CSNK2A1 and CALM1

Number of citations of the paper that reports this interaction (PMID 8206911)
10

Data Source:
HPRD (in vivo, in vitro)

		CSNK2A1	CALM1
Gene Name		casein kinase 2, alpha 1 polypeptide	calmodulin 1 (phosphorylase kinase, delta)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Sin3 Complex NuRD Complex PcG Protein Complex	Spindle Pole Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Spindle Microtubule Plasma Membrane Sarcomere Growth Cone Vesicle Calcium Channel Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding Hsp90 Protein Binding	Calcium Ion Binding Protein Binding Adenylate Cyclase Binding Protein Kinase Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Titin Binding Type 3 Metabotropic Glutamate Receptor Binding Thioesterase Binding N-terminal Myristoylation Domain Binding Phospholipase Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Ion Channel Binding Calcium-dependent Protein Binding Nitric-oxide Synthase Binding Protein Phosphatase Activator Activity
	Biological Process	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Axon Guidance Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Growth Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Chaperone-mediated Protein Folding Mitotic Spindle Checkpoint	Response To Amphetamine Regulation Of Heart Rate Platelet Degranulation Detection Of Calcium Ion Carbohydrate Metabolic Process Glycogen Catabolic Process Glucose Metabolic Process Muscle Contraction Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Rhodopsin Mediated Signaling Pathway Substantia Nigra Development Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Protein Autophosphorylation Regulation Of Cytokinesis Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Fc-epsilon Receptor Signaling Pathway Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Nitric Oxide Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Corticosterone Response To Calcium Ion Regulation Of Cardiac Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Membrane Organization Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Ca-dependent events CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by Wnt Platelet degranulation Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras PLCG1 events in ERBB2 signaling Glucose metabolism DAP12 signaling Synthesis of IP3 and IP4 in the cytosol Myoclonic epilepsy of Lafora Response to elevated platelet cytosolic Ca2+ Glycogen storage diseases Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Signaling by PDGF Calmodulin induced events CaMK IV-mediated phosphorylation of CREB DAP12 interactions Glycogen breakdown (glycogenolysis) Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Inositol phosphate metabolism EGFR interacts with phospholipase C-gamma CaMK IV-mediated phosphorylation of CREB Signaling by ERBB2 Signaling by EGFR Signaling by VEGF CREB phosphorylation through the activation of CaMKK Downstream signal transduction Calmodulin induced events CREB phosphorylation through the activation of CaMKII Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Transcriptional activation of mitochondrial biogenesis Metabolism of carbohydrates Platelet activation, signaling and aggregation Adaptive Immune System Transmission across Chemical Synapses Ras activation uopn Ca2+ infux through NMDA receptor Organelle biogenesis and maintenance Cam-PDE 1 activation Translocation of GLUT4 to the plasma membrane VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Inactivation, recovery and regulation of the phototransduction cascade Metabolism of nitric oxide VEGFR2 mediated cell proliferation VEGFR2 mediated vascular permeability Activation of NMDA receptor upon glutamate binding and postsynaptic events The phototransduction cascade Downstream signaling of activated FGFR DARPP-32 events eNOS activation and regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Post NMDA receptor activation events Signalling by NGF PLC beta mediated events Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Mitochondrial biogenesis beta-catenin independent WNT signaling Signaling by FGFR eNOS activation Cam-PDE 1 activation Ca2+ pathway Visual phototransduction Activation of CaMK IV PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs		(5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One Resveratrol 1,8-Di-Hydroxy-4-Nitro-Anthraquinone Benzamidine 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone Phosphoaminophosphonic Acid-Adenylate Ester Tetrabromo-2-Benzotriazole DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one N,N\'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE 2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole 1,2,5,8-tetrahydroxyanthracene-9,10-dione Ellagic Acid
Diseases
GWAS
Protein-Protein Interactions		366 interactors: ABCA1 ACACA ACAT2 ACE ACIN1 AIP AKAP8 AKT1 ALKBH5 ANP32B APC APEX1 APOE APP AQP4 ARL6IP4 ARMCX3 ARNT ARR3 ARRB2 ASIC3 ATF1 ATF2 ATP2B1 ATP5A1 BCLAF1 BDP1 BID BIRC6 BMS1 BRCA1 BRF1 C1orf109 C1R CALM1 CALU CANX CARD9 CASP2 CASQ2 CAV1 CAV2 CCDC6 CD2BP2 CD5 CDC25B CDC37 CDH1 CDK1 CDKN1A CFDP1 CHD4 CHUK CIRBP CLASP2 CLNS1A CLTB COPS2 COPS3 COPS7A CPSF6 CPSF7 CREBBP CREM CSN1S1 CSN2 CSNK2B CTDP1 CTNNB1 CUX2 CXCL8 DDIT3 DDX17 DDX21 DDX24 DDX3X DDX54 DEK DHX16 DHX38 DKC1 DTD1 DVL1 DVL3 EEF1B2 EEF1D EGR1 EIF2B5 EIF2S1 EIF2S2 EIF3J EIF4B EIF4EBP1 EIF5 EIF5B ERH EXOSC9 F11R F5 FAF1 FCP1 FGF1 FGF2 FIBP FIP1L1 FKBP3 FKBP4 FLG FNBP4 FOS FTSJ3 FXR1 GABRR1 GABRR2 GAP43 GGA1 GMFB GMNN GPI GPN1 GTF2A1 GTF2A1L GTF2F1 GYS1 HCLS1 HDAC1 HDAC2 HDAC3 HDGFRP2 HDLBP HES6 HIF1A HIRIP3 HMGA1 HMGA2 HMOX2 HNRNPA2B1 HNRNPC HNRNPDL HNRNPL HOXB7 HSF1 HSP90AA1 HSP90AB1 HSP90B1 HSPA4 HSPB8 HSPH1 HTATSF1 IFI16 IFRD1 IGF2R IGFBP3 IL16 INF2 IRF2 IRS1 ITCH IWS1 JUN KANK2 KIF1C KIF5C KLF1 KPNA4 L1CAM LARP1 LARP7 LEO1 LGALS3 LIG1 LRRC59 LSM14A LTV1 MAF1 MAGEA11 MAK16 MAPK14 MAPT MAX MAZ MCM2 MCM3 MDC1 MEF2C MFAP1 MGMT MME MPHOSPH10 MRPL38 MRPL4 MS4A1 MSH6 MTDH MYB MYC MYCN MYF5 MYH9 NAF1 NAP1L4 NCAPD2 NCL NCOR1 NFKBIA NFKBIB NFYA NKX2-5 NMD3 NMT1 NOL3 NOLC1 NOP56 NOP58 NPM1 NRF1 NUP98 NXF1 OGT OSBP PACS1 PAFAH1B1 PAK1 PDAP1 PDCD4 PDIA6 PGR PIAS1 PIN1 PIN4 PLEKHO1 PML PNN POLR2A PPAN PPBP PPP1R1B PPP1R2 PPP1R8 PPP2R4 PRCC PRKACB PRNP PRPF38A PRPF40A PSEN2 PSIP1 PSMA3 PSMA4 PTEN PTPN1 PTPRC PURB RANGAP1 RBM10 RBM17 RBM33 RBMX RELA RGS19 RIOK2 RNF111 RNF7 RPL13 RPL5 RPL6 RPLP0 RPLP1 RPRD2 RPS18 RPS3 RPS6KB1 RRAD RRP12 RRP1B RRP9 RSF1 RSL1D1 SAFB SAP30BP SAT1 SCNN1A SEPT2 SERBP1 SERPINF1 SF3A1 SF3B1 SF3B2 SFPQ SHOX SLC18A2 SLC4A1AP SLIRP SMARCC2 SNCA SND1 SNRNP70 SP1 SPATS2L SPI1 SPIB SPP1 SPTBN1 SQSTM1 SREK1 SRF SRRM1 SRRM2 SRRT SRSF10 SRSF11 SRSF2 SSB SSRP1 STAC3 STMN1 STX1A SUB1 SUDS3 SUGT1 SUPT5H SUPT6H SURF6 TCF7L2 TH THAP1 THOC5 THRAP3 TMOD3 TMPO TNKS1BP1 TNP1 TOP1 TOP2A TP53 TSPY1 UBAC1 UBE2R2 UBTF USP24 UTP14A UTP18 VAMP4 VDR VHL VTN WAS WDR44 WDR55 WEE1 XK XKRY XRCC1 XRCC4 XRCC5 XRCC6 XRN2 YBX1 YWHAB YWHAQ ZC3H13 ZC3H15 ZC3H8 ZFC3H1 ZHX1 ZRANB2	232 interactors: ACADM ADCY8 ADCYAP1R1 ADD1 ADD2 AKAP5 AKAP6 AKAP9 AR ARHGEF7 ARMC1 ASCL2 ATP2B1 ATRX BRWD1 C11orf65 CABIN1 CALCR CALD1 CAMK1 CAMK2G CAMKK1 CAMKK2 CASP8AP2 CCDC14 CCNA2 CCND1 CCND2 CCNE1 CCP110 CDC37L1 CDC5L CKMT1B CLINT1 CLIP1 CLTB CNGA2 CNN1 CRHR1 CSNK2A1 CSNK2A2 CSNK2B DAPK1 DCTN2 DCUN1D1 DDAH1 DDX21 DDX5 DLG3 DMXL1 DNAJC13 DOCK11 DOCK3 DRD2 DST EDF1 EGFR EIF3C ESR1 ESR2 ESRRG EWSR1 FAM178A FAS FBXO9 FER FKBP3 FKBP4 GAP43 GCLM GJB1 GLP1R GLP2R GNAS GRB7 GRIN1 GRK1 GRK4 GRK5 GRM3 GRM4 GRM5 GRM7 GTF2I H2AFX HERC2 HMMR HSP90AA1 HSPA4 HTR2C HUWE1 IMMT INSR IQGAP1 IQGAP2 ITGA6 ITPKA ITPKB KCNH1 KCNN2 KCNN3 KCNN4 KCNQ2 KCNQ3 KCNQ5 KDM5C KIAA0020 KIAA1683 KIF1B KRAS LACTB LMO7 LTF LUC7L LY96 LYST MAPT MATR3 MBIP METAP2 MIP MORF4L1 MYBPC1 MYCBP2 MYF5 MYF6 MYLK MYO10 MYO7A MYO9B MYOD1 MYOG NBR1 NEB NEUROD1 NEXN NOL7 NOS3 NR3C1 NRGN NT5C2 OBSCN OPALIN OPRM1 OPTN PAM PCNT PCP4 PDCD7 PDE1A PHACTR4 PHKG1 PIK3C3 PLCD1 POLR2B PPEF1 PPEF2 PPIL2 PRDX1 PSMD12 PSMD2 PTAFR PTH2R PTPRA RAB3B RAD23B RALA RALB RANBP2 RDX REL RELA RGS10 RGS2 RGS4 RIT2 RPL13A RPL22 RPS14 RPS15A RPS4Y1 RPS8 RRAD RYR1 RYR2 S100B SCAPER SCLT1 SCN4A SCN5A SCTR SEC61A1 SET SF3B1 SLTM SNCA SNRPB2 SNTA1 SNX6 SPP1 SQSTM1 SRP14 SRSF5 STAG1 STIM2 STK38 STRN STRN3 STRN4 STX8 SYK SYNE2 SYT1 TCF3 TCF4 THOP1 TNNI2 TPT1 TRDN TRPC3 TRPV1 TRPV4 TRPV6 TSC2 TTN UCHL5 USP16 VIPR1 XRCC4 YBX1 YWHAE ZBTB24
Entrez ID		1457	801
HPRD ID		00277	00241
Ensembl ID			ENSG00000198668
Uniprot IDs		P68400	B4DJ51 E7ETZ0 P62158
PDB IDs		1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 4DGL 4FBX 4GRB 4GYW 4GYY 4GZ3 4IB5	1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M55 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4DCK 4DJC 4GOW
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process MRNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Processing Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process MRNA Processing Biosynthetic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Cellular Process Regulation Of RNA Metabolic Process Response To Stress RNA Splicing Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Developmental Process Regulation Of Transcription, DNA-templated Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Response To Organic Substance Programmed Cell Death Death Viral Process Cell Death Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process	Response To Stimulus Regulation Of Cellular Process Cell Communication Signaling Cellular Response To Stimulus Regulation Of Signaling Signal Transduction Response To Organic Substance Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Cell Differentiation Response To External Stimulus Regulation Of Signal Transduction Developmental Process Regulation Of Catalytic Activity Cellular Process Response To Stress Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Organic Cyclic Compound System Development Regulation Of Ion Transport Multicellular Organismal Development Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Localization Synaptic Transmission Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Regulation Of Phosphorylation Locomotion Regulation Of Cellular Localization Positive Regulation Of Cellular Biosynthetic Process Muscle System Process Intracellular Transport Regulation Of Ion Transmembrane Transport Cytoplasmic Transport Movement Of Cell Or Subcellular Component Chemotaxis Regulation Of Cellular Component Organization Nervous System Development Regulation Of Protein Kinase Activity Generation Of Neurons
Tagcloud ?		bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis	considering dysregulated endocrine ep300 facilitates geo give hope hub omnibus partial pls posttraumatic prkca psychological ptsd recovered representations shed signatures square squares supports theoretical top trauma traumatic underlie variance
Tagcloud (Difference) ?		bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis	considering dysregulated endocrine ep300 facilitates geo give hope hub omnibus partial pls posttraumatic prkca psychological ptsd recovered representations shed signatures square squares supports theoretical top trauma traumatic underlie variance
Tagcloud (Intersection) ?