SOCS4 and SPRY1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SOCS4	SPRY1
Gene Name		suppressor of cytokine signaling 4	sprouty homolog 1, antagonist of FGF signaling (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Inhibitor Activity	Protein Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Growth Negative Regulation Of JAK-STAT Cascade	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade
Pathways			Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EGFR MDFIC NR4A1 SPRY1 VWF	27 interactors: ATXN7 CACNA1A CREB5 GEMIN4 GRB2 HEXIM2 HOXA1 HRG KPNA2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 LCE1B LCE2D MDFI MEOX2 NOTCH2NL OTX1 R3HDM2 SOCS4 SPRY2 STAT3 YY1
Entrez ID		122809	10252
HPRD ID		18084	06782
Ensembl ID		ENSG00000180008	ENSG00000164056
Uniprot IDs		Q5H9R6 Q8WXH5	O43609
PDB IDs		2IZV
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Alkanesulfonate Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Phosphatidylinositol-mediated Signaling Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Liver Development Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Protein Import Into Nucleus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Steroid Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Placenta Development Response To Fibroblast Growth Factor Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Activation Of Phospholipase A2 Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Positive Regulation Of Phospholipase A2 Activity Lung Development Respiratory Tube Development Organ Development Response To Cobalamin Response To UV-A Regulation Of Intracellular Protein Transport Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development System Development Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of ERBB Signaling Pathway Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Pattern Specification Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Embryonic Organ Development Regulation Of ERBB Signaling Pathway Regulation Of Phosphorylation Pons Development Anterior/posterior Pattern Specification Inner Ear Morphogenesis Sensory Organ Development Regulation Of Phosphorus Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Embryonic Morphogenesis Ear Morphogenesis Negative Regulation Of Signal Transduction Metencephalon Development Embryo Development Transcription, DNA-templated Negative Regulation Of Signaling Negative Regulation Of Phosphorylation RNA Biosynthetic Process Hindbrain Development RNA Metabolic Process Regulation Of Gene Expression Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Inner Ear Development Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Keratinization Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		abovementioned activators exceptions expressions glucocorticosteroids jak jak1 jak3 jaks leukocytes nephrotic ns socs1 socs2 socs3 socs5 srns ssns stat stat2 stat6 stats steroid steroids suppressors transducers tyk2 unfavorable	adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry2 stam2 transducing ut7epo validating
Tagcloud (Difference) ?		abovementioned activators exceptions expressions glucocorticosteroids jak jak1 jak3 jaks leukocytes nephrotic ns socs1 socs2 socs3 socs5 srns ssns stat stat2 stat6 stats steroid steroids suppressors transducers tyk2 unfavorable	adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry2 stam2 transducing ut7epo validating
Tagcloud (Intersection) ?