ELF1 and NFYA

Number of citations of the paper that reports this interaction (PMID 9668064)
13

Data Source:
BioGRID (pull down)

		ELF1	NFYA
Gene Name		E74-like factor 1 (ets domain transcription factor)	nuclear transcription factor Y, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Core Promoter Sequence-specific DNA Binding Transcription Cofactor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of Cytokine Production Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of T Cell Receptor Signaling Pathway	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Stem Cell Maintenance Positive Regulation Of Stem Cell Proliferation
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins ATF4 activates genes ATF6-alpha activates chaperone genes Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) PERK regulates gene expression ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Crohn's disease ( 23266558) Systemic lupus erythematosus ( 23273568 21044949)
Protein-Protein Interactions		8 interactors: HMGA1 HOXC13 NFKB1 NFYA NFYB RB1 REL SP1	37 interactors: APP APPBP2 ATF6 ATF6B BRCA1 CCNA2 CDC25A CDK2 CEBPA CSNK2A1 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 PWP1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TP53 USF1 USF2 ZHX1 ZHX2 ZHX3
Entrez ID		1997	4800
HPRD ID		01808	01793
Ensembl ID		ENSG00000120690
Uniprot IDs		P32519 Q6MZZ4	P23511
PDB IDs			4AWL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Enucleate Erythrocyte Differentiation Nitrogen Compound Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process NIK/NF-kappaB Signaling Regulation Of Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Regulation Of Interleukin-12 Production Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Sequestering Of Nodal From Receptor Via Nodal Binding Negative Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Gene Expression Erythrocyte Differentiation Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Biosynthetic Process Viral Process Erythrocyte Homeostasis Negative Regulation Of Nodal Signaling Pathway Oncogene-induced Cell Senescence Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Myeloid Cell Homeostasis Negative Regulation Of Calcidiol 1-monooxygenase Activity	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Viral Process Cellular Metabolic Process Positive Regulation Of Transcription By Glucose Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation By Host Of Viral Transcription Negative Regulation Of Nucleic Acid-templated Transcription Metabolic Process Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Late Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cellular Response To Nutrient Levels Regulation Of Cell Cycle
Tagcloud ?		133a bidirectional biphasic compatible concurrently datasets declining directionally e2f ets ets2 gabp hf insult interrelated kegg late microrna mirna miss myocyte nonfailing omnibus overlapping overrepresented repository rising transcripts undergo	anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nutshell oprk1 pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp usf usf2 vdr vulnerability
Tagcloud (Difference) ?		133a bidirectional biphasic compatible concurrently datasets declining directionally e2f ets ets2 gabp hf insult interrelated kegg late microrna mirna miss myocyte nonfailing omnibus overlapping overrepresented repository rising transcripts undergo	anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nutshell oprk1 pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp usf usf2 vdr vulnerability
Tagcloud (Intersection) ?