CDKN2A and EGR1

Number of citations of the paper that reports this interaction (PMID 19057511)
27

Data Source:
HPRD (in vitro)

		CDKN2A	EGR1
Gene Name		cyclin-dependent kinase inhibitor 2A	early growth response 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Nuclear Body Senescence-associated Heterochromatin Focus Protein Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	P53 Binding DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Poly(A) RNA Binding NF-kappaB Binding Ubiquitin-protein Transferase Inhibitor Activity MDM2/MDM4 Family Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Negative Regulation Of Cell-matrix Adhesion Transcription, DNA-templated RRNA Processing Negative Regulation Of Protein Kinase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Arrest Ras Protein Signal Transduction Negative Regulation Of Cell Proliferation Apoptotic Mitochondrial Changes Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Growth Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Protein Sumoylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Export From Nucleus Somatic Stem Cell Division Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of Cell Cycle Arrest Cellular Senescence Replicative Senescence Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cellular Senescence	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Amphetamine Transcription From RNA Polymerase II Promoter Learning Or Memory Circadian Rhythm Response To Glucose Cytokine-mediated Signaling Pathway T Cell Differentiation BMP Signaling Pathway Response To Nutrient Levels Cellular Response To Insulin Stimulus Regulation Of Protein Sumoylation Response To Carbon Monoxide Cellular Response To Drug Skeletal Muscle Cell Differentiation Response To Cocaine Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Long-term Neuronal Synaptic Plasticity Oligodendrocyte Differentiation Response To Electrical Stimulus Long-term Synaptic Potentiation Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Antibiotic Cellular Response To Mechanical Stimulus Cellular Response To Isoquinoline Alkaloid Cellular Response To CAMP Cellular Response To Growth Factor Stimulus Cellular Response To Gonadotropin Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Hyperoxia Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To Heparin Cellular Response To Mycophenolic Acid Response To Norepinephrine Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic Oxidative Stress Induced Senescence Cellular Senescence Oncogene Induced Senescence	Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 20622881) Breast cancer ( 23535729 20453838) Coronary artery calcification ( 23561647) Coronary heart disease ( 21626137 21971053 17554300 21378990) Endometriosis ( 23104006) Glioma ( 21531791 19578367) Intracranial aneurysm ( 18997786 20364137) Melanoma ( 21983787 19578364) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Platelet counts ( 22139419) Type 2 diabetes ( 21573907 18372903 20581827 19401414 17463246 17463248 17463249 23209189)
Protein-Protein Interactions		94 interactors: ACLY ACTB ACTG1 ACTN4 AHNAK ANKRD12 ARFIP2 BCL2L1 BECN1 CARF CCDC183 CCND1 CCND2 CCNG1 CDC45 CDC5L CDC6 CDC7 CDK4 CDK6 CDKN2AIP CDKN2C CRELD2 CTBP2 DEAF1 E2F1 E4F1 EEF2 EGR1 EPHA3 FN1 GAPDH GGA1 GGA3 GMNN GSPT1 HIF1A HIST3H2BB HNRNPA2B1 HNRNPC HNRNPU HSP90AA1 HSP90AB1 HSPA4 HSPA8 HUWE1 KAT5 MAPK10 MAPK8 MCM10 MCM2 MCM5 MCM6 MDM2 MMRN1 MTR MYC MYL12A NCL NMI ORC4 PCNA PDCD6 PEX19 PLEKHA8 PPP1R9B PRKCA PSMC3 RIN2 RPS7 RUVBL2 SERTAD1 SIVA1 SLC4A1 SMARCA4 SNRPA SNRPB TBRG1 TDRD7 TP63 TPI1 TRIP12 TUBA1A TUBA1C TUBB TUBB4B UBE2A UBE4B USP26 WRN YY1 ZFP91 ZNF227 ZNF410	20 interactors: CDKN2A CEBPB CREBBP CSNK2A1 EP300 ERBB3 IL1B JUN NAB1 NAB2 NFATC1 NFATC2 PITX1 PSMA3 RELA SP1 SRA1 SREBF2 TP53 WT1
Entrez ID		1029	1958
HPRD ID		02542	00549
Ensembl ID		ENSG00000147889	ENSG00000120738
Uniprot IDs		G3XAG3 K7PML8 P42771 Q8N726	P18146 Q546S1
PDB IDs		1A5E 1BI7 1DC2 2A5E
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle G1/S Transition Of Mitotic Cell Cycle Response To Stress Cellular Response To Stress Regulation Of Metabolic Process Regulation Of Cell Cycle Response To Abiotic Stimulus Cellular Response To DNA Damage Stimulus Response To Radiation Negative Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Mitotic Cell Cycle Cell Division Cellular Nitrogen Compound Metabolic Process Response To UV Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication DNA Replication Initiation Nitrogen Compound Metabolic Process Chromosome Organization Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process DNA Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Radiation Regulation Of Protein Metabolic Process DNA-dependent DNA Replication Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Proliferation Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Stimulus DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation	Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Process Cell Differentiation Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Developmental Process Negative Regulation Of Apoptotic Process Immune System Process Negative Regulation Of Programmed Cell Death Immune Response Negative Regulation Of Cell Death Cellular Metabolic Process Positive Regulation By Host Of Viral Transcription Anatomical Structure Morphogenesis
Tagcloud ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	acidic acts astrocyte astrocytes astrocytosis capable cascade controlling decreases exhibits fibrillary gfap glial hiv immunodeficiency importantly indirect nervous neurological neurotoxicity pathogenic roles sequential stat3 tat transactivation transducer upstream
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	acidic acts astrocyte astrocytes astrocytosis capable cascade controlling decreases exhibits fibrillary gfap glial hiv immunodeficiency importantly indirect nervous neurological neurotoxicity pathogenic roles sequential stat3 tat transactivation transducer upstream
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