CREBBP and CTNNB1

Number of citations of the paper that reports this interaction (PMID 16476742)
83

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		CREBBP	CTNNB1
Gene Name		CREB binding protein	catenin (cadherin-associated protein), beta 1, 88kDa
Image
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nuclear Chromatin Condensed Chromosome Outer Kinetochore Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Nuclear Body	Spindle Pole Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytoplasm Centrosome Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Cell-cell Adherens Junction Fascia Adherens Tight Junction Focal Adhesion Cell Cortex Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Lamellipodium Cell Junction Beta-catenin Destruction Complex Microvillus Membrane Protein-DNA Complex Scrib-APC-beta-catenin Complex Dendritic Shaft Apical Part Of Cell Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Beta-catenin-TCF7L2 Complex Cell Periphery
	Molecular Function	Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription P53 Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity MRF Binding	RNA Polymerase II Activating Transcription Factor Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Signal Transducer Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Enzyme Binding Kinase Binding Protein Phosphatase Binding Estrogen Receptor Binding Protein Complex Binding Ionotropic Glutamate Receptor Binding Nuclear Hormone Receptor Binding Transcription Regulatory Region DNA Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding SMAD Binding Androgen Receptor Binding Nitric-oxide Synthase Binding I-SMAD Binding R-SMAD Binding Repressing Transcription Factor Binding Euchromatin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Chromatin Organization Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Complex Assembly Signal Transduction Notch Signaling Pathway Regulation Of Smoothened Signaling Pathway Gene Expression Viral Process Histone Acetylation N-terminal Peptidyl-lysine Acetylation Germ-line Stem Cell Maintenance Positive Regulation Of Type I Interferon Production Cellular Response To Heat Homeostatic Process Embryonic Digit Morphogenesis Cellular Lipid Metabolic Process Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Regulation Of Cellular Response To Heat	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Axis Specification Patterning Of Blood Vessels Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Cell Fate Specification Endodermal Cell Fate Commitment Neuron Migration Epithelial To Mesenchymal Transition Neural Plate Development Liver Development Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Morphogenesis In Camera-type Eye Regulation Of Secondary Heart Field Cardioblast Proliferation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Cell-matrix Adhesion Ectoderm Development Glial Cell Fate Determination Midgut Development Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Proximal/distal Pattern Formation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Schwann Cell Proliferation Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Stem Cell Maintenance Layer Formation In Cerebral Cortex Central Nervous System Vasculogenesis Osteoclast Differentiation Androgen Receptor Signaling Pathway Male Genitalia Development Regulation Of Centriole-centriole Cohesion Pancreas Development Hair Follicle Morphogenesis Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Type I Interferon Production T Cell Differentiation In Thymus Negative Regulation Of Protein Sumoylation Response To Cytokine Adherens Junction Assembly Protein Localization To Cell Surface Embryonic Heart Tube Development Genitalia Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Embryonic Skeletal Limb Joint Morphogenesis Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Response To Drug Regulation Of Cell Fate Specification Muscle Cell Differentiation Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Innate Immune Response Myoblast Differentiation Bone Resorption Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Mitotic Cell Cycle, Embryonic Response To Cadmium Ion Regulation Of Fibroblast Proliferation Cell Maturation Synaptic Vesicle Transport Thymus Development Oocyte Development Embryonic Foregut Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Oligodendrocyte Differentiation Synapse Organization Smooth Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Protein Heterooligomerization Positive Regulation Of Histone H3-K4 Methylation Oviduct Development Canonical Wnt Signaling Pathway Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Cell Differentiation Lung-associated Mesenchyme Development Lung Induction Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Hair Follicle Placode Formation Mesenchymal Cell Proliferation Involved In Lung Development Endothelial Tube Morphogenesis Fungiform Papilla Formation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Sympathetic Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Mechanical Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Renal Vesicle Formation Renal Inner Medulla Development Renal Outer Medulla Development Nephron Tubule Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Cellular Response To Insulin-like Growth Factor Stimulus Regulation Of Protein Localization To Cell Surface Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by Wnt Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 in Cancer Orphan transporters Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by NOTCH1 PEST Domain Mutants in Cancer Activation of gene expression by SREBF (SREBP) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants PPARA activates gene expression Cellular response to hypoxia Organelle biogenesis and maintenance Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Attenuation phase HATs acetylate histones RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) HSF1-dependent transactivation TRAF3-dependent IRF activation pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Pre-NOTCH Expression and Processing Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Innate Immune System FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Cytosolic sensors of pathogen-associated DNA Cellular response to heat stress REV-ERBA represses gene expression Mitochondrial biogenesis Notch-HLH transcription pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT TRAF6 mediated IRF7 activation YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by WNT in cancer BMAL1:CLOCK,NPAS2 activates circadian gene expression	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Innate Immune System truncations of AMER1 destabilize the destruction complex CDO in myogenesis misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Cytosolic sensors of pathogen-associated DNA formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway Myogenesis AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs			Urea
Diseases
GWAS		Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) QT interval (interaction) ( 23459443)	Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982)
Protein-Protein Interactions		253 interactors: ACTA2 ACVR1 AIRE AKT1 ALX1 ANAPC5 ANAPC7 AP1B1 APC AR ATF1 ATF3 BCL3 BCL6 BRCA1 CALCOCO1 CAMK4 CARM1 CDC25B CDH2 CDK5RAP3 CDX2 CEBPA CEBPB CEBPD CENPJ CHUK CITED1 CITED2 CNOT3 CNTN2 CREB1 CREM CRX CSK CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CUX1 DACH1 DAXX DDX17 DDX5 DEK E2F1 E2F3 E2F5 EBF1 EGR1 EID1 EID3 EIF2B1 ELF3 ELK1 EP300 ESR1 ETS1 ETS2 EWSR1 FGFR1 FHL2 FOS FOXM1 FOXO1 FOXO4 GABPA GAK GATA1 GCM1 GLI3 GMEB1 GMEB2 GTF2B H3F3A HBP1 HCK HDAC1 HDAC3 HIF1A HIPK2 HIST1H2BB HIST1H3A HIST1H4A HIST2H2BE HIST3H3 HIST4H4 HLF HMGA1 HMGB1 HMGB2 HNF1A HNF1B HNF4A HOXA10 HOXA11 HOXA9 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD12 HOXD13 HOXD4 HSF1 HTT IKBKG IRF1 IRF3 IRF5 IRF7 JDP2 JUN KAT2A KAT2B KAT5 KAT6A KDM3B KHDRBS1 KLF1 KLF13 KLF4 KLF5 KMT2A KPNA2 KPNA6 LDLR LIG4 LYN MAF MAFG MAML1 MAML2 MAP3K5 MAPK1 MAPK10 MAPK3 MBD2 MDC1 MDM2 MECOM MED25 MGMT MIER1 MKNK1 MSH2 MSH6 MSX1 MYB MYBL1 MYBL2 MYC MYOD1 N4BP2 NAP1L1 NCOA1 NCOA2 NCOA3 NCOA6 NEUROG1 NFATC2 NFATC4 NFE2 NFE2L2 NFIA NFIC NKX2-1 NLK NPAS2 NPAT NR3C1 NR5A1 NUP98 ONECUT1 PARP1 PAX5 PBX1 PCMT1 PELP1 PHOX2A PIAS1 PLAGL1 PML POLR2A POU1F1 POU2F3 PPARG PPARGC1A PRKCD PRLR PROX1 PSME3 PTMA RAD23A RBBP4 RBBP7 RBCK1 RELA RPS6KA1 RPS6KA3 RPS6KA5 RXRG SERTAD1 SERTAD2 SERTAD3 SH3GL1 SMAD2 SMAD3 SMAD4 SND1 SNIP1 SOX9 SPI1 SPIB SRCAP SREBF1 SREBF2 SRF SS18L1 STAT1 STAT2 STAT3 STAT4 STAT6 SUV39H1 TACC2 TAF6L TCF12 TCF3 TDG TFDP1 TGS1 THRA TP53 TP73 TRERF1 TRIP10 TRIP4 UBE2D1 UBE2I UBTF VDR WT1 XAF1 XRCC6 YWHAH ZBTB17 ZBTB2 ZNF639	172 interactors: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCND1 CDC27 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBB2IP ESR1 EZR FER FHIT FHL2 FLT1 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B HDAC6 HIF1A HIST1H1C HNF1A IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAPK8 MAPK9 MEN1 MET MITF MUC1 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NOTCH1 NR5A1 PECAM1 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKP2 PLK1 PPM1A PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RBX1 RUVBL1 RUVBL2 RXRA SALL1 SIAH1 SKP1 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SOX1 SOX17 SPN SRC TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIP10 TRRAP UBE2B UBE2D1 UHRF2 USP9X ZFYVE9
Entrez ID		1387	1499
HPRD ID		02534	00286
Ensembl ID		ENSG00000005339	ENSG00000168036
Uniprot IDs		Q92793	P35222
PDB IDs		1JSP 1LIQ 1RDT 1WO3 1WO4 1WO5 1WO6 1WO7 1ZOQ 2D82 2KJE 2KWF 2L84 2L85 2LXS 2LXT 2RNY 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K	1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Organ Development Multicellular Organismal Development System Development Anatomical Structure Development Response To Organic Substance Metabolic Process Cell Differentiation Cellular Response To Organic Substance Regulation Of Cell Differentiation Regulation Of Cell Proliferation Tissue Development Cellular Response To Stress	Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Gene Expression Signaling Cell Communication Signal Transduction Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Multicellular Organismal Development Regulation Of Metabolic Process Response To Stimulus Developmental Process Negative Regulation Of Signaling Wnt Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Signal Transduction System Development Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Development Negative Regulation Of Cellular Metabolic Process Cell Development Regulation Of Wnt Signaling Pathway Regulation Of Cell Differentiation Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Epithelium Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		adulthood amp backgroundrubinstein big births broad consuming cooperation costly disabilities discussionrsts dysmorphic ep300 establishing extremely facial highlighted intellectual microcephaly multicenter retardation rsts summarized summarythe survive taybi thumbs toe toes	acc acquires adrenal adrenocortical altering came centripetal compr cortex detail examining exome gland igf2 landscape medulla mutational opening perspectives physiol played prognostication progress steroidogenic subcapsular summarizes tracing zonation zones
Tagcloud (Difference) ?		adulthood amp backgroundrubinstein big births broad consuming cooperation costly disabilities discussionrsts dysmorphic ep300 establishing extremely facial highlighted intellectual microcephaly multicenter retardation rsts summarized summarythe survive taybi thumbs toe toes	acc acquires adrenal adrenocortical altering came centripetal compr cortex detail examining exome gland igf2 landscape medulla mutational opening perspectives physiol played prognostication progress steroidogenic subcapsular summarizes tracing zonation zones
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