FANCA and NAMPT

Number of citations of the paper that reports this interaction (PMID 14499622)
5

Data Source:
BioGRID (two hybrid)

		FANCA	NAMPT
Gene Name		Fanconi anemia, complementation group A	nicotinamide phosphoribosyltransferase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Fanconi Anaemia Nuclear Complex	Extracellular Space Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Drug Binding Protein Homodimerization Activity Nicotinamide Phosphoribosyltransferase Activity
	Biological Process	DNA Repair Protein Complex Assembly Male Meiosis Male Gonad Development Female Gonad Development Regulation Of Cell Proliferation	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Signal Transduction Cell-cell Signaling Female Pregnancy Circadian Rhythm Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway NAD Biosynthetic Process Response To Organic Cyclic Compound NAD Metabolic Process Circadian Regulation Of Gene Expression Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development
Pathways		Fanconi Anemia pathway	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Nicotinamide salvaging Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinate metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		46 interactors: AKT1 ALDOA ATP5B ATR AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 HSP90AA1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24	4 interactors: ADORA2A AKT2 FANCA GGT1
Entrez ID		2175	10135
HPRD ID		06186	09938
Ensembl ID		ENSG00000187741	ENSG00000105835
Uniprot IDs		H3BSR5 O15360 Q86U55	P43490
PDB IDs			2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4M6P 4M6Q
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Complex Assembly Cellular Response To Stress Peptidyl-serine Phosphorylation Metabolic Process Nucleosome Disassembly Response To Stimulus Immune System Process Positive Regulation Of Cellular Metabolic Process Cellular Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Heat Cellular Component Assembly Response To Heat Regulation Of Cellular Process Apoptotic Process Cell Cycle Checkpoint Regulation Of Protein Catabolic Process Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus DNA Repair Cell Cycle Process Innate Immune Response Response To Virus Cell Death Death Reproductive Process Positive Regulation Of Cellular Biosynthetic Process 'de Novo' Posttranslational Protein Folding Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Nucleosome Organization 'de Novo' Protein Folding Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Chromatin Assembly Or Disassembly DNA Damage Checkpoint Cellular Response To Heat Regulation Of Metabolic Process Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Apoptotic Process	Glutathione Catabolic Process Activation Of Ral GTPase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Cysteine Biosynthetic Process Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Cysteine Metabolic Process Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Beta-oxidation Adenosine Receptor Signaling Pathway Positive Regulation Of Vesicle Fusion Peptide Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process CAMP Biosynthetic Process Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Lipid Transport Myelin Maintenance Leukotriene Biosynthetic Process Glutathione Biosynthetic Process Glutathione Derivative Biosynthetic Process Glutamate Metabolic Process Positive Regulation Of Lipid Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycogen Biosynthetic Process Regulation Of Vesicle Fusion Activation Of Adenylate Cyclase Activity Peptide Biosynthetic Process Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Transport Leukotriene Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Glucose Import Cellular Response To Stimulus Myelination In Peripheral Nervous System CAMP Metabolic Process Regulation Of Glycogen Metabolic Process Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Glucose Transport
Tagcloud ?		aml anemia aplastic autosomal brca2 collaborate complicated cumulative cure decision fancd1 fanconi fancq genotypes gynecologic head inherited neck preemptive prone recessive risks solid squamous subset transplant usually wilms	atp attribute autophagy concurrent connect deacetylases deacetylate depleted depletion driven fail gne illustrates inability k40 k9 limiting lose metabolite motility nad oncology oncosis predominant regenerate reveals slower tubulin utilize
Tagcloud (Difference) ?		aml anemia aplastic autosomal brca2 collaborate complicated cumulative cure decision fancd1 fanconi fancq genotypes gynecologic head inherited neck preemptive prone recessive risks solid squamous subset transplant usually wilms	atp attribute autophagy concurrent connect deacetylases deacetylate depleted depletion driven fail gne illustrates inability k40 k9 limiting lose metabolite motility nad oncology oncosis predominant regenerate reveals slower tubulin utilize
Tagcloud (Intersection) ?