CDKN1B and IRF1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDKN1B	IRF1
Gene Name		cyclin-dependent kinase inhibitor 1B (p27, Kip1)	interferon regulatory factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Phosphatase Binding Hsp70 Protein Binding Protein Complex Binding Chaperone Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Response To Hypoxia Potassium Ion Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Positive Regulation Of Cell Death Negative Regulation Of Cell Growth Positive Regulation Of Microtubule Polymerization Response To Estradiol Negative Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Phosphorylation Response To Drug Negative Regulation Of Apoptotic Process Response To Amino Acid Response To Peptide Hormone Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Response To Cadmium Ion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Autophagic Cell Death Inner Ear Development Negative Regulation Of Cellular Component Movement Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound Mitotic Cell Cycle Arrest	Regulation Of Adaptive Immune Response Transcription From RNA Polymerase II Promoter Apoptotic Process Cell Cycle Arrest Blood Coagulation Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Interferon-beta CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Regulation Of Cell Cycle Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Mechanical Stimulus Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Cellular Senescence p53-Dependent G1/S DNA damage checkpoint Cyclin E associated events during G1/S transition AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade G1/S Transition Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Signaling by PDGF DAP12 interactions DNA Damage/Telomere Stress Induced Senescence GAB1 signalosome Senescence-Associated Secretory Phenotype (SASP) S Phase Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR SCF(Skp2)-mediated degradation of p27/p21 Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 PI3K/AKT Signaling in Cancer Adaptive Immune System PIP3 activates AKT signaling Orc1 removal from chromatin p53-Dependent G1 DNA Damage Response PI3K events in ERBB2 signaling Downstream signaling of activated FGFR G1/S DNA Damage Checkpoints Innate Immune System Signalling by NGF Synthesis of DNA G1 Phase Regulation of DNA replication Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Cell Cycle, Mitotic Signaling by FGFR Orc1 removal from chromatin Cyclin D associated events in G1 Cell Cycle Checkpoints	Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 23273568)	C-reactive protein ( 21300955) Crohn's disease ( 21102463) Fibrinogen ( 20031576 20031577) Inflammatory bowel disease ( 23128233) Platelet counts ( 22139419)
Protein-Protein Interactions		62 interactors: ABL1 AKT1 ARHGDIA CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE2 CDC34 CDK2 CDK3 CDK4 CDK5 CKS1B COPS5 CUL1 CUL4A GRB2 HIST1H1A HIST1H1B IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 NUP50 PIN1 PSMB1 RCHY1 RNF123 RPS6KA1 SGK1 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE3A UCHL1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	23 interactors: CDKN1B CREBBP EP300 HMGA1 IRF2 IRF8 IRF9 KAT2A KAT2B KEAP1 MDM2 NFKB1 NPM1 QARS RELA SET SPI1 STAT1 STUB1 TRAF3 TRIM28 UBC YBX1
Entrez ID		1027	3659
HPRD ID		02867	00961
Ensembl ID		ENSG00000111276	ENSG00000125347
Uniprot IDs		P46527 Q6I9V6	P10914 Q6FHN8
PDB IDs		1H27 1JSU 2AST
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Response To Organic Substance Cell Communication Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Transferase Activity Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cellular Process Cellular Protein Modification Process Regulation Of Metabolic Process Signal Transduction Positive Regulation Of Cell Cycle Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stimulus Protein Catabolic Process Apoptotic Process Regulation Of Intracellular Transport Programmed Cell Death Viral Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Localization Cell Death Death Positive Regulation Of Intracellular Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Organelle Organization	Negative Regulation Of Gene Expression Innate Immune Response Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Immune Response Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Defense Response Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Macromolecule Biosynthetic Process Cellular Response To Cytokine Stimulus Immune System Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Response To Stress Response To Cytokine Regulation Of Type I Interferon Production N-terminal Peptidyl-lysine Acetylation Regulation Of Protein Metabolic Process Peptidyl-lysine Modification Negative Regulation Of Protein Metabolic Process Biosynthetic Process
Tagcloud ?		aggregated anaplastic atc braf cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e	activating activators architectural assembled assembly atf2 cbp coactivator consisting context decreases deletion designated domains enhanceosome generated hmg jun kappa p65 phenomenon rearrangement recruitment requires substitution sum synergy transcriptional y
Tagcloud (Difference) ?		aggregated anaplastic atc braf cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e	activating activators architectural assembled assembly atf2 cbp coactivator consisting context decreases deletion designated domains enhanceosome generated hmg jun kappa p65 phenomenon rearrangement recruitment requires substitution sum synergy transcriptional y
Tagcloud (Intersection) ?