STUB1 and BAG5

Number of citations of the paper that reports this interaction (PMID 21358815)
18

Data Source:
BioGRID (pull down, affinity chromatography technology)

		STUB1	BAG5
Gene Name		STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	BCL2-associated athanogene 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Nucleus Mitochondrion Membrane Inclusion Body Perinuclear Region Of Cytoplasm
	Molecular Function	G-protein Coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein Binding, Bridging TPR Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Chaperone Binding
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly	Protein Folding Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Refolding Neuron Death Regulation Of Inclusion Body Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by ERBB2 Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		92 interactors: ABL1 ACD AHR AR ATCAY ATXN3 BAG1 BAG5 BCR BMPR1B CCL28 CTBP2 CYP2E1 CYP3A4 DAXX DNAJB1 DYX1C1 EIF5A ERBB2 ERN1 ESR1 FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A2 GUCY1A3 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 IRF1 JOSD1 JOSD2 KHDRBS1 KIAA1524 MAP3K11 MAP3K2 MAPT MCF2 MITF MPP1 MST1R MYOCD NOS1 NQO1 OLFM3 PARK2 PFN1 POLB POT1 PRKCZ PSMA3 PSMD4 RAF1 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SRC TAL1 TERF1 TGFBR1 TINF2 TRAF6 TXN2 UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2W VCP XIAP	12 interactors: BANP CCDC155 CIRBP FAM118B HSPA4 LRRK2 MAD1L1 PARK2 SNCA STUB1 THAP1 TRIM27
Entrez ID		10273	9529
HPRD ID		06232	04862
Ensembl ID		ENSG00000103266	ENSG00000166170
Uniprot IDs		Q9UNE7	Q9UL15
PDB IDs			2D9D 3A8Y
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Cellular Response To Stimulus Protein Polyubiquitination Response To Stress Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Response To Stimulus Cellular Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Gene Expression Cellular Response To Stress Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cell Death Protein Ubiquitination Response To Growth Factor Regulation Of Cellular Component Organization Protein Modification By Small Protein Conjugation Cellular Protein Metabolic Process Regulation Of Cellular Process Cell Communication Positive Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Regulation Of Apoptotic Process Regulation Of Immune System Process Signaling Cell Death Death Cellular Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Protein Metabolic Process	Negative Regulation Of Protein Metabolic Process Cellular Response To Catecholamine Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Protein Catabolic Process Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Organelle Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Synaptic Vesicle Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Oxidative Stress Cellular Response To Manganese Ion Regulation Of Neurotransmitter Secretion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Mitochondrion Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Negative Regulation Of Protein Phosphorylation Response To Ammonium Ion Dopamine Transport Regulation Of Mitochondrial Fission Neurotransmitter Uptake Synaptic Transmission, Dopaminergic Response To Stress Mitochondrion Organization Negative Regulation Of Transport Negative Regulation Of Phosphorylation Cellular Response To Metal Ion Cellular Localization Response To Unfolded Protein Positive Regulation Of Protein Ubiquitination Regulation Of Organelle Organization Response To Manganese Ion Cellular Response To Inorganic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Dopamine Secretion Cellular Response To Ammonium Ion Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Secretion By Cell Regulation Of Cellular Localization Protein Polyubiquitination Negative Regulation Of Oxidoreductase Activity Protein Localization To Organelle Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Monoamine Transport Negative Regulation Of Secretion
Tagcloud ?		atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike	athanogene compacta decreasing familial interacted mitochondria mptp nigra null park6 parkinson parkinsonism pars pink1 predominantly preventing proteasome pten pull rescued rotenone snpc sporadic stabilize stabilized substantia ubiquitination ups
Tagcloud (Difference) ?		atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike	athanogene compacta decreasing familial interacted mitochondria mptp nigra null park6 parkinson parkinsonism pars pink1 predominantly preventing proteasome pten pull rescued rotenone snpc sporadic stabilize stabilized substantia ubiquitination ups
Tagcloud (Intersection) ?