ESM1 and ITGB2

Number of citations of the paper that reports this interaction (PMID 11544294)
15

Data Source:
HPRD (in vivo)

		ESM1	ITGB2
Gene Name		endothelial cell-specific molecule 1	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Plasma Membrane Integrin Complex Cell Surface Membrane Vesicle Integrin AlphaL-beta2 Complex Receptor Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Hepatocyte Growth Factor Receptor Binding Integrin Binding Insulin-like Growth Factor Binding	Glycoprotein Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Angiogenesis Regulation Of Cell Growth Sprouting Angiogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Blood Coagulation Regulation Of Cell Shape Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Endothelial Cell Migration Innate Immune Response Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Activated T Cell Proliferation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System Innate Immune System
Drugs			Simvastatin
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ITGB2	41 interactors: CD14 CD226 CD82 COPS3 COPS5 CYTH1 CYTH2 DAB1 DOK1 ESM1 FCER2 FHL2 FUT4 GNB2L1 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 NOTCH2NL NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RANBP9 RDX SYK TLN1 VNN2
Entrez ID		11082	3689
HPRD ID		03310	02506
Ensembl ID		ENSG00000164283	ENSG00000160255
Uniprot IDs		Q9NQ30	A8MYE6 P05107
PDB IDs			1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Involved In Inflammatory Response Heterotypic Cell-cell Adhesion Cellular Extravasation Activated T Cell Proliferation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Endodermal Cell Differentiation Neutrophil Chemotaxis Neutrophil Migration Receptor Clustering Granulocyte Chemotaxis Regulation Of Nitric Oxide Biosynthetic Process Endoderm Formation Natural Killer Cell Activation Regulation Of Reactive Oxygen Species Biosynthetic Process T Cell Proliferation Endothelial Cell Migration Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Endoderm Development Epithelial Cell Migration Epithelium Migration Leukocyte Chemotaxis Toll-like Receptor Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Proliferation Positive Regulation Of Angiogenesis Formation Of Primary Germ Layer Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Reactive Oxygen Species Metabolic Process Cell Chemotaxis Regulation Of Cell Shape Cell-matrix Adhesion Ameboidal-type Cell Migration Positive Regulation Of Innate Immune Response Gastrulation Cell-substrate Adhesion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Angiogenesis Leukocyte Migration Regulation Of Innate Immune Response T Cell Aggregation T Cell Activation Lymphocyte Aggregation	Blood Coagulation Hemostasis Platelet Activation Cell Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Adhesion Regulation Of Immune System Process Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Signal Transduction Defense Response Signal Transduction Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Glial Cell Apoptotic Process Movement Of Cell Or Subcellular Component Locomotion Regulation Of Signaling Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To External Stimulus Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Immune Response Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Immune System Process Positive Regulation Of Phosphorylation Leukocyte Activation Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of Phospholipase C Activity
Tagcloud ?		1x10 4th came clone cpa cpayang3 effusion femur fn1 humerus immunodeficient intracardiac mandible overexpress passages radiography scapula scintigraphy seeking spc subdiploid submaxillary supraclavicular svil tne tough vertebral yang3 yang3bm	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Difference) ?		1x10 4th came clone cpa cpayang3 effusion femur fn1 humerus immunodeficient intracardiac mandible overexpress passages radiography scapula scintigraphy seeking spc subdiploid submaxillary supraclavicular svil tne tough vertebral yang3 yang3bm	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Intersection) ?