?		fbln2