HIPK1 and PARK7

Number of citations of the paper that reports this interaction (PMID 16390825)
11

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)

		HIPK1	PARK7
Gene Name		homeodomain interacting protein kinase 1	parkinson protein 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body Nuclear Speck	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Plasma Membrane PML Body Axon Cell Body Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Core Promoter Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity MRNA Binding Receptor Binding Copper Ion Binding Protein Binding Transcription Factor Binding Peptidase Activity Superoxide Dismutase Copper Chaperone Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Glyoxalase III Activity Enzyme Binding Kinase Binding Cytokine Binding Tyrosine 3-monooxygenase Activator Activity L-dopa Decarboxylase Activator Activity Identical Protein Binding Protein Homodimerization Activity Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Mercury Ion Binding Androgen Receptor Binding Peroxiredoxin Activity Repressing Transcription Factor Binding Scaffold Protein Binding Cupric Ion Binding Cuprous Ion Binding Ubiquitin-specific Protease Binding Glyoxalase (glycolic Acid-forming) Activity
	Biological Process	Eye Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Smoothened Signaling Pathway Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Retina Layer Formation Neuron Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Angiogenesis Embryonic Camera-type Eye Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Definitive Hemopoiesis Lens Induction In Camera-type Eye Iris Morphogenesis Endothelial Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Proteolysis Protein Deglycosylation Autophagy Inflammatory Response Mitochondrion Organization Ras Protein Signal Transduction Single Fertilization Adult Locomotory Behavior Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Enzyme Active Site Formation Via L-cysteine Sulfinic Acid Methylglyoxal Catabolic Process To D-lactate Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Cellular Response To Glyoxal Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of TRAIL Receptor Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Glycolate Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Regulation Of Inflammatory Response Detoxification Of Mercury Ion Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Dopamine Uptake Involved In Synaptic Transmission Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Membrane Depolarization Membrane Hyperpolarization Negative Regulation Of Cell Death Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Positive Regulation Of Superoxide Dismutase Activity Negative Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Fibril Organization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Dopamine Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of L-dopa Biosynthetic Process Positive Regulation Of L-dopa Decarboxylase Activity Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Androgen Receptor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs			Double Oxidized Cysteine
Diseases
GWAS		Breast cancer ( 23535729)	Celiac disease ( 20190752) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		13 interactors: ATP13A2 DAXX FHL3 GLUL HOXD4 NKX2-5 PARK7 PRPF40A RUNX1 SKIL SNIP1 TP53 UBE2I	20 interactors: BAX BBS1 BCL2L1 CASP8 CSN1S1 DAXX EFCAB6 FADD GOPC HIPK1 NDUFA4 PIAS2 PINK1 PPP2R1A PPP2R1B PTEN SOD1 SUMO1 UBA2 UBE2I
Entrez ID		204851	11315
HPRD ID		06418	03961
Ensembl ID		ENSG00000163349	ENSG00000116288
Uniprot IDs		B4DZ33 Q86Z02	K7ELW0 Q99497
PDB IDs			1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Neurotransmitter Uptake Positive Regulation Of Transport Regulation Of Signaling Regulation Of Transcription, DNA-templated Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Toxic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Gene Expression Response To Transforming Growth Factor Beta Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Muscle Cell Apoptotic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Muscle Organ Development Positive Regulation Of Transporter Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Death Cell Proliferation Negative Regulation Of Biosynthetic Process Cell Cycle Response To Antibiotic Negative Regulation Of Cell Differentiation Nitrogen Compound Metabolic Process Organelle Organization Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Atrioventricular Node Cell Fate Commitment Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway	Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Sumoylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Potential Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cell Death Regulation Of Lymphocyte Apoptotic Process Apoptotic Signaling Pathway Regulation Of Catalytic Activity Regulation Of Mitochondrion Organization Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process TRAIL-activated Apoptotic Signaling Pathway Regulation Of Membrane Potential Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Neuron Death Positive Regulation Of Protein Metabolic Process Membrane Organization Viral Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Peptidase Activity Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Death Regulation Of Metabolic Process Organelle Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Cellular Protein Metabolic Process Neuron Apoptotic Process Response To Toxic Substance Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization
Tagcloud ?		1gamma chromo ddr dead doi flag gammah2a h3k9me3 hct116 hipk2 homeodomain hp1 hp1alpha hp1beta hp1box hp1gamma lys9 onc phosphorylating ptvsv ser139 shadow silenced sublethal tagged trimethylated ultraviolet uncover uv	account alleviates antioxidant clear completely conversely deficiency dj effectively elusive exerts familial hypersensitivity hypersensitizes importantly interacting interestingly neurons oxidative paradigm paraoxonase parkinson partly pd phenylpyridinium pon2 protects rescues stress
Tagcloud (Difference) ?		1gamma chromo ddr dead doi flag gammah2a h3k9me3 hct116 hipk2 homeodomain hp1 hp1alpha hp1beta hp1box hp1gamma lys9 onc phosphorylating ptvsv ser139 shadow silenced sublethal tagged trimethylated ultraviolet uncover uv	account alleviates antioxidant clear completely conversely deficiency dj effectively elusive exerts familial hypersensitivity hypersensitizes importantly interacting interestingly neurons oxidative paradigm paraoxonase parkinson partly pd phenylpyridinium pon2 protects rescues stress
Tagcloud (Intersection) ?