PRDX4 and DUSP23

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PRDX4	DUSP23
Gene Name		peroxiredoxin 4	dual specificity phosphatase 23
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Mitochondrion Smooth Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome	Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity Protein Homodimerization Activity	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	I-kappaB Phosphorylation Spermatogenesis Male Gonad Development 4-hydroxyproline Metabolic Process Protein Maturation By Protein Folding Extracellular Matrix Organization Cell Redox Homeostasis Oxidation-reduction Process Reactive Oxygen Species Metabolic Process Negative Regulation Of Male Germ Cell Proliferation	Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs
Diseases
GWAS			C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)
Protein-Protein Interactions		24 interactors: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 COX1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 VTN	24 interactors: ASB13 CCDC186 DBI DBN1 DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 KIAA1377 MKRN1 MRPL20 MTFR1 NIF3L1 PRDX4 RPL8 RUFY2 SHC1 SMPD1 TMOD3 TUBA1A ZNF746
Entrez ID		10549	54935
HPRD ID		05935	07908
Ensembl ID		ENSG00000123131	ENSG00000158716
Uniprot IDs		Q13162	Q9BVJ7
PDB IDs		2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS	2IMG 4ERC
Enriched GO Terms of Interacting Partners?		Hydrogen Peroxide Catabolic Process Cellular Response To Reactive Oxygen Species Response To Stress Hydrogen Peroxide Metabolic Process Immune System Process Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Response To Oxidative Stress Response To Inorganic Substance Catabolic Process Reactive Oxygen Species Metabolic Process Defense Response Removal Of Superoxide Radicals Response To Lipopolysaccharide Cellular Response To Superoxide Response To Molecule Of Bacterial Origin Xenobiotic Metabolic Process Negative Regulation Of Proteolysis Cellular Response To Xenobiotic Stimulus Response To Superoxide Response To Oxygen Radical Regulation Of Proteolysis Response To Xenobiotic Stimulus Negative Regulation Of Protein Processing Regulation Of Mitochondrial Membrane Potential Regulation Of Protein Processing Response To Stimulus Bile Acid Metabolic Process Blood Coagulation Hemostasis Superoxide Metabolic Process Platelet Activation Innate Immune Response Cell Migration Positive Regulation Of Wound Healing Response To Lipid Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Thromboxane A2 Signaling Pathway Hsp90 Deacetylation Immune Response Response To Bacterium Carbohydrate Derivative Transport Leukocyte Migration Negative Regulation Of Blood Coagulation Cell Motility Negative Regulation Of Coagulation Steroid Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels	Cellular Metabolic Process Organelle Organization Regulation Of Gene Expression By Genetic Imprinting Gene Expression Genetic Imprinting Positive Regulation Of Histone Methylation Negative Regulation Of Male Germ Cell Proliferation Regulation Of Histone Methylation Positive Regulation Of Protein Modification Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Positive Regulation Of Histone Modification Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Regulation Of Male Germ Cell Proliferation Dihydrobiopterin Metabolic Process Cell Communication By Chemical Coupling S-adenosylmethioninamine Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization
Tagcloud ?		1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize
Tagcloud (Difference) ?		1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize
Tagcloud (Intersection) ?