SPRY2 and C19orf66

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPRY2	C19orf66
Gene Name		sprouty homolog 2 (Drosophila)	chromosome 19 open reading frame 66
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Plasma Membrane Microtubule Cytoskeleton Ruffle Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Epidermal Growth Factor Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Cell Fate Commitment Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Lung Growth Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Signaling by EGFR EGFR downregulation Signaling by FGFR in disease Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Spry regulation of FGF signaling Signaling by FGFR Negative regulation of FGFR signaling
Drugs
Diseases
GWAS		Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) Orofacial clefts ( 20023658 22863734) Type 2 diabetes ( 20862305)
Protein-Protein Interactions		90 interactors: ADAMTSL4 AQP1 ATRIP C19orf66 CATSPER1 CBL CBLB CBLC CHRD CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 EIF4E2 FAIM FAM219A FBN1 FRS3 GNE GP9 GPRIN2 GRAP2 GRB2 HEXIM2 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1B LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 OTX1 PACSIN3 PLSCR1 PRKAB2 PTGER3 PTPN11 RAF1 RTFDC1 RUNX1T1 SDHB SEMA5B SH3KBP1 SIAH2 SPRY1 STK16 TCAF1 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587	32 interactors: ADAMTSL4 CADPS CCDC136 DRICH1 DTNBP1 IKZF1 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 LZTS2 MAGEA1 MDFI MEOX2 MID2 MTUS2 NOTCH2NL PDE4DIP SPRY2 SSX2IP TCF4 TERF1 TNS2 TRAF1
Entrez ID		10253	55337
HPRD ID		03916	07747
Ensembl ID		ENSG00000136158	ENSG00000130813
Uniprot IDs		O43597	Q9NUL5
PDB IDs		3BUM 3OB1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Keratinization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process Keratinocyte Differentiation Regulation Of Cell Activation Negative Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Cell Death System Development Death Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Developmental Process Multicellular Organismal Development Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of T Cell Activation Cellular Response To Organic Substance Cell Differentiation Anatomical Structure Development Organ Development Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase Activity Epidermal Cell Differentiation Response To Growth Factor Protein Modification By Small Protein Conjugation Epithelium Development Regulation Of Apoptotic Process Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Kinase Activity Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process	Regulation Of Signal Transduction Developmental Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Signaling Cellular Localization Organelle Localization Cellular Component Assembly Negative Regulation Of Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Vesicle Localization Protein Complex Assembly Positive Regulation Of Neutrophil Differentiation Negative Regulation Of Signal Transduction Cellular Macromolecular Complex Assembly Anatomical Structure Development Organelle Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Kinase B Signaling Embryonic Organ Morphogenesis Negative Regulation Of Protein Localization To Nucleus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Establishment Of Organelle Localization Cellular Protein Complex Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Microtubule-based Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Telomeric Loop Formation Age-dependent Telomere Shortening Cell Cycle Establishment Of Localization In Cell Positive Regulation Of Intracellular Signal Transduction Telomere Maintenance Via Telomere Shortening Catecholamine Secretion Maintenance Of DNA Repeat Elements Negative Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Vesicle Transport Multicellular Organism Growth Regulation Of Apoptotic Process Regulation Of Cellular Process Multicellular Organismal Development Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Kinase B Signaling
Tagcloud ?		beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger
Tagcloud (Difference) ?		beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger
Tagcloud (Intersection) ?