DHRS4 and PEX5

Number of citations of the paper that reports this interaction (PMID 22002062)
8

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		DHRS4	PEX5
Gene Name		dehydrogenase/reductase (SDR family) member 4	peroxisomal biogenesis factor 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Intracellular Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Golgi Apparatus Cytosol Membrane Protein Complex
	Molecular Function	3-keto Sterol Reductase Activity Carbonyl Reductase (NADPH) Activity Receptor Binding Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Alcohol Dehydrogenase [NAD(P)+] Activity	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Protein C-terminus Binding Enzyme Binding Small GTPase Binding Protein N-terminus Binding
	Biological Process	Alcohol Metabolic Process Steroid Metabolic Process Cellular Ketone Metabolic Process Protein Tetramerization Oxidation-reduction Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Membrane Protein Tetramerization Negative Regulation Of Protein Homotetramerization
Pathways		Signaling by Retinoic Acid RA biosynthesis pathway
Drugs		Vitamin A
Diseases
GWAS			IgG glycosylation ( 23382691)
Protein-Protein Interactions		1 interactors: PEX5	68 interactors: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECH1 ECI2 EP400NL EPHX2 FIS1 GDPD5 GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PECR PEX10 PEX12 PEX13 PEX14 PEX7 PIPOX POT1 PRDX5 PRR13 RPL14 S100A6 SCARB1 SCP2 SIRT3 SLC27A2 SNUPN SSTR5 TINF2 TM6SF1 TOMM7 USP9X ZNF772
Entrez ID		10901	5830
HPRD ID		07484	02684
Ensembl ID		ENSG00000157326	ENSG00000139197
Uniprot IDs		Q9BTZ2	B4DR50 B4E0T2 P50542
PDB IDs		3O4R	1FCH 2C0L 2C0M 2J9Q 2W84 3R9A
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Protein Homooligomerization Protein Import Into Peroxisome Membrane Protein To Membrane Docking Peroxisomal Membrane Transport Negative Regulation Of Protein Oligomerization Protein Import Into Peroxisome Matrix Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Very Long-chain Fatty Acid Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Endoplasmic Reticulum Organization Fatty Acid Beta-oxidation Peroxisome Organization Positive Regulation Of Multicellular Organism Growth Intracellular Protein Transmembrane Transport Mitochondrial Membrane Organization Protein Transmembrane Transport Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Cerebral Cortex Cell Migration Membrane Docking Regulation Of Multicellular Organism Growth Telencephalon Cell Migration Forebrain Cell Migration Protein Tetramerization Neuromuscular Process Negative Regulation Of Protein Complex Assembly Cellular Lipid Catabolic Process Positive Regulation Of Developmental Growth Cerebral Cortex Development Protein Import Protein Targeting To Membrane Neuron Migration Lipid Modification Carboxylic Acid Catabolic Process Pallium Development Central Nervous System Neuron Differentiation Positive Regulation Of Growth Establishment Of Protein Localization To Membrane Lipid Catabolic Process Telencephalon Development Regulation Of Developmental Growth Fatty Acid Metabolic Process Regulation Of Protein Complex Assembly Establishment Of Protein Localization To Organelle	Carboxylic Acid Catabolic Process Monocarboxylic Acid Metabolic Process Fatty Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Fatty Acid Oxidation Catabolic Process Lipid Oxidation Fatty Acid Catabolic Process Lipid Metabolic Process Cellular Lipid Metabolic Process Lipid Modification Cellular Lipid Catabolic Process Lipid Catabolic Process Peroxisome Organization Oxidation-reduction Process Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Protein Import Into Peroxisome Matrix Cellular Metabolic Process Acyl-CoA Metabolic Process Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Bile Acid Biosynthetic Process Intracellular Protein Transmembrane Transport Cofactor Metabolic Process Protein Transmembrane Transport Lipid Biosynthetic Process Bile Acid Metabolic Process Fatty Acid Alpha-oxidation Sulfur Compound Metabolic Process Glyoxylate Metabolic Process Protein Import Protein Localization To Organelle Establishment Of Protein Localization To Organelle Steroid Biosynthetic Process Protein Targeting Telomere Assembly Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Steroid Metabolic Process Cellular Amino Acid Catabolic Process Long-chain Fatty Acid Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Cellular Process Dicarboxylic Acid Catabolic Process Coenzyme A Catabolic Process
Tagcloud ?		antisense cluster deacetylation demethylation discriminative duplicated duplication encodes g9a h3k27 h3k4 h3k9 h3k9me2 head methyltransferases modifiers nat nats noncoding overlapped pairing physically recruiting scanty sense tight	behave behaves cargo cooperatively couple cytosol deubiquitination differently disuse energetics folded identically import importers importomer lumen organelles peroxisomal peroxisome peroxisomes pexophagy shuttle stochastic traffic translationally translocated translocation ubiquitin uncoupled
Tagcloud (Difference) ?		antisense cluster deacetylation demethylation discriminative duplicated duplication encodes g9a h3k27 h3k4 h3k9 h3k9me2 head methyltransferases modifiers nat nats noncoding overlapped pairing physically recruiting scanty sense tight	behave behaves cargo cooperatively couple cytosol deubiquitination differently disuse energetics folded identically import importers importomer lumen organelles peroxisomal peroxisome peroxisomes pexophagy shuttle stochastic traffic translationally translocated translocation ubiquitin uncoupled
Tagcloud (Intersection) ?