CTSL and CSTA

Number of citations of the paper that reports this interaction (PMID 9585570)
7

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		CTSL	CSTA
Gene Name		cathepsin L	cystatin A (stefin A)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Endolysosome Lumen Lysosomal Lumen Extracellular Vesicular Exosome	Cornified Envelope Extracellular Space Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding	Protease Binding Cysteine-type Endopeptidase Inhibitor Activity Structural Molecule Activity Protein Binding, Bridging
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Single Organismal Cell-cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis
Pathways		Collagen formation Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Calcium levels ( 20705733)
Protein-Protein Interactions		27 interactors: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG	12 interactors: CTSB CTSH CTSL DSP EVPL IVL KRT1 LOR PI3 PTN UCHL5 ZDHHC17
Entrez ID		1514	1475
HPRD ID		00293	01697
Ensembl ID		ENSG00000135047	ENSG00000121552
Uniprot IDs		P07711 Q9HBQ7	P01040 Q6IB90
PDB IDs		1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM	1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Protein Insertion Into ER Membrane Immune Response Regulation Of Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Cell Death Adaptive Immune Response Protein Insertion Into Membrane Positive Regulation Of Neutrophil Chemotaxis Immune System Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Cell Migration Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Regulation Of Cell Motility T Cell Mediated Immunity Regulation Of Granulocyte Chemotaxis Regulation Of Locomotion Cell Activation Positive Regulation Of Histone Methylation Regulation Of Cellular Component Movement Response To Abiotic Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Endoplasmic Reticulum Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Methylation Negative Regulation Of Blood Coagulation	Peptide Cross-linking Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Skin Development Keratinocyte Differentiation Epidermal Cell Differentiation Organ Development Keratinization Epithelial Cell Differentiation Tissue Development Epithelium Development Epidermis Development Protein Metabolic Process System Development Multicellular Organismal Development Anatomical Structure Development Developmental Process Cellular Protein Metabolic Process Collagen Catabolic Process Regulation Of Immune Response Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Regulation Of Endopeptidase Activity Multicellular Organismal Metabolic Process Regulation Of Peptidase Activity Extracellular Matrix Disassembly Ventricular Compact Myocardium Morphogenesis Neuropeptide Catabolic Process Macrophage Apoptotic Process Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Localization To Adherens Junction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteolysis Involved In Cellular Protein Catabolic Process Activation Of Innate Immune Response Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hormone Stimulus Bradykinin Catabolic Process Immune Response Regulation Of Immune System Process Protein Catabolic Process Positive Regulation Of Immune Response Tissue Homeostasis Positive Regulation Of Innate Immune Response Myeloid Cell Apoptotic Process Complement Activation, Lectin Pathway
Tagcloud ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	abcc3 abcc5 amphiregulin areg ccna2 ctsd cycloheximide dissimilar dleu2 efna1 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Difference) ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	abcc3 abcc5 amphiregulin areg ccna2 cycloheximide dissimilar dleu2 efna1 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Intersection) ?		ctsd