CREB1 and SOX9

Number of citations of the paper that reports this interaction (PMID 19113914)
8

Data Source:
HPRD (in vivo)

		CREB1	SOX9
Gene Name		cAMP responsive element binding protein 1	SRY (sex determining region Y)-box 9
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin ATF1-ATF4 Transcription Factor Complex	Nucleus Nucleoplasm Protein Complex Nuclear Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Enzyme Binding CAMP Response Element Binding	Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Enhancer Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Kinase Activity Protein Binding Beta-catenin Binding Protein Kinase A Catalytic Subunit Binding Enhancer Binding BHLH Transcription Factor Binding Protein Heterodimerization Activity Pre-mRNA Intronic Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Protein Phosphorylation Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Notch Signaling Pathway Synaptic Transmission Axon Guidance Lactation Memory Circadian Rhythm Regulation Of Cell Size Fibroblast Growth Factor Receptor Signaling Pathway Response To Organic Substance Negative Regulation Of Transcription By Competitive Promoter Binding Viral Process Pituitary Gland Development Secretory Granule Organization Response To Glucagon Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Multicellular Organism Growth Response To Drug Innate Immune Response Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Stabilization Stress-activated MAPK Cascade Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion	Skeletal System Development Cartilage Condensation Ossification Branching Involved In Ureteric Bud Morphogenesis Cell Fate Specification Epithelial To Mesenchymal Transition Tissue Homeostasis Positive Regulation Of Protein Phosphorylation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Immune System Process Heart Valve Development Heart Valve Morphogenesis Heart Valve Formation Endocardial Cushion Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Chondrocyte Hypertrophy Nucleosome Assembly Chromatin Remodeling Transcription From RNA Polymerase II Promoter Protein Complex Assembly Protein Phosphorylation Cytoskeleton Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Spermatogenesis Positive Regulation Of Cell Proliferation Male Gonad Development Regulation Of Cell Cycle Process Positive Regulation Of Epithelial Cell Migration Neural Crest Cell Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Single Organismal Cell-cell Adhesion Male Germ-line Sex Determination CAMP-mediated Signaling Regulation Of Cell Adhesion Extracellular Matrix Organization Negative Regulation Of Ossification Negative Regulation Of Bone Mineralization Prostate Gland Development Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Mammary Gland Development Notochord Development Otic Vesicle Formation Endocrine Pancreas Development Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Somatic Stem Cell Maintenance Intrahepatic Bile Duct Development Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Myoblast Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Photoreceptor Cell Differentiation Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Cartilage Development Sertoli Cell Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Limb Bud Formation Retinal Rod Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Intestinal Epithelial Structure Maintenance Regulation Of Cell Proliferation Involved In Tissue Homeostasis Positive Regulation Of Cartilage Development Regulation Of Branching Involved In Lung Morphogenesis Morphogenesis Of A Branching Epithelium Negative Regulation Of Biomineral Tissue Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Interleukin-1 Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Heparin Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Induction Ureter Urothelium Development Ureter Smooth Muscle Cell Differentiation Ureter Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Male Gonad Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Signaling by the B Cell Receptor (BCR) Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras PLCG1 events in ERBB2 signaling NOTCH2 intracellular domain regulates transcription Signaling by SCF-KIT Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Signaling by NOTCH2 PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events CaMK IV-mediated phosphorylation of CREB DAP12 interactions PKA-mediated phosphorylation of CREB GAB1 signalosome Signaling by NOTCH TRIF-mediated TLR3/TLR4 signaling Opioid Signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma CaMK IV-mediated phosphorylation of CREB Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR CREB phosphorylation through the activation of CaMKK AKT phosphorylates targets in the nucleus Calmodulin induced events Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction CREB phosphorylation through the activation of CaMKII Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Transcriptional activation of mitochondrial biogenesis Transmission across Chemical Synapses Adaptive Immune System Organelle biogenesis and maintenance CREB phosphorylation Axon guidance PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation DAG and IP3 signaling Toll Like Receptor TLR6:TLR2 Cascade CaM pathway Activated TLR4 signalling MyD88 cascade initiated on plasma membrane PI3K events in ERBB2 signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Post NMDA receptor activation events Innate Immune System Signalling by NGF PLC beta mediated events MAP kinase activation in TLR cascade Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Mitochondrial biogenesis Signaling by FGFR Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade PLC-gamma1 signalling MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs		Adenosine monophosphate Naloxone
Diseases
GWAS			Bone mineral density ( 22504420) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Pulmonary function (interaction) ( 23284291) Pulmonary function decline ( 22424883) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		75 interactors: ABL1 AKT1 ATF1 ATF6 ATF7IP ATM ATR C14orf1 CAMK2A CCDC6 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 DYRK1A EDF1 EP300 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HNF1B HPS6 KAT5 KCNIP3 KIAA2026 MAPK14 MAPKAPK2 MTF2 MYC NR3C1 PDX1 PIAS1 POGZ POU2F1 PPP1CA PRKACA PRKG1 RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92	14 interactors: ATP6V1H CREB1 CREB3L4 CREBBP EP300 HERC1 HSPA1A KPNB1 MAF MED12 NR5A1 RUNX2 SPEN TRAF2
Entrez ID		1385	6662
HPRD ID		00442	06427
Ensembl ID		ENSG00000118260	ENSG00000125398
Uniprot IDs		P16220 Q53X93 Q5U0J5	P48436
PDB IDs		2LXT	1S9M 1SX9 4EUW
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Peptidyl-serine Phosphorylation Negative Regulation Of Gene Expression Regulation Of Cellular Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance Cellular Response To Stress Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Chromatin Organization Response To Stress Regulation Of Signaling Peptidyl-amino Acid Modification Regulation Of Cellular Response To Heat Organelle Organization Cell Differentiation Transcription From RNA Polymerase II Promoter	Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Viral Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Transcription, DNA-templated Notch Signaling Pathway RNA Metabolic Process RNA Biosynthetic Process Response To Organic Substance Transcription Initiation From RNA Polymerase II Promoter Gene Expression Cellular Response To Organic Substance Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Heat DNA-templated Transcription, Initiation Cellular Response To Stimulus Signal Transduction Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Stabilization Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Signaling Rhythmic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Communication Response To Heat Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Unfolded Protein
Tagcloud ?		aao acting allelic chemokine citrate emerged enrichment exceeded fact fdr fdraao fdrmsss gwas hubs influencing italian leukocyte msss network networks nominally ppms sclerosis severity snps tca trait traits transendothelial	atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish
Tagcloud (Difference) ?		aao acting allelic chemokine citrate emerged enrichment exceeded fact fdr fdraao fdrmsss gwas hubs influencing italian leukocyte msss network networks nominally ppms sclerosis severity snps tca trait traits transendothelial	atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive eya2 fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish
Tagcloud (Intersection) ?