TMED1 and IL1RL1

Number of citations of the paper that reports this interaction (PMID 8621446)
12

Data Source:
HPRD (in vivo)

		TMED1	IL1RL1
Gene Name		transmembrane emp24 protein transport domain containing 1	interleukin 1 receptor-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Region External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Matrix
	Molecular Function	Receptor Binding Protein Binding	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Receptor Signaling Protein Activity Protein Binding
	Biological Process	Signal Transduction Cell-cell Signaling Protein Transport	Negative Regulation Of T-helper 1 Type Immune Response Immune Response Signal Transduction Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-5 Production Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Inflammatory Response Positive Regulation Of Chemokine Secretion
Pathways
Drugs
Diseases
GWAS			Asthma ( 23028483 21804549) Atopic dermatitis ( 23042114) Celiac disease ( 20190752 18311140) Crohn's disease ( 21102463) Eosinophil counts ( 19198610) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		3 interactors: IL1RL1 SEC23B SMAD3	6 interactors: APP CLEC7A IL33 MYD88 TIRAP TMED1
Entrez ID		11018	9173
HPRD ID		05653	03123
Ensembl ID			ENSG00000115602
Uniprot IDs		Q13445	B4E0I3 Q01638
PDB IDs			4KC3
Enriched GO Terms of Interacting Partners?		Interleukin-33-mediated Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta3 Production Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Inflammatory Response Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Regulation Of Extracellular Matrix Assembly Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Primary MiRNA Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Chemokine Secretion Transdifferentiation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Macrophage Activation Regulation Of Cytokine Production Paraxial Mesoderm Morphogenesis Nodal Signaling Pathway Regulation Of Protein Transport Positive Regulation Of Interleukin-5 Production Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Establishment Of Protein Localization Regulation Of Osteoblast Proliferation Embryonic Foregut Morphogenesis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Production Of MiRNAs Involved In Gene Silencing By MiRNA Foregut Morphogenesis Modulation By Virus Of Host Morphology Or Physiology Paraxial Mesoderm Development Regulation Of Catenin Import Into Nucleus Positive Regulation Of Transport Thyroid Gland Development Osteoblast Development Positive Regulation Of Interleukin-1 Beta Production Regulation Of Macrophage Activation Regulation Of Interleukin-5 Production Regulation Of Protein Localization Positive Regulation Of Chondrocyte Differentiation Pericardium Development Positive Regulation Of Phosphatase Activity Positive Regulation Of Positive Chemotaxis Positive Regulation Of Interleukin-1 Production Signal Transduction Involved In Regulation Of Gene Expression Activin Receptor Signaling Pathway	Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Regulation Of Interleukin-6 Production 3'-UTR-mediated MRNA Stabilization Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Immune Response Positive Regulation Of Innate Immune Response MRNA Stabilization Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Protein Metabolic Process Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Signal Transduction Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Posttranscriptional Regulation Of Gene Expression Defense Response Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Toll-like Receptor 4 Signaling Pathway Signaling Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cytokine Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Negative Regulation Of Immunoglobulin Secretion TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway
Tagcloud ?			acetylated basophilic basophils chip clarify coexpression dendritic emsa encodes eosinophils gata gata1 gata2 introduced killer ku812 lad2 lineages mast modulator motifs possess repressed sirna sirnas st2 start th2 transactivated
Tagcloud (Difference) ?			acetylated basophilic basophils chip clarify coexpression dendritic emsa encodes eosinophils gata gata1 gata2 introduced killer ku812 lad2 lineages mast modulator motifs possess repressed sirna sirnas st2 start th2 transactivated
Tagcloud (Intersection) ?