CSNK1A1 and GLI3

Number of citations of the paper that reports this interaction (PMID 16371461)
56

Data Source:
BioGRID (enzymatic study)

		CSNK1A1	GLI3
Gene Name		casein kinase 1, alpha 1	GLI family zinc finger 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Nuclear Speck Primary Cilium	Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Mediator Complex Nuclear Speck Transcriptional Repressor Complex Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Phagocytosis Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Transcription, DNA-templated Smoothened Signaling Pathway Axon Guidance Hindgut Morphogenesis Heart Development Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Protein Processing Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex Radial Glia Guided Migration Forebrain Radial Glial Cell Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Wound Healing Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Response To Estrogen Negative Thymic T Cell Selection Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Skeletal System Morphogenesis Oligodendrocyte Differentiation Palate Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome Activation of SMO	Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 is processed to GLI3R by the proteasome
Drugs
Diseases
GWAS		Esophageal cancer ( 21642993)	Age-related macular degeneration ( 23326517) Allergic rhinitis ( 22036096)
Protein-Protein Interactions		43 interactors: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 PARK2 PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 RCC1 SLC18A2 SNCA SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 YWHAQ YWHAZ	17 interactors: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TWIST1 ZIC1 ZIC2 ZIC3
Entrez ID		1452	2737
HPRD ID		02739	01313
Ensembl ID		ENSG00000113712	ENSG00000106571
Uniprot IDs		B4DER9 P48729 Q6PJ06 Q71TU5	P10071
PDB IDs
Enriched GO Terms of Interacting Partners?		Death Apoptotic Process Programmed Cell Death Cell Death Cellular Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Positive Regulation Of Cell Death Response To Organic Substance Response To Stimulus Cell Communication Regulation Of Apoptotic Process Response To Stress Regulation Of Cell Death Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Transport Execution Phase Of Apoptosis Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Death Immune System Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Establishment Of Protein Localization Developmental Process Thymus Development Regulation Of Catalytic Activity Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Leukocyte Activation Positive Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component	Embryonic Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Tube Morphogenesis Tissue Morphogenesis Positive Regulation Of Transcription, DNA-templated Tube Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Embryo Development Epithelial Tube Morphogenesis Organ Development SMAD Protein Complex Assembly Pattern Specification Process Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Cell Differentiation Epithelium Development Positive Regulation Of Cellular Metabolic Process Heart Development Morphogenesis Of An Epithelium Regulation Of Cell Differentiation Regulation Of Signal Transduction Cardiovascular System Development Tissue Development Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Stem Cell Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter System Development Regulation Of Transcription, DNA-templated Stem Cell Maintenance Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Developmental Process Stem Cell Differentiation Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Transcription From RNA Polymerase II Promoter Response To Growth Factor Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Primary MiRNA Processing
Tagcloud ?		aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt	act antitumor application blocks cancers combined component could cyclopamine directions downstream enhance glioma gynecological hedgehog induce leading malignancy management mortality oncogene ovarian pathway proliferation reduce signaling silencing therefore
Tagcloud (Difference) ?		aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt	act antitumor application blocks cancers combined component could cyclopamine directions downstream enhance glioma gynecological induce leading malignancy management mortality oncogene ovarian pathway proliferation reduce signaling silencing therefore
Tagcloud (Intersection) ?		hedgehog