ZFP28 and PRKRA

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZFP28	PRKRA
Gene Name		ZFP28 zinc finger protein	protein kinase, interferon-inducible double stranded RNA dependent activator
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding	Protein Binding Enzyme Activator Activity Protein Homodimerization Activity Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Protein Phosphorylation Immune Response Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Production Of SiRNA Involved In RNA Interference Cellular Response To Oxidative Stress Outer Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Catalytic Activity Skeletal System Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Generic Transcription Pathway	Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS			Multiple sclerosis (OCB status) ( 23472185)
Protein-Protein Interactions		5 interactors: C8orf33 HMOX2 KDM1A PPP2CB PRKRA	21 interactors: AGO2 CEBPZ COPS6 DICER1 EIF2AK2 GDF9 KIAA1377 LYAR NKRF POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746
Entrez ID		140612	8575
HPRD ID		15725	04573
Ensembl ID		ENSG00000196867	ENSG00000180228
Uniprot IDs		Q8NHY6	B4DJC7 O75569
PDB IDs		2EM2 2EM3 2EM4 2EMJ 2EMK 2EML 2EN9 2ENH 2EOH 2EP0 2EPX 2EPZ 2YTM	2DIX
Enriched GO Terms of Interacting Partners?		Response To Oxidative Stress Regulation Of Primitive Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Stress Heme Oxidation Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Heme Catabolic Process Outer Ear Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Hormone Biosynthetic Process Production Of SiRNA Involved In RNA Interference Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator RNA Interference Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Middle Ear Morphogenesis Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hormone Metabolic Process Histone Lysine Demethylation Regulation Of Signal Transduction Histone Demethylation Regulation Of Erythrocyte Differentiation Heme Metabolic Process Cellular Response To DsRNA Protein Demethylation Posttranscriptional Gene Silencing Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of DNA Binding Regulation Of Signaling Porphyrin-containing Compound Metabolic Process Cellular Protein Modification Process Regulation Of Histone Methylation Positive Regulation Of Neural Precursor Cell Proliferation Pituitary Gland Development Negative Regulation Of Protein Binding	RNA Interference Pre-miRNA Processing Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Posttranscriptional Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Silencing By MiRNA Targeting Of MRNA For Destruction Involved In RNA Interference Cellular Response To DsRNA Regulation Of Gene Expression Posttranscriptional Gene Silencing Gene Expression Production Of SiRNA Involved In RNA Interference Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Viral Process Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Gene Silencing By RNA Glial Cell Apoptotic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To DsRNA Regulation Of Viral Genome Replication Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA 3'-end Processing Gene Silencing Regulation Of Translation Viral Process Regulation Of Metabolic Process Regulation Of MRNA 3'-end Processing ER-nucleus Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Growth Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?			1q21 5q31 6p21 alleles anxa6 applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic psoriasis rarely shared th2 tnip1 traits unreported utilizing
Tagcloud (Difference) ?			1q21 5q31 6p21 alleles anxa6 applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic psoriasis rarely shared th2 tnip1 traits unreported utilizing
Tagcloud (Intersection) ?