CEBPA and RARA

Number of citations of the paper that reports this interaction (PMID 23898169)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CEBPA	RARA
Gene Name		CCAAT/enhancer binding protein (C/EBP), alpha	retinoic acid receptor, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Matrix Rb-E2F Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cell Surface Actin Cytoskeleton Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Complex Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding	Translation Repressor Activity, Nucleic Acid Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Retinoic Acid Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Transcription Coactivator Activity Transcription Corepressor Activity Receptor Binding Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Chromatin DNA Binding Phosphatidylinositol 3-kinase Regulator Activity Protein Kinase B Binding Retinoic Acid-responsive Element Binding Protein Heterodimerization Activity MRNA 5'-UTR Binding Protein Kinase A Binding Alpha-actinin Binding
	Biological Process	Urea Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Embryonic Placenta Development Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Acute-phase Response Mitochondrion Organization Cholesterol Metabolic Process Negative Regulation Of Cell Proliferation Viral Process Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Macrophage Differentiation Lung Development Organ Regeneration Response To Vitamin B2 Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Cell Maturation Inner Ear Development White Fat Cell Differentiation Brown Fat Cell Differentiation Response To Glucocorticoid Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Neural Tube Closure Liver Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Germ Cell Development Spermatogenesis Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Intracellular Estrogen Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Granulocyte Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Response To Estradiol Response To Retinoic Acid Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Response To Vitamin A Response To Cytokine Multicellular Organism Growth Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Steroid Hormone Mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Response To Ethanol Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Binding Positive Regulation Of Protein Kinase B Signaling Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport Sertoli Cell Fate Commitment Limb Development Face Development Trachea Cartilage Development Chondroblast Differentiation Negative Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Estrogen Stimulus
Pathways		Transcriptional regulation of white adipocyte differentiation	Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs			Adapalene Acitretin Alitretinoin Tazarotene Etretinate Isotretinoin Tamibarotene
Diseases
GWAS
Protein-Protein Interactions		56 interactors: AR ATF2 ATF3 ATF4 ATF5 BATF BATF2 BATF3 C1QBP CDK2 CDK4 CDKN1A CDKN3 CDX1 CEBPB CEBPD CEBPE CEBPG CREBBP CTNNB1 DBP EDF1 EP300 ESR1 FOS FOSL1 GATA2 GSK3B HNF1A MAPK8 MSX2 MYC NCOA6 NFYA NR3C1 PIAS1 RARA RARB RASGRF1 RB1 RBL1 RFC1 RUNX1 SKP2 SMAD3 SMAD4 SMARCA2 SMARCA4 SOX10 SOX8 SPI1 SRA1 SUMO3 XRCC5 XRCC6 ZBTB16	86 interactors: AKT1 ARID1A ARID5A ARNTL BAG1 BTG1 CCND3 CDK7 CEBPA CLOCK CNOT1 COPS2 E2F1 ESR1 FN1 FOXO1 GADD45G GATA2 HDAC1 HDAC3 HDAC4 HMGA1 HR IRX4 ITGB1BP2 KAT2B KDM5A KLF5 LRIF1 MAPK6 MECR MED1 MED25 MED6 MMS19 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR2E3 NR3C1 NR4A2 NRBF2 NRIP1 NRIP2 NSD1 PARP1 PHF8 PIN1 PML PNRC2 POU2F1 PRAME PRDX6 PRKCA PSMC5 RAC3 RXRA RXRB RXRG SIRT1 SMARCD3 SMARCE1 SNW1 SP1 SPEN SRC STAT5B TADA3 TEKT4 THRB TNIP1 TOP2B TRIM24 TRIP4 UBE3A UBQLN1 USP7 ZBTB16
Entrez ID		1050	5914
HPRD ID		00296	06769
Ensembl ID		ENSG00000245848
Uniprot IDs		P49715	A8K840 A8MUP8 B4E1J4 F1D8N9 P10276 Q6I9R7
PDB IDs			1DKF 1DSZ 3A9E 3KMR 3KMZ 4DQM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated System Development Multicellular Organismal Development Cellular Metabolic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Cell Differentiation Regulation Of Cell Proliferation Regulation Of Cell Differentiation Tissue Development Myeloid Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Death Transcription Initiation From RNA Polymerase II Promoter	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Biosynthetic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Multicellular Organismal Development Rhythmic Process Developmental Process Cellular Response To Hormone Stimulus System Development Cellular Response To Organic Substance Organ Development Chromatin Modification
Tagcloud ?		acting additive c38 c40 caat cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent pou pou3f1 redundant repress robust	apl bodies compartmentalisation covalently dependant disrupted fits indirectly kr leukaemia localisation localises lys487 lys490 modification modifies mutagenesis named nd10 phosphoprotein pic1 pml pods promyelocytic rangap1 subcellular sumo translocated ubc9
Tagcloud (Difference) ?		acting additive c38 c40 caat cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent pou pou3f1 redundant repress robust	apl bodies compartmentalisation covalently dependant disrupted fits indirectly kr leukaemia localisation localises lys487 lys490 modification modifies mutagenesis named nd10 phosphoprotein pic1 pml pods promyelocytic rangap1 subcellular sumo translocated ubc9
Tagcloud (Intersection) ?