AP2A1 and NUMB

Number of citations of the paper that reports this interaction (PMID 12942088)
54

Data Source:
HPRD (in vivo)

		AP2A1	NUMB
Gene Name		adaptor-related protein complex 2, alpha 1 subunit	numb homolog (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Nucleus Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Notch Signaling Pathway Axon Guidance Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Positive Regulation Of Polarized Epithelial Cell Differentiation Adherens Junction Organization Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Neurogenesis Lung Epithelial Cell Differentiation Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses	Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH L1CAM interactions Recycling pathway of L1 Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Degradation of GLI1 by the proteasome Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS			Bipolar disorder (mood-incongruent) ( 23092984) Coronary artery calcification ( 17903303)
Protein-Protein Interactions		27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1	24 interactors: AP2A1 AP2A2 APP DPYSL2 EGFR EPS15 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MDM2 NOTCH1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ RPL3 SIAH1
Entrez ID		160	8650
HPRD ID		03016	04767
Ensembl ID		ENSG00000196961	ENSG00000133961
Uniprot IDs		O95782	P49757
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Blood Coagulation Hemostasis Response To Growth Factor Wound Healing Platelet Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Activation Response To Wounding Regulation Of Immune System Process Regulation Of Body Fluid Levels Immune System Process Cell Surface Receptor Signaling Pathway Response To External Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Signaling Regulation Of Phospholipase Activity Chemotaxis Positive Regulation Of Lipase Activity Neuron Projection Morphogenesis Signal Transduction Cellular Response To Organic Substance Signaling Response To Organic Substance Axonogenesis Defense Response Activation Of Phospholipase C Activity Cell Communication Cellular Response To Stimulus Axon Development Neuron Projection Development Innate Immune Response Negative Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Phospholipase C Activity Regulation Of Cellular Amino Acid Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Part Morphogenesis Negative Regulation Of Signaling Response To Stimulus
Tagcloud ?			adapter affinities arise asymmetric bind bond contain diverse division domain gp gppy helical hydrogen ldnpay library lnx modes motif nak nmr npxy peptide phosphotyrosine ptb reveals sheet turn y
Tagcloud (Difference) ?			adapter affinities arise asymmetric bind bond contain diverse division domain gp gppy helical hydrogen ldnpay library lnx modes motif nak nmr npxy peptide phosphotyrosine ptb reveals sheet turn y
Tagcloud (Intersection) ?