EPB41L2 and NUMA1

Number of citations of the paper that reports this interaction (PMID 12239178)
4

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		EPB41L2	NUMA1
Gene Name		erythrocyte membrane protein band 4.1-like 2	nuclear mitotic apparatus protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Focal Adhesion Spectrin COP9 Signalosome Extrinsic Component Of Membrane Cell Junction Extracellular Vesicular Exosome	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Spindle Microtubule Nuclear Matrix Dendrite Neuronal Cell Body Apical Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Structural Molecule Activity PH Domain Binding	Structural Molecule Activity Protein Binding Microtubule Binding
	Biological Process	Cortical Actin Cytoskeleton Organization	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleus Organization Mitotic Nuclear Division Cell Division Meiotic Cell Cycle Lung Epithelial Cell Differentiation
Pathways			G2/M Transition Centrosome maturation Mitotic G2-G2/M phases Recruitment of NuMA to mitotic centrosomes Cell Cycle, Mitotic Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS		Lentiform nucleus volume ( 22903471) Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		13 interactors: ACTA1 ADORA1 APP ATXN1L DRD1 DRD3 FKBP2 GRIA1 NUMA1 SPTAN1 YWHAG YWHAH YWHAZ	22 interactors: ACTR1A BRAP CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 SMC1A TERF1 TERF2 TERF2IP TNKS YEATS4 YWHAQ
Entrez ID		2037	4926
HPRD ID		09126	01236
Ensembl ID		ENSG00000079819	ENSG00000137497
Uniprot IDs		B4DJ76 E9PHY5 E9PII3 I6L9B1 O43491 O60642 Q59FD8	Q14980 Q3SYK8 Q4LE64
PDB IDs			3RO2
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cognition Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Mitochondrion Organization System Development Visual Learning Negative Regulation Of Synaptic Transmission Visual Behavior Neuron-neuron Synaptic Transmission Apoptotic Process Positive Regulation Of Intracellular Transport Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Learning Or Memory Regulation Of Dopamine Uptake Involved In Synaptic Transmission Associative Learning Multicellular Organismal Development Regulation Of Mitochondrion Organization Anatomical Structure Development Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Apoptotic Signaling Pathway Regulation Of Neurotransmitter Uptake Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Establishment Of Localization In Cell Prepulse Inhibition Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Long Term Synaptic Depression Regulation Of Synaptic Transmission, Dopaminergic Neuromuscular Process Positive Regulation Of Organelle Organization Learning Regulation Of Signaling Regulation Of Anion Transport Protein Targeting Developmental Process Regulation Of Renal Sodium Excretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Intracellular Transport Nervous System Development Intracellular Transport Cell-cell Signaling Regulation Of Excretion	Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Regulation Of Telomere Maintenance Cell Cycle Process Protein Localization To Chromosome, Telomeric Region Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cortical Actin Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication RNA-dependent DNA Replication Cortical Cytoskeleton Organization Cell Division Negative Regulation Of DNA Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Mitotic Nuclear Division Telomere Capping Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Regulation Of Cell Cycle DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cytoskeleton Organization Positive Regulation Of Organelle Organization Negative Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Mitotic Spindle Organization Regulation Of Metabolic Process Protein Localization To Organelle Regulation Of Organelle Organization Cell Dedifferentiation Negative Regulation Of Potassium Ion Export Negative Regulation Of DNA Recombination At Telomere Cellular Response To Stimulus
Tagcloud ?			6448dup brca1 brca2 ccnd1 cox11 discovery fgfr2 focused great history importance malignancy manage members moderate modifiers modify polygenic polymorphisms predictor search slc4a7 strongest tnrc9 today transmission variant variants whose
Tagcloud (Difference) ?			6448dup brca1 brca2 ccnd1 cox11 discovery fgfr2 focused great history importance malignancy manage members moderate modifiers modify polygenic polymorphisms predictor search slc4a7 strongest tnrc9 today transmission variant variants whose
Tagcloud (Intersection) ?