CCT2 and FCHSD2

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		CCT2	FCHSD2
Gene Name		chaperonin containing TCP1, subunit 2 (beta)	FCH and double SH3 domains 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Unfolded Protein Binding	Protein Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Chaperone-mediated Protein Complex Assembly Toxin Transport
Pathways		Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS		Height ( 18391951)	Crohn's disease ( 23266558)
Protein-Protein Interactions		18 interactors: ACTA1 ACTB EEF2 ERLIN2 FCHSD2 HSP90AB1 HSP90B1 PRPF40A PSMC6 PSMD2 RPS3 SSSCA1 SUMO4 TUBA1B TUBB VAV2 VRK2 YWHAG	25 interactors: ABCF3 C2orf73 C9orf78 CASK CCDC158 CCDC85B CCT2 CFAP36 CHKA DAPP1 FAM9B HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 MSL1 MTUS2 PDE4DIP SH3BGR SRP72 VCPIP1 WAS WASL
Entrez ID		10576	9873
HPRD ID		06895	13321
Ensembl ID		ENSG00000166226	ENSG00000137478
Uniprot IDs		P78371	E9PG19 O94868
PDB IDs			2DL5 2DL7
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Division Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cellular Protein Metabolic Process Cell Cycle Phase Transition Positive Regulation Of Transferase Activity Regulation Of Apoptotic Process Protein Folding Immune System Process Regulation Of Cell Death Cell Cycle Process Endocytosis Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Innate Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stress Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Immune Response-regulating Signaling Pathway Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Modification-dependent Protein Catabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Stress Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Catalytic Activity Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Programmed Cell Death Response To Interleukin-4 Cellular Protein Catabolic Process Cell Death Death Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of DNA N-glycosylase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint 'de Novo' Posttranslational Protein Folding Protein Catabolic Process Phagocytosis	Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Arp2/3 Complex-mediated Actin Nucleation Endocytosis Regulation Of Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Toxin Transport Cellular Response To Interleukin-4 Vesicle-mediated Transport Response To Interleukin-4 Regulation Of Protein Folding In Endoplasmic Reticulum Protein Complex Assembly Phagocytosis Actin Filament-based Movement Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Golgi Organization Endoplasmic Reticulum Membrane Fusion Negative Regulation Of Membrane Tubulation Cerebellum Structural Organization Transport Actin Polymerization Or Depolymerization Cellular Protein Complex Assembly Zonula Adherens Maintenance Vesicle Transport Along Actin Filament Cellular Component Assembly Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Golgi Reassembly Dentinogenesis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Axon Guidance Protein Localization To Endoplasmic Reticulum Positive Regulation Of Clathrin-mediated Endocytosis Movement Of Cell Or Subcellular Component Response To Unfolded Protein Immune Response-regulating Signaling Pathway Choline Metabolic Process Golgi Inheritance Protein K11-linked Deubiquitination
Tagcloud ?		antral atresia atretic bga build categorized cattle cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis tgm2 transcriptomic ultimately
Tagcloud (Difference) ?		antral atresia atretic bga build categorized cattle cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis tgm2 transcriptomic ultimately
Tagcloud (Intersection) ?