ATN1 and AGRN

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATN1	AGRN
Gene Name		atrophin 1	agrin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cell Junction Perinuclear Region Of Cytoplasm	Extracellular Region Basal Lamina Extracellular Space Cytoplasm Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Extracellular Matrix Lysosomal Lumen Synapse Extracellular Vesicular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Toxin Receptor Binding	Dystroglycan Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Acetylcholine Receptor Regulator Activity Sialic Acid Binding Chondroitin Sulfate Binding Laminin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Central Nervous System Development Toxin Metabolic Process Cell Migration Maintenance Of Cell Polarity Neuron Apoptotic Process	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Plasma Membrane Organization Signal Transduction G-protein Coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Neuromuscular Junction Development Phototransduction, Visible Light Pathogenesis Regulation Of Receptor Activity Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Positive Regulation Of Rho GTPase Activity Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Clustering Of Voltage-gated Sodium Channels Neurotransmitter Receptor Metabolic Process Positive Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Transcription From RNA Polymerase II Promoter Synapse Organization Positive Regulation Of Filopodium Assembly
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis NCAM signaling for neurite out-growth MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism NCAM1 interactions Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		93 interactors: AES AGRN ALG13 ARF3 ATRX BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CENPJ CHRD CRACR2A CRIP2 CTNND2 DMPK DVL1 DVL2 ECM1 EFEMP1 EFEMP2 EWSR1 FBLN1 FBLN2 FBLN5 GAPDH GCC1 GIGYF1 GRN HINFP HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP4-12 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 PCSK5 PDCD6IP PFKL PLSCR1 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SIAH1 SIAH2 SLIT1 SPAG5 SSPO STXBP4 SYVN1 TEP1 TLE1 TRIP6 USP54 VIM WDR5 WWP1 WWP2 ZMYND8 ZSWIM8	5 interactors: ATN1 ATXN7 CACNA1A DAG1 GFI1B
Entrez ID		1822	375790
HPRD ID		06311	10550
Ensembl ID		ENSG00000111676	ENSG00000188157
Uniprot IDs		P54259 Q86V38	O00468
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Developmental Process Regulation Of Gene Expression Signaling Regulation Of Signaling Signal Transduction Nervous System Development Anatomical Structure Development Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Cellular Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Proteolysis Regulation Of RNA Biosynthetic Process System Development Response To Stimulus Cell Death Death Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Morphogenesis Modification-dependent Protein Catabolic Process Protein Catabolic Process Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Programmed Cell Death Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Biosynthetic Process Protein Ubiquitination Axon Development	Negative Regulation Of Cellular Metabolic Process Cerebellar Molecular Layer Development Nerve Maturation Calcium-dependent Cell-matrix Adhesion Vestibular Nucleus Development Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Commissural Neuron Axon Guidance Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Cytoskeletal Anchoring At Plasma Membrane Pons Development Maintenance Of Cell Polarity Negative Regulation Of Phosphorylation Toxin Metabolic Process Basement Membrane Organization Cerebellar Purkinje Cell Differentiation Regulation Of Metabolic Process Microtubule Cytoskeleton Organization Cerebellar Purkinje Cell Layer Morphogenesis Histone Deubiquitination Membrane Protein Ectodomain Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter System Development NLS-bearing Protein Import Into Nucleus Reflex Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Behavioral Response To Pain Modulation By Virus Of Host Morphology Or Physiology Regulation Of Histone H3-K4 Methylation Neuromuscular Synaptic Transmission Branching Involved In Salivary Gland Morphogenesis Regulation Of Hormone Biosynthetic Process Cell Morphogenesis Involved In Neuron Differentiation Cerebellar Cortex Formation Neurotransmitter Metabolic Process Chromatin Modification Gamma-aminobutyric Acid Signaling Pathway Cell Differentiation In Hindbrain Multicellular Organismal Development Neuron Projection Morphogenesis Calcium Ion Import
Tagcloud ?		atrophin1 atrophy chip cortical degenerative demethylase dentatorubral depletion h3k4 hint inducing knockout lbal lsd1 lysine maintenance methylation npc pallidoluysian phenocopied poorly precise premature progenitor repression rescued seq surprisingly tranylcypromine
Tagcloud (Difference) ?		atrophin1 atrophy chip cortical degenerative demethylase dentatorubral depletion h3k4 hint inducing knockout lbal lsd1 lysine maintenance methylation npc pallidoluysian phenocopied poorly precise premature progenitor repression rescued seq surprisingly tranylcypromine
Tagcloud (Intersection) ?