AGT and AGTR2

Number of citations of the paper that reports this interaction (PMID 8185599)
6

Data Source:
HPRD (in vivo)

		AGT	AGTR2
Gene Name		angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	angiotensin II receptor, type 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Hormone Activity Protein Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Type 1 Angiotensin Receptor Binding Type 2 Angiotensin Receptor Binding	Angiotensin Type II Receptor Activity Protein Binding Transcription Factor Binding Peptide Hormone Binding Receptor Antagonist Activity
	Biological Process	Ovarian Follicle Rupture Regulation Of Cell Growth Blood Vessel Development Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cytokine Production Kidney Development Blood Vessel Remodeling Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Renal Output By Angiotensin Regulation Of Blood Vessel Size By Renin-angiotensin Renal System Process Angiotensin-mediated Drinking Behavior Positive Regulation Of Extracellular Matrix Constituent Secretion Cellular Sodium Ion Homeostasis Cell-matrix Adhesion G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Activation Of NF-kappaB-inducing Kinase Activity Nitric Oxide Mediated Signal Transduction Cell-cell Signaling Female Pregnancy Aging Excretion Establishment Of Blood-nerve Barrier Negative Regulation Of Cell Proliferation Response To Cold Response To Salt Stress Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Negative Regulation Of Endopeptidase Activity Regulation Of Norepinephrine Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Negative Regulation Of Angiogenesis Regulation Of Vasoconstriction Extracellular Matrix Organization Negative Regulation Of Cell Growth Peristalsis Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Tissue Remodeling Low-density Lipoprotein Particle Remodeling Catenin Import Into Nucleus Regulation Of Renal Sodium Excretion Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Vasodilation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Metabolic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Positive Regulation Of Organ Growth Astrocyte Activation Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Smooth Muscle Cell Proliferation Cytokine Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Smooth Muscle Cell Differentiation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Regulation Of Calcium Ion Transport Regulation Of Transmission Of Nerve Impulse Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Protein Tyrosine Kinase Activity ERK1 And ERK2 Cascade Uterine Smooth Muscle Contraction Cellular Response To Mechanical Stimulus Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure Brain Renin-angiotensin System Cellular Sodium Ion Homeostasis Inflammatory Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Nitric Oxide Mediated Signal Transduction Brain Development Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Negative Regulation Of Heart Rate Negative Regulation Of Norepinephrine Secretion Cerebellar Cortex Development Negative Regulation Of Cell Growth Negative Regulation Of Icosanoid Secretion Positive Regulation Of Phosphoprotein Phosphatase Activity Intracellular Signal Transduction Regulation Of Metanephros Size Exploration Behavior Positive Regulation Of Renal Sodium Excretion Aldosterone Secretion Angiotensin-activated Signaling Pathway Dopamine Biosynthetic Process Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Dexamethasone Stimulus Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Extracellular Negative Regulation Of Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Metabolism of Angiotensinogen to Angiotensins G alpha (i) signalling events Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Cystic fibrosis severity ( 21602797)
Protein-Protein Interactions		22 interactors: ACE2 AGTR1 AGTR2 ATP6AP2 CMA1 CTSG DNPEP ECE1 ENPEP EWSR1 GRB2 GSDMB ITSN2 KNG1 MAS1 MEP1A MME PRCP PREP PRG2 REN TP53	11 interactors: ACE AGT AGTRAP ERBB2IP ERBB3 GNAI2 GNAI3 MTUS1 PIK3CB SNTA1 ZBTB16
Entrez ID		183	186
HPRD ID		00106	02071
Ensembl ID		ENSG00000135744	ENSG00000180772
Uniprot IDs		B0ZBE2 B2R5S1 P01019	P50052
PDB IDs		1N9U 1N9V 2JP8 2WXW 2X0B 4AA1 4APH 4FYS
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of Blood Pressure Peptide Hormone Processing Blood Circulation Peptide Metabolic Process Cellular Amide Metabolic Process Regulation Of Hormone Levels Hormone Metabolic Process Protein Processing Regulation Of Blood Volume By Renin-angiotensin Proteolysis Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin-activated Signaling Pathway Regulation Of Protein Metabolic Process Peptide Catabolic Process Regulation Of Renal Sodium Excretion Regulation Of Excretion Renal System Process Angiotensin Catabolic Process In Blood Regulation Of Metabolic Process Multicellular Organismal Protein Catabolic Process Kidney Development Multicellular Organismal Protein Metabolic Process Regulation Of Blood Vessel Size By Renin-angiotensin Renal System Development Regulation Of Vasodilation Urogenital System Development Regulation Of Vasoconstriction Drinking Behavior Brain Renin-angiotensin System Regulation Of Blood Vessel Size Regulation Of Tube Size System Development Positive Regulation Of Renal Sodium Excretion Organ Development Blood Coagulation, Intrinsic Pathway Regulation Of Inflammatory Response Negative Regulation Of Systemic Arterial Blood Pressure Replicative Senescence Regulation Of Signaling Extracellular Negative Regulation Of Signal Transduction Beta-amyloid Metabolic Process Digestion Protein Metabolic Process	Regulation Of Renal Output By Angiotensin Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Vasoconstriction Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Angiotensin Maturation Regulation Of Protein Kinase Activity Regulation Of Angiotensin Metabolic Process Regulation Of Blood Volume By Renin-angiotensin Regulation Of Kinase Activity Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Phosphorylation Cell Division Positive Regulation Of Protein Modification Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Adenylate Cyclase Activity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Lyase Activity Phosphatidylinositol 3-kinase Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Blood Pressure Regulation Of Protein Phosphorylation Negative Regulation Of CAMP Biosynthetic Process Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Wound Healing Peptide Hormone Processing Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Nucleotide Metabolic Process Regulation Of Immune System Process Regulation Of Phosphorylation Cell Activation Regulation Of Protein Metabolic Process Blood Vessel Remodeling Regulation Of Cellular Component Movement Regulation Of Vasodilation
Tagcloud ?		agc alleles amplified autophosphorylation berardinelli changing coding codon exons heterozygous iinsulin inheritance insulin lesion lipodystrophic lipodystrophy mellitus outside pathogenetic polymorphism polymorphisms recessive seip sequenced ser339 silent substitution unlikely val	ace acquired acquisition adjuvant agtr1 angiotensin blockers captopril continuously converting endocrine expressions innate losartan mcf mtt mumol phenotype prevention preventive problem qrt ras renin resistant reversion tam tamoxifen viability
Tagcloud (Difference) ?		agc alleles amplified autophosphorylation berardinelli changing coding codon exons heterozygous iinsulin inheritance insulin lesion lipodystrophic lipodystrophy mellitus outside pathogenetic polymorphism polymorphisms recessive seip sequenced ser339 silent substitution unlikely val	ace acquired acquisition adjuvant agtr1 angiotensin blockers captopril continuously converting endocrine expressions innate losartan mcf mtt mumol phenotype prevention preventive problem qrt ras renin resistant reversion tam tamoxifen viability
Tagcloud (Intersection) ?