NCOA2 and DLX2

Number of citations of the paper that reports this interaction (PMID 11675124)
7

Data Source:
HPRD (in vivo, two hybrid)

		NCOA2	DLX2
Gene Name		nuclear receptor coactivator 2	distal-less homeobox 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Thyroid Hormone Receptor Coactivator Activity Nuclear Hormone Receptor Binding Protein Dimerization Activity	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Single-stranded RNA Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Glucose Metabolic Process Histone Acetylation Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Circadian Regulation Of Gene Expression Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Receptor Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Brain Development Proximal/distal Pattern Formation Subpallium Development Hippocampus Development Olfactory Bulb Development Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment Cerebral Cortex GABAergic Interneuron Fate Commitment Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Cranial Skeleton Morphogenesis Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of A Nerve Cartilage Development
Pathways		PPARA activates gene expression Bile acid and bile salt metabolism Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Generic Transcription Pathway Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Transcriptional regulation of white adipocyte differentiation Biological oxidations Synthesis of bile acids and bile salts Orphan transporters Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Recycling of bile acids and salts Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) REV-ERBA represses gene expression Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Mitochondrial biogenesis Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Non-small cell lung cancer ( 23144319)	Breast cancer ( 23535729)
Protein-Protein Interactions		63 interactors: ACTN2 AHR ANKRD11 AR ARNT BRCA1 CARM1 CCND3 CCNT1 CDK4 CREBBP CTNNB1 DDX17 DDX5 DLX2 DLX5 EID1 EP300 ESR1 ESR2 ESRRB ETV1 FOS GMEB1 HIF1A HIST3H3 HIST4H4 HNF4A JUN KIF5A KIF5B KIF5C MAGEA11 MEF2C NKX2-1 NR1I2 NR3C1 NR4A1 OPN1LW PIAS3 PML PPARA PPARD PPARG PPFIA1 PPFIA4 PRMT1 PSMB9 RARA RORA RXRA SLC30A9 SMARCE1 SRA1 SRCAP STAT6 SUMO1 TAF9 THRB TP53 TXNRD2 VDR YWHAH	14 interactors: AVP BZRAP1 DGCR6 DIP2A DLX5 GRN HOXC8 MSX1 MSX2 MVP NCOA2 PARK2 PIK3R1 XRCC6
Entrez ID		10499	1746
HPRD ID		09066	00527
Ensembl ID		ENSG00000140396	ENSG00000115844
Uniprot IDs		Q15596	Q07687 Q53QU7
PDB IDs		1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3Q97 3R5M 3UP0 3UP3 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Steroid Hormone Mediated Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression DNA-templated Transcription, Initiation Gene Expression Hormone-mediated Signaling Pathway Positive Regulation Of Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Response To Steroid Hormone Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription, DNA-templated Response To Organic Cyclic Compound Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Response To Hormone Response To Lipid Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Organic Substance Anatomical Structure Development Developmental Process Multicellular Organismal Development Biosynthetic Process Cellular Response To Hormone Stimulus Cellular Response To Organic Substance	Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Activation Of Meiosis Regulation Of Transcription From RNA Polymerase II Promoter BMP Signaling Pathway Involved In Heart Development Negative Regulation Of Cellular Metabolic Process Nail Development Positive Regulation Of Gene Expression BMP Signaling Pathway Hyperosmotic Salinity Response Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Morphogenesis Regulation Of DNA Binding Protein Stabilization Negative Regulation Of Transcription Regulatory Region DNA Binding Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Multicellular Organismal Development Bone Morphogenesis Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Release Of Cytochrome C From Mitochondria Endocardial Cushion Formation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Stability Hyperosmotic Response Endocardial Cushion Morphogenesis Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Apoptotic Process Embryonic Limb Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Transcription, DNA-templated Limb Morphogenesis Developmental Process Negative Regulation Of Cell Death Negative Regulation Of Mitochondrion Organization RNA Biosynthetic Process Organ Morphogenesis Signal Transduction Involved In Regulation Of Gene Expression Signaling Limb Development Face Morphogenesis
Tagcloud ?		bioenergy causally clearer clinicopathologies colonize coregulator coregulators decidual decidualization decidualize dovetailing endometriotic evade glycolytic launch minireview ncoa1 ncoa3 p160 pacemaker pathobiology pleiotropy proposal quiescence subfecundity tantalizing triad underexplored underpinning	acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx5 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby
Tagcloud (Difference) ?		bioenergy causally clearer clinicopathologies colonize coregulator coregulators decidual decidualization decidualize dovetailing endometriotic evade glycolytic launch minireview ncoa1 ncoa3 p160 pacemaker pathobiology pleiotropy proposal quiescence subfecundity tantalizing triad underexplored underpinning	acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx5 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby
Tagcloud (Intersection) ?