PHC2 and MAPK14

Number of citations of the paper that reports this interaction (PMID 21675959)
3

Data Source:
BioGRID (protein complementation assay)

		PHC2	MAPK14
Gene Name		polyhomeotic homolog 2 (Drosophila)	mitogen-activated protein kinase 14
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Spindle Pole Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding NFAT Protein Binding
	Biological Process	Multicellular Organismal Development Spermatogenesis	DNA Damage Checkpoint Activation Of MAPK Activity Cell Morphogenesis Cartilage Condensation Angiogenesis Chondrocyte Differentiation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Movement Of Cell Or Subcellular Component Chemotaxis Organelle Organization Mitochondrion Organization Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ras Protein Signal Transduction Skeletal Muscle Tissue Development Blood Coagulation Gene Expression Positive Regulation Of Myotube Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Peptidyl-serine Phosphorylation Fatty Acid Oxidation Platelet Activation Osteoclast Differentiation Lipopolysaccharide-mediated Signaling Pathway Response To Muramyl Dipeptide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Muscle Cell Differentiation Signal Transduction In Response To DNA Damage Positive Regulation Of Blood Vessel Endothelial Cell Migration Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Brown Fat Cell Differentiation Stress-induced Premature Senescence Positive Regulation Of Myoblast Fusion Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	ADP signalling through P2Y purinoceptor 1 Cellular Senescence Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p38MAPK events MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Myogenesis Signaling by VEGF Platelet sensitization by LDL Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation Signalling to ERKs Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade Signal amplification VEGFA-VEGFR2 Pathway Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Mitochondrial biogenesis Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade DSCAM interactions KSRP destabilizes mRNA Oxidative Stress Induced Senescence Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs			4-[5-[2-(1-Phenyl-Ethylamino)-Pyrimidin-4-Yl]-1-Methyl-4-(3-Trifluoromethylphenyl)-1h-Imidazol-2-Yl]-Piperidine N-[(3z)-5-Tert-Butyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol-3-Ylidene]-N\'-(4-Chlorophenyl)Urea 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One Inhibitor of P38 Kinase 6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine 3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine 1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea 3-(Benzyloxy)Pyridin-2-Amine 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One 4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline 1-(5-Tert-Butyl-2-P-Tolyl-2h-Pyrazol-3-Yl)-3-[4-(2-Morpholin-4-Yl-Ethoxy)-Naphthalen-1-Yl]-Urea 2-Chlorophenol 4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole SB220025 4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE Triazolopyridine 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE N-cyclopropyl-2\',6-dimethyl-4\'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE 4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde N-(3-cyanophenyl)-2\'-methyl-5\'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide N-(cyclopropylmethyl)-2\'-methyl-5\'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide N~3~-cyclopropyl-N~4~\'-(cyclopropylmethyl)-6-methylbiphenyl-3,4\'-dicarboxamide 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl}-N,4-dimethylbenzamide 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine 2-{4-[5-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-3-yl]piperidin-1-yl}-2-oxoethanol N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N\'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO- 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE 3-FLUORO-N-1H-INDOL-5-YL-5-MORPHOLIN-4-YLBENZAMIDE 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE 3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE
Diseases
GWAS
Protein-Protein Interactions		68 interactors: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CBX8 CRKL CSNK2B DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 GFI1B GRB2 HIST3H3 KAT5 KBTBD7 KDM1A KIFC3 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MORF4L2 NCK1 PCGF2 PCGF3 PCGF5 PHC1 PLK1 POLR2L PPP1R16B PRKAA1 PRPF31 RBM39 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 ZBTB24 ZGPAT ZMAT2 ZNF417	142 interactors: AES AIMP1 AKT1 ATF2 BAZ1B BCL2 BICD1 BMI1 CCDC14 CCDC97 CD4 CDC25A CDC25B CDC25C CDX2 CENPC CEP164 COPS5 CREB1 CSNK2A1 CSNK2A2 CSNK2B DDIT3 DDX26B DUSP1 DUSP10 DUSP16 DUSP2 DUSP22 DUSP4 DUSP7 DUSP9 DYRK1B EEA1 EEF1A1 EEF2K EGFR EIF4EBP1 ELK1 ELK3 ELMSAN1 EPB42 ESR1 ETV1 FKBP8 FLNA FUBP1 GADD45A GDF15 GMFB GORASP2 GRB2 HDAC3 HIVEP1 HNF4A HSF4 HTRA2 IRAK1 JDP2 JUN JUNB KARS KAT2B KMT2C KRT18 KRT8 LIMK1 MAFA MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K10 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARS MAX MBP MEF2A MEF2C MEF2D MITF MKNK1 MKNK2 MOB3B MUC12 NCOA3 NFATC1 NFATC4 NKTR NUP153 PAK6 PHC2 PI4K2B PLA2G4A PLG PML PPARGC1A PTPN7 RBSN RELA RET ROBO1 RPL22 RPL41 RPS6KA4 RPS6KA5 SCN8A SH2D1A SHC1 SLC9A1 SMAD3 SMAD7 SMARCD3 SMEK1 SNAPIN SPAG9 SPTBN1 SQSTM1 SRPK1 SRSF5 STAT1 STAT4 STK39 SUPT20H TAB1 TCF20 TFCP2 TMEM63B TP53 TRAF6 UGT2B10 YY1AP1 ZFP36L1 ZNF142 ZNHIT1
Entrez ID		1912	1432
HPRD ID		10340	02619
Ensembl ID		ENSG00000134686	ENSG00000112062
Uniprot IDs		B3KPJ4 Q8IXK0	L7RSM2 Q16539
PDB IDs			1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2FSL 2FSM 2FSO 2FST 2GFS 2I0H 2LGC 2NPQ 2OKR 2ONL 2QD9 2RG5 2RG6 2Y8O 2YIS 2YIW 2YIX 2ZAZ 2ZB0 2ZB1 3BV2 3BV3 3BX5 3C5U 3CTQ 3D7Z 3D83 3DS6 3DT1 3E92 3E93 3FC1 3FI4 3FKL 3FKN 3FKO 3FL4 3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK 3FML 3FMM 3FMN 3FSF 3FSK 3GC7 3GCP 3GCQ 3GCS 3GCU 3GCV 3GFE 3GI3 3HA8 3HEC 3HEG 3HL7 3HLL 3HP2 3HP5 3HRB 3HUB 3HUC 3HV3 3HV4 3HV5 3HV6 3HV7 3HVC 3IPH 3ITZ 3IW5 3IW6 3IW7 3IW8 3K3I 3K3J 3KF7 3KQ7 3L8S 3L8X 3LFA 3LFB 3LFC 3LFD 3LFE 3LFF 3LHJ 3MGY 3MH0 3MH1 3MH2 3MH3 3MPA 3MPT 3MVL 3MVM 3MW1 3NEW 3NNU 3NNV 3NNW 3NNX 3NWW 3O8P 3O8T 3O8U 3OBG 3OBJ 3OC1 3OCG 3OD6 3ODY 3ODZ 3OEF 3PG3 3QUD 3QUE 3RIN 3ROC 3S3I 3S4Q 3U8W 3UVP 3UVQ 3UVR 3ZS5 3ZSG 3ZSH 3ZSI 3ZYA 4A9Y 4AA0 4AA4 4AA5 4AAC 4DLI 4DLJ 4E5A 4E5B 4E6A 4E6C 4E8A 4EH2 4EH3 4EH4 4EH5 4EH6 4EH7 4EH8 4EH9 4EHV 4EWQ 4F9W 4F9Y 4FA2 4GEO 4KIN 4KIP 4KIQ
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Gene Expression Chromatin Organization Chromosome Organization Chromatin Modification Organelle Organization Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Phosphorus Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Phosphorylation Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Histone Modification Cellular Response To DNA Damage Stimulus Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Developmental Process Positive Regulation Of Signal Transduction Immune System Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Regulation Of Signal Transduction Anatomical Structure Development Response To Ionizing Radiation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Immune System Development Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 4 Signaling Pathway MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Toll-like Receptor Signaling Pathway Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Metabolic Process Cellular Response To Organic Substance Cellular Metabolic Process Regulation Of Phosphorylation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process Cellular Response To Growth Factor Stimulus Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Response To Growth Factor Signaling Positive Regulation Of Cellular Biosynthetic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Transcription, DNA-templated Phosphorylation Regulation Of MAP Kinase Activity Response To Stress Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Anatomical Structure Development Phosphate-containing Compound Metabolic Process
Tagcloud ?		ansa arene bent binuclear bp86 c6 cf3 chelate concurred conversions coordinative diphenylethane ga gaga gallium h5 hexamethylbenzene me2 me3 me6 mesitylene multinuclear olefinic ph2 polyisobutylene reactivities terphenyl univalent xylene	acta2 cdh1 cdkn1a cldn1 cldn4 cldn7 ctnnb1 fn1 krt19 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim
Tagcloud (Difference) ?		ansa arene bent binuclear bp86 c6 cf3 chelate concurred conversions coordinative diphenylethane ga gaga gallium h5 hexamethylbenzene me2 me3 me6 mesitylene multinuclear olefinic ph2 polyisobutylene reactivities terphenyl univalent xylene	acta2 cdh1 cdkn1a cldn1 cldn4 cldn7 ctnnb1 fn1 krt19 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim
Tagcloud (Intersection) ?