CDK6 and CDKN2B

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		CDK6	CDKN2B
Gene Name		cyclin-dependent kinase 6	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Liver Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Transforming Growth Factor Beta Receptor Signaling Pathway Aging Negative Regulation Of Cell Proliferation Gene Expression Response To Organic Cyclic Compound Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Cellular Response To Extracellular Stimulus Cellular Response To Nutrient Response To Cytokine Negative Regulation Of Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Cellular Senescence Oncogene Induced Senescence TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer G1 Phase Senescence-Associated Secretory Phenotype (SASP) TGFBR1 KD Mutants in Cancer Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Oxidative Stress Induced Senescence SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Height ( 20881960 19343178 23563607 18391950 18391951 18391952) Rheumatoid arthritis ( 18794853) White blood cell count ( 20139978 21738479) White blood cell types ( 21738478)	Ankle-brachial index ( 22199011) Breast cancer ( 23535729 20453838) Coronary artery calcification ( 22144573 23561647) Coronary heart disease ( 21626137 21971053 17554300 21378990) Endometriosis ( 23104006) Fasting glucose-related traits (interaction with BMI) ( 22581228) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioma ( 21531791 19578367) Intracranial aneurysm ( 18997786 20364137) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 20512145) Type 2 diabetes ( 21573907 18372903 22293688 22961080 20581827 19401414 17463246 17463248 17463249 19056611) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		92 interactors: ABI2 ANKRD12 AR ATF6B ATXN1 BCL11A CASC3 CBY1 CCND1 CCND3 CDC37 CDC6 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DAB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 EZH2 FOXM1 FOXO3 HIST1H1A HSF1 ISL1 KIF26B KLF10 LPIN1 MCM10 MCM2 MEF2D MLLT3 MSL3 MYC MZF1 N4BP1 NFATC3 NIPBL NUMA1 PCNA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RB1 RBL1 RBL2 RBM23 RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 SYNPO2 TCEB3B TFDP1 TGFBR1 TJP2 TPX2 TRA2A TRA2B TRAK1 UHRF2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1	15 interactors: APP ARPC3 CCDC33 CCDC90B CDK4 CDK6 CDK8 IKBKAP ISL1 KIAA1377 MAGEA11 NIF3L1 TGFB1I1 TRAF1 ZBTB17
Entrez ID		1021	1030
HPRD ID		04533	02696
Ensembl ID		ENSG00000105810	ENSG00000147883
Uniprot IDs		A4D1G0 Q00534	K7PPU3 P42772
PDB IDs		1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cell Cycle Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process RNA Processing Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Protein Phosphorylation Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Signaling Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Protein Phosphorylation Cell Communication Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Regulation Of Kinase Activity Positive Regulation Of Fibroblast Proliferation Regulation Of Phosphorus Metabolic Process Cell Dedifferentiation Anatomical Structure Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Transcription From RNA Polymerase II Promoter Anatomical Structure Development Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Axon Guidance Positive Regulation Of Macrophage Colony-stimulating Factor Production Synaptic Growth At Neuromuscular Junction Positive Regulation Of Granulocyte Colony-stimulating Factor Production 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Pancreas Development Regulation Of Fibroblast Proliferation Forebrain Development Negative Regulation Of Cell Cycle Phosphorylation Cell Morphogenesis
Tagcloud ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		a134c abp allelic ankyrin balb cdk6 cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed