| AMPH |
amphiphysin |
- Clathrin-mediated endocytosis
|
|
|
| APP |
amyloid beta precursor protein |
- Platelet degranulation
- ECM proteoglycans
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- G alpha (q) signalling events
- G alpha (i) signalling events
- Lysosome Vesicle Biogenesis
- Formyl peptide receptors bind formyl peptides and many other ligands
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- The NLRP3 inflammasome
- Advanced glycosylation endproduct receptor signaling
- Advanced glycosylation endproduct receptor signaling
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Post-translational protein phosphorylation
- TRAF6 mediated NF-kB activation
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Purinergic signaling in leishmaniasis infection
- Amyloid fiber formation
|
- Deferoxamine
- Aluminium
- Zinc
- L-methionine (R)-S-oxide
- Resveratrol
- Tromethamine
- Phenserine
- Tetrathiomolybdate
- CAD106
- Mito-4509
- Edonerpic
- Dimercaprol
- Copper
- Florbetaben (18F)
- Florbetapir (18F)
- Flutemetamol (18F)
- Zinc acetate
- Aluminium phosphate
- Aluminum acetate
- Zinc chloride
- Zinc sulfate, unspecified form
|
|
| BCL2 |
BCL2 apoptosis regulator |
- Activation of BAD and translocation to mitochondria
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Interleukin-4 and Interleukin-13 signaling
- The NLRP1 inflammasome
- Estrogen-dependent gene expression
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
|
- Ibuprofen
- Paclitaxel
- Docetaxel
- Rasagiline
- Paclitaxel docosahexaenoic acid
- Apoptone
- Glycine betaine
- Eribulin
- Dexibuprofen
- Isosorbide
- Venetoclax
- Obatoclax
- Navitoclax
|
|
| BMPR1B |
bone morphogenetic protein receptor type 1B |
|
|
|
| CABIN1 |
calcineurin binding protein 1 |
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
|
|
|
| CSNK2B |
casein kinase 2 beta |
- Synthesis of PC
- WNT mediated activation of DVL
- Condensation of Prometaphase Chromosomes
- Signal transduction by L1
- Neutrophil degranulation
- Regulation of TP53 Activity through Phosphorylation
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
- ROS sensing by NFE2L2
- Receptor Mediated Mitophagy
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN stability and activity
|
|
|
| ENTPD4 |
ectonucleoside triphosphate diphosphohydrolase 4 |
- Phosphate bond hydrolysis by NTPDase proteins
|
|
|
| GFRA2 |
GDNF family receptor alpha 2 |
- NCAM1 interactions
- RAF/MAP kinase cascade
- RET signaling
|
|
|
| HAX1 |
HCLS1 associated protein X-1 |
|
|
|
| ITPKC |
inositol-trisphosphate 3-kinase C |
- Synthesis of IP3 and IP4 in the cytosol
|
|
|
| LEPROTL1 |
leptin receptor overlapping transcript like 1 |
|
|
|
| PPP3R1 |
protein phosphatase 3 regulatory subunit B, alpha |
- Activation of BAD and translocation to mitochondria
- DARPP-32 events
- Calcineurin activates NFAT
- Calcineurin activates NFAT
- FCERI mediated Ca+2 mobilization
- Ca2+ pathway
- CLEC7A (Dectin-1) induces NFAT activation
|
- Myristic acid
- Voclosporin
|
|
| SDC2 |
syndecan 2 |
- A tetrasaccharide linker sequence is required for GAG synthesis
- HS-GAG biosynthesis
- HS-GAG biosynthesis
- HS-GAG degradation
- Cell surface interactions at the vascular wall
- Syndecan interactions
- Syndecan interactions
- Defective B4GALT7 causes EDS, progeroid type
- Defective B3GAT3 causes JDSSDHD
- Defective EXT2 causes exostoses 2
- Defective EXT1 causes exostoses 1, TRPS2 and CHDS
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- EPHB-mediated forward signaling
- Defective B3GALT6 causes EDSP2 and SEMDJL1
- Post-translational protein phosphorylation
- Retinoid metabolism and transport
|
|
|
| SLC18A1 |
solute carrier family 18 member A1 |
- Na+/Cl- dependent neurotransmitter transporters
|
- Reserpine
- Norepinephrine
- Ephedra sinica root
- MMDA
- Metamfetamine
|
|
| SORBS3 |
sorbin and SH3 domain containing 3 |
- Smooth Muscle Contraction
|
|
|
| SPATA33 |
spermatogenesis associated 33 |
|
|
|
| TGFBR1 |
transforming growth factor beta receptor 1 |
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- UCH proteinases
- Ub-specific processing proteases
|
- 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
- Naphthyridine Inhibitor
- 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole
- N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
- 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
- N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
- Fostamatinib
|
|
| THAP7 |
THAP domain containing 7 |
|
|
|
| UNC119 |
unc-119 lipid binding chaperone |
|
|
|