A2M and NGF

Number of citations of the paper that reports this interaction (PMID 10681572)
9

Data Source:
HPRD (in vitro)

		A2M	NGF
Gene Name		alpha-2-macroglobulin	nerve growth factor (beta polypeptide)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Endosome Golgi Lumen Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Receptor Signaling Protein Activity Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	Activation Of MAPKK Activity Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Peripheral Nervous System Development Memory Circadian Rhythm Adult Locomotory Behavior Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Radiation Response To Mechanical Stimulus Response To Ozone Positive Regulation Of Gene Expression Positive Regulation Of Neuron Maturation Sensory Perception Of Pain Positive Regulation Of Protein Autophosphorylation Nerve Growth Factor Processing Response To Lipopolysaccharide Response To Nicotine Nerve Growth Factor Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Cell Cycle Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Glucocorticoid Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Response To Electrical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation	Retrograde neurotrophin signalling Signalling to ERKs Prolonged ERK activation events NF-kB is activated and signals survival p75NTR recruits signalling complexes Axonal growth stimulation Ceramide signalling PI3K/AKT activation p75NTR signals via NF-kB NGF processing NFG and proNGF binds to p75NTR Signalling to p38 via RIT and RIN Signalling by NGF p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Activation of TRKA receptors p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF NRIF signals cell death from the nucleus Signalling to RAS NRAGE signals death through JNK Signalling to STAT3 PLC-gamma1 signalling NADE modulates death signalling Frs2-mediated activation
Drugs		Becaplermin Bacitracin Ocriplasmin	Clenbuterol
Diseases
GWAS			Non-alcoholic fatty liver disease ( 23535911)
Protein-Protein Interactions		93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS	8 interactors: A2M CRYAB MMP7 NGFR NTRK1 PLG SORCS3 SORT1
Entrez ID		2	4803
HPRD ID		00072	08874
Ensembl ID		ENSG00000175899	ENSG00000134259
Uniprot IDs		P01023	P01138
PDB IDs		1BV8 2P9R 4ACQ	1SG1 1WWW 2IFG
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing	Extracellular Matrix Disassembly Nerve Growth Factor Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Detection Of Temperature Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Developmental Programmed Cell Death Cell Differentiation Extracellular Matrix Organization Programmed Cell Death Extracellular Structure Organization Response To Stimulus Regulation Of Endopeptidase Activity Cell Death Death Negative Regulation Of Hydrolase Activity Platelet Degranulation Regulation Of Peptidase Activity Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Neuropeptide Signaling Pathway Regulation Of Catalytic Activity Nerve Development Muscle Structure Development Negative Regulation Of Complement Activation, Lectin Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Proliferation Secretion Regulation Of Long Term Synaptic Depression Mononuclear Cell Migration Negative Regulation Of Hair Follicle Development Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Fibrinolysis Circadian Rhythm Detection Of Abiotic Stimulus Negative Regulation Of Catalytic Activity Response To Temperature Stimulus Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Cysteine-type Endopeptidase Activity Signal Transduction Axonogenesis Involved In Innervation
Tagcloud ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither	afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small
Tagcloud (Difference) ?		a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither	afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small
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