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SF3B4 and MAPK9
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid, two hybrid)
HPRD
(two hybrid)
SF3B4
MAPK9
Gene Name
splicing factor 3b, subunit 4, 49kDa
mitogen-activated protein kinase 9
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Spliceosomal Complex
U12-type Spliceosomal Complex
Nucleoplasm
Mitochondrion
Cytosol
Molecular Function
Nucleotide Binding
Protein Binding
Poly(A) RNA Binding
JUN Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Mitogen-activated Protein Kinase Kinase Kinase Binding
Biological Process
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
MRNA Processing
RNA Splicing
Gene Expression
Positive Regulation Of MRNA Splicing, Via Spliceosome
Release Of Cytochrome C From Mitochondria
Positive Regulation Of Protein Phosphorylation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Protein Targeting To Mitochondrion
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Stress
JNK Cascade
JUN Phosphorylation
Central Nervous System Development
Response To Mechanical Stimulus
Response To Toxic Substance
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Response To Amine
Neuron Projection Development
Positive Regulation Of Prostaglandin Biosynthetic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Prostaglandin Secretion
Positive Regulation Of Chemokine Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cellular Response To UV
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Response To Drug
Regulation Of Circadian Rhythm
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of JNK Cascade
Response To Cadmium Ion
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Stress-activated MAPK Cascade
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Minor Pathway
mRNA Splicing - Major Pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Activated TLR4 signalling
Toll Like Receptor TLR1:TLR2 Cascade
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Innate Immune System
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Oxidative Stress Induced Senescence
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Drugs
Diseases
GWAS
Height (
20881960
18391951
)
Protein-Protein Interactions
42 interactors:
APBB1
BAG3
BAIAP2
BMPR1A
CHERP
CWF19L2
DDX17
DDX42
EFTUD2
EWSR1
FKBP1A
FRK
GRB2
HNRNPD
HNRNPF
HNRNPH1
HNRNPUL1
HSPB7
ILF3
ITSN1
MAPK9
METTL17
NCK2
NUB1
PPP1R16B
PRPF40A
RBM39
RBM4
SEC24D
SF1
SF3B2
SRSF6
SS18L1
STK19
SUMO4
TCAF1
TCERG1
UBASH3A
UBC
WBP4
WDR77
ZCCHC10
70 interactors:
ACP5
ARRB1
ARRB2
ATF2
ATF7
BAZ1B
BCL2L11
C1orf94
CASP3
CCDC33
CDC25B
CDC25C
CEP44
CLU
CTBP1
CTNNB1
CYHR1
DUSP16
DUSP19
DUSP4
EEF2K
EFHC2
ELK1
ELK3
GRB2
H3F3A
HDAC9
HSF1
IRS1
JDP2
JUN
JUNB
JUND
KIAA1377
L3MBTL3
LMAN2
LNX1
MACF1
MAP2K4
MAP2K7
MAP3K1
MAP3K10
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAPK5
MAPKBP1
MEOX1
NCF1
NFATC3
NFATC4
PRKD1
RB1
RPS6KB1
SF3B4
SH3BP5
SHMT1
SMAD2
SMAD3
SMCO3
SSU72
TEX11
TOB1
TP53
TRAF2
TUSC2
WDR62
XPNPEP1
XPO7
ZBTB25
Entrez ID
10262
5601
HPRD ID
12028
04206
Ensembl ID
ENSG00000143368
ENSG00000050748
Uniprot IDs
B3KUJ0
Q15427
P45984
PDB IDs
1X5T
1X5U
3E7O
3NPC
Enriched GO Terms of Interacting Partners
?
RNA Processing
RNA Splicing
MRNA Processing
MRNA Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Gene Expression
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Regulation Of RNA Splicing
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Circadian Regulation Of Translation
Regulation Of Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Transcription, DNA-templated
RNA Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Cellular Response To Growth Factor Stimulus
Regulation Of ERBB Signaling Pathway
Response To Growth Factor
Negative Regulation Of Protein Metabolic Process
Immune System Process
Response To External Stimulus
Regulation Of Circadian Rhythm
Regulation Of Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Neuron Development
Posttranscriptional Regulation Of Gene Expression
Positive Regulation Of Signal Transduction
Regulation Of Cellular Process
Stress-activated MAPK Cascade
Fc Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Response To Stress
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
MAPK Cascade
Intracellular Signal Transduction
Regulation Of Kinase Activity
Apoptotic Process
Regulation Of Protein Kinase Activity
Signal Transduction By Phosphorylation
Negative Regulation Of Cellular Metabolic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of MAPK Cascade
Positive Regulation Of Cellular Biosynthetic Process
Developmental Process
Regulation Of Cellular Process
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Neuron Death
Positive Regulation Of Protein Modification Process
Positive Regulation Of Macromolecule Biosynthetic Process
Defense Response
Cellular Metabolic Process
Cellular Response To Stress
Regulation Of Signaling
Regulation Of Gene Expression
Anatomical Structure Development
Cell Differentiation
Positive Regulation Of Phosphorylation
Signal Transduction
Toll-like Receptor 4 Signaling Pathway
Immune System Process
Transcription From RNA Polymerase II Promoter
Regulation Of Catalytic Activity
Regulation Of JUN Kinase Activity
Signaling
Tagcloud
?
abeta1
autophagic
autophagosomes
autophagy
bcl2
beclin
becn1
buildup
digested
elevation
favor
favoring
flux
hamper
incompletely
jnk1
jnk2
lc3
lysosomal
mapk8
modifying
monomers
neuroblastoma
oligomers
phosphorylating
profound
sk
turn
vacuoles
Tagcloud (Difference)
?
abeta1
autophagic
autophagosomes
autophagy
bcl2
beclin
becn1
buildup
digested
elevation
favor
favoring
flux
hamper
incompletely
jnk1
jnk2
lc3
lysosomal
mapk8
modifying
monomers
neuroblastoma
oligomers
phosphorylating
profound
sk
turn
vacuoles
Tagcloud (Intersection)
?