WIPF2 and WAS

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
HPRD (in vitro, in vivo)

		WIPF2	WAS
Gene Name		WAS/WASL interacting protein family, member 2	Wiskott-Aldrich syndrome
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton	Cytosol Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding	Actin Binding Small GTPase Regulator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Identical Protein Binding Phospholipase Binding
	Biological Process	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response	Protein Complex Assembly Defense Response Immune Response Blood Coagulation Actin Polymerization Or Depolymerization Epidermis Development Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	TCR signaling Generation of second messenger molecules Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APBB1 DNMBP GRB2 ITSN2 NCK2 PFN1 TCERG1 WAS WASL WWOX	53 interactors: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 ENAH EVL FCHSD2 FGR FYB FYN GAS7 GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RGS14 RHOJ SORBS2 SRC TCERG1 TEC TNK2 TRIP10 VASP WBP4 WIPF1 WIPF2
Entrez ID		147179	7454
HPRD ID		18304	02314
Ensembl ID		ENSG00000171475	ENSG00000015285
Uniprot IDs		A8MWR2 Q8TF74	P42768
PDB IDs			1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Positive Regulation Of Cellular Component Biogenesis Regulation Of Metabolic Process Positive Regulation Of Actin Filament Polymerization Axon Guidance Positive Regulation Of Protein Polymerization Regulation Of Organelle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Nucleation Positive Regulation Of Protein Complex Assembly Axonogenesis Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Chemotaxis Actin Cytoskeleton Organization Neuron Projection Morphogenesis Actin Filament-based Process Positive Regulation Of Metabolic Process Endocytosis Cell Activation Regulation Of Catalytic Activity Phagocytosis Cell Morphogenesis Involved In Differentiation Vesicle-mediated Transport Anatomical Structure Morphogenesis Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Neuron Projection Development Cell Projection Morphogenesis Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Cell Part Morphogenesis Actin Filament-based Movement Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway	Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Locomotion Axon Guidance Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Filament Organization Innate Immune Response Chemotaxis Positive Regulation Of Actin Filament Polymerization Axonogenesis Neuron Projection Morphogenesis Immune Response Positive Regulation Of Protein Polymerization Enzyme Linked Receptor Protein Signaling Pathway Axon Development Actin Cytoskeleton Organization Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Cell Surface Receptor Signaling Pathway Endocytosis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Length Neuron Projection Development Regulation Of Cellular Component Organization Antigen Receptor-mediated Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Signal Transduction T Cell Receptor Signaling Pathway Signaling
Tagcloud ?		arg35 arhg5 cbl cblb del digested downscaled doxycycline dyn2 errfi flp hek293 hsp71 hsp7c input irs4 l747 optimisation pc9 ptpra purifications quantities retroviral s752 sos1 sos2 tagged tap usb3b
Tagcloud (Difference) ?		arg35 arhg5 cbl cblb del digested downscaled doxycycline dyn2 errfi flp hek293 hsp71 hsp7c input irs4 l747 optimisation pc9 ptpra purifications quantities retroviral s752 sos1 sos2 tagged tap usb3b
Tagcloud (Intersection) ?