TUBB and MAP6

Number of citations of the paper that reports this interaction (PMID 8700896)
13

Data Source:
HPRD (in vitro, in vivo)

		TUBB	MAP6
Gene Name		tubulin, beta class I	microtubule-associated protein 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Cytosol Cytoskeleton Microtubule Cytoplasmic Ribonucleoprotein Granule Cell Body Extracellular Vesicular Exosome	Golgi Apparatus Microtubule Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Complex Binding GTPase Activating Protein Binding MHC Class I Protein Binding	Protein Binding Calmodulin Binding Microtubule Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Organelle Organization Microtubule-based Process Cellular Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Spindle Assembly Protein Polymerization Cell Division	Microtubule Cytoskeleton Organization Transport Lysosome Localization Dendrite Morphogenesis
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Epothilone B
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CCT2 CDKN2A CLIP1 CMTM5 CNN1 CRIPT DISC1 DPYSL2 DYNLL1 ESR1 GDAP1 GNB2L1 GRM1 HDAC6 HGS HTRA2 HTT MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MX1 NCALD NCAM1 NPHP1 PARK2 PFDN4 PLK1 RAB8B RASSF1 SDC3 SIRT2 SPP1 STAU1 SYT9 TAOK2 TBCD TGM2 TINF2 TTBK1 TTK TUBA1A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	6 interactors: NR2F1 RARB RARG RORB TRAF1 TUBB
Entrez ID		203068	4135
HPRD ID		01852	15989
Ensembl ID		ENSG00000196230	ENSG00000171533
Uniprot IDs		B4DMJ5 P07437 Q5ST81 Q5SU16	Q6ZWB8 Q96JE9
PDB IDs		3QNZ 3QO0
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cytoskeleton Organization Microtubule Cytoskeleton Organization Positive Regulation Of Signal Transduction Cellular Localization Microtubule-based Process Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Programmed Cell Death Positive Regulation Of Organelle Organization Regulation Of Cell Death Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Process Cell Communication Cellular Protein Localization Regulation Of Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Signaling Regulation Of Apoptotic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Cycle Signal Transduction Cell Cycle Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Negative Regulation Of Protein Metabolic Process Mitotic Cell Cycle Nervous System Development Regulation Of Protein Localization	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Retinal Pigment Epithelium Development Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Eye Morphogenesis Retina Development In Camera-type Eye Growth Plate Cartilage Development Negative Regulation Of Cell Differentiation Negative Regulation Of Chondrocyte Differentiation Retinoic Acid Receptor Signaling Pathway Endochondral Bone Growth Glandular Epithelial Cell Development Response To Lipid Negative Regulation Of Cartilage Development Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Cartilage Development Involved In Endochondral Bone Morphogenesis Response To Hormone Embryonic Eye Morphogenesis Columnar/cuboidal Epithelial Cell Development Glandular Epithelial Cell Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Myelination Embryonic Hindlimb Morphogenesis Camera-type Eye Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Hindlimb Morphogenesis Eye Development Cellular Response To Retinoic Acid Regulation Of Chondrocyte Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Endochondral Bone Morphogenesis Regulation Of Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organ Growth Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Sensory Organ Development Multicellular Organism Growth
Tagcloud ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	al als amyotrophic become combine degeneration embo frontotemporal ftld genetically issue journal lateral live lobar lysosomal partner pathologies pathology played priority proteomics schwenk sclerosis tdp tmem106b uncovering unveil variants
Tagcloud (Difference) ?		3p ahi1 annotation clustering datasets demyelinating differential dqb1 dra eqtl eqtls grail highlighted hla loci ms ndfip1 publically relevance rs1062158 rs11154801 rs2647046 rs3095329 rs7194 rs9469220 snps tf trait utilizing	al als amyotrophic become combine degeneration embo frontotemporal ftld genetically issue journal lateral live lobar lysosomal partner pathologies pathology played priority proteomics schwenk sclerosis tdp tmem106b uncovering unveil variants
Tagcloud (Intersection) ?