DYNC1H1 and FAM46A

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)

		DYNC1H1	FAM46A
Gene Name		dynein, cytoplasmic 1, heavy chain 1	family with sequence similarity 46, member A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Membrane Filopodium Extracellular Vesicular Exosome
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding ATPase Activity Poly(A) RNA Binding Dynein Light Intermediate Chain Binding	Poly(A) RNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transport Organelle Organization Microtubule-based Movement Mitotic Spindle Organization Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly	Regulation Of Gene Expression Regulation Of Blood Coagulation
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS			Breast cancer ( 22976474) Corneal structure ( 23291589) Height ( 20881960 23563607)
Protein-Protein Interactions		14 interactors: BRCA1 DISC1 DYNLL1 EGFR FAM46A KATNA1 KATNB1 NDEL1 PRKCD SMAD2 SNCA TNIK YWHAG YWHAQ	16 interactors: ATXN1 BAG6 BCCIP CD93 COL4A2 DYNC1H1 EGLN2 HDLBP HTRA1 KEAP1 NR2F2 PSG3 RNF14 SPINT1 TBX4 ZFYVE9
Entrez ID		1778	55603
HPRD ID		02524	13311
Ensembl ID		ENSG00000197102	ENSG00000112773
Uniprot IDs		Q14204	Q96IP4
PDB IDs		2BOR 2BOT
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway Developmental Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Intracellular Transport Regulation Of Cell Development Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Neuron Differentiation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Positive Regulation Of Cell Death Cell Cycle Process Nervous System Development Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Mitotic Cell Cycle Process Cellular Localization Regulation Of Neurogenesis Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Neuron Projection Development Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Transport Mitotic Cell Cycle Positive Regulation Of Organelle Organization Microtubule-based Process Protein Localization Regulation Of Intracellular Transport Multicellular Organismal Development Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Mitochondrion Organization Anatomical Structure Development Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Response To DNA Damage Stimulus Apoptotic Process Generation Of Neurons Regulation Of Cell Differentiation Microtubule Severing Programmed Cell Death Organelle Organization System Development Positive Regulation Of Apoptotic Process	Embryo Development Placenta Blood Vessel Development Intracellular Receptor Signaling Pathway Blood Vessel Development Vasculature Development Lung Development Respiratory Tube Development Radial Pattern Formation Respiratory System Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Anatomical Structure Development Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiovascular System Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Transcription, DNA-templated Blood Vessel Morphogenesis Dentinogenesis Proteasomal Ubiquitin-independent Protein Catabolic Process Embryonic Placenta Development Response To Estradiol RNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Tissue Development In Utero Embryonic Development Neuroendocrine Cell Differentiation Tail-anchored Membrane Protein Insertion Into ER Membrane Epithelium Development
Tagcloud ?		200x customized dcx depths exome flna funded heterotopia kif5c kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical tubb2b unequal	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Difference) ?		200x customized dcx depths exome flna funded heterotopia kif5c kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical tubb2b unequal	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Intersection) ?