CLASRP and DYRK1A

Number of citations of the paper that reports this interaction (PMID 14623875)
20

Data Source:
BioGRID (enzymatic study)

		CLASRP	DYRK1A
Gene Name		CLK4-associating serine/arginine rich protein	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nuclear Speck Ribonucleoprotein Complex
	Molecular Function		Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding
	Biological Process	MRNA Processing RNA Splicing	Mitotic Cell Cycle Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Positive Regulation Of Protein Deacetylation
Pathways			G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			HIV-1 replication ( 21364930) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		10 interactors: APP ATXN1 CDK6 CLK4 DAB1 DAZAP2 DYRK1A RHOXF2 SMAD3 VDR	26 interactors: AMPH APP CCNL2 CLASRP CREB1 FOXO1 GLI1 HIST1H2BB HIST1H3A HIST1H4A LATS2 LIN52 LZTS2 PHYHIP PRD RB1 RBL1 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG
Entrez ID		11129	1859
HPRD ID		11552	09018
Ensembl ID		ENSG00000104859	ENSG00000157540
Uniprot IDs		B4DDT8 Q8N2M8	F8WAP0 Q13627
PDB IDs			2VX3 2WO6 3ANQ 3ANR 4AZE
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Regulation Of Gene Expression Adult Behavior Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Locomotory Behavior Tube Development Negative Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation System Development Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Regulation Of Cell Development Regulation Of RNA Metabolic Process Organ Development Visual Learning Visual Behavior Multicellular Organismal Development Negative Regulation Of Ossification Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Cell Dedifferentiation Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Nitrogen Compound Metabolic Process Associative Learning Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Forebrain Development Single-organism Behavior Negative Regulation Of Signaling Regulation Of RNA Splicing Cell Adhesion Positive Regulation Of Cell Development Positive Regulation Of Protein Metabolic Process Vitamin D Receptor Signaling Pathway Cerebellum Structural Organization Synaptic Growth At Neuromuscular Junction Developmental Process Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Protein Phosphorylation Regulation Of Osteoblast Differentiation Negative Regulation Of Epithelial Cell Proliferation RNA Processing	Gene Expression Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing MRNA 3'-end Processing Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Establishment Of Localization In Cell Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Regulation Of Phosphorylation Cellular Nitrogen Compound Metabolic Process MRNA Processing Negative Regulation Of Gene Expression RNA 3'-end Processing RNA Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nuclear Export Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase II Transcription Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation MRNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process RNA Splicing Response To Growth Factor Positive Regulation Of Mitochondrion Organization Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Cellular Macromolecular Complex Assembly DNA Replication-dependent Nucleosome Assembly Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Biosynthetic Process Apoptotic Process Cell Cycle Negative Regulation Of Wnt Signaling Pathway
Tagcloud ?			abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild
Tagcloud (Difference) ?			abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild
Tagcloud (Intersection) ?