COMT - HiPPIP

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
ACE	angiotensin I converting enzyme	Metabolism of Angiotensinogen to Angiotensins	Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Omapatrilat Rescinnamine Captopril Cilazapril Spirapril Epicaptopril N-acetyl-alpha-D-glucosamine Temocapril Enalaprilat Zofenopril Cilazaprilat
AQP7	aquaporin 7	Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins
AVPR2	arginine vasopressin receptor 2	Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ADORA2B mediated anti-inflammatory cytokines production	Desmopressin Vasopressin Demeclocycline Conivaptan Terlipressin M0002 OPC-51803 Tolvaptan Atosiban Lypressin
BEST2	bestrophin 2	Stimuli-sensing channels
BRS3	bombesin receptor subtype 3	Peptide ligand-binding receptors G alpha (q) signalling events
CCL4L2	C-C motif chemokine ligand 4 like 2	G alpha (i) signalling events
CDC27	cell division cycle 27	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
CDC42	cell division cycle 42	GPVI-mediated activation cascade EGFR downregulation Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation CD28 dependent Vav1 pathway EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Myogenesis Myogenesis RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	Aminophosphonic acid-guanylate ester Guanosine-5'-Diphosphate
CNR2	cannabinoid receptor 2	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Dronabinol Nabilone Ricinoleic Acid Lasofoxifene Cannabidiol Tetrahydrocannabivarin Medical Cannabis Nabiximols
CREB3L1	cAMP responsive element binding protein 3 like 1	CREB3 factors activate genes
EMD	emerin	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerisation of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
FAM209A	family with sequence similarity 209 member A
FFAR3	free fatty acid receptor 3	G alpha (q) signalling events Free fatty acid receptors
FXR2	FMR1 autosomal homolog 2
GET1	guided entry of tail-anchored proteins factor 1	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
GJB1	gap junction protein beta 1	Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly
GJB3	gap junction protein beta 3	Gap junction assembly
GJB4	gap junction protein beta 4	Gap junction assembly
GJB5	gap junction protein beta 5	Gap junction assembly
GLP1R	glucagon like peptide 1 receptor	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide
GPR152	G protein-coupled receptor 152
GPR161	G protein-coupled receptor 161	Hedgehog 'off' state Hedgehog 'on' state
GPR42	G protein-coupled receptor 42
HCK	HCK proto-oncogene, Src family tyrosine kinase	Nef and signal transduction FCGR activation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling FLT3 signaling through SRC family kinases	1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib Fostamatinib
HIBADH	3-hydroxyisobutyrate dehydrogenase	Branched-chain amino acid catabolism	NADH
HOPX	HOP homeobox
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
KCNK5	potassium two pore domain channel subfamily K member 5	Phase 4 - resting membrane potential
KRT31	keratin 31	Keratinization Formation of the cornified envelope
KRT40	keratin 40	Keratinization Formation of the cornified envelope
KRTAP5-9	keratin associated protein 5-9	Keratinization
LITAF	lipopolysaccharide induced TNF factor
MFSD14B	major facilitator superfamily domain containing 14B
MRPS5	mitochondrial ribosomal protein S5	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
MTNR1A	melatonin receptor 1A	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
MYADML2	myeloid associated differentiation marker like 2
NIPAL4	NIPA like domain containing 4	Miscellaneous transport and binding events
OTOP3	otopetrin 3
PGAP2	post-GPI attachment to proteins 2
PLPP6	phospholipid phosphatase 6	Cholesterol biosynthesis
REEP4	receptor accessory protein 4	Olfactory Signaling Pathway
RGS2	regulator of G protein signaling 2	G alpha (q) signalling events
RHBDD2	rhomboid domain containing 2
RHBDL1	rhomboid like 1
S1PR3	sphingosine-1-phosphate receptor 3	G alpha (i) signalling events Lysosphingolipid and LPA receptors Extra-nuclear estrogen signaling	Fingolimod
SELENOK	selenoprotein K
SLC10A6	solute carrier family 10 member 6	Transport of bile salts and organic acids, metal ions and amine compounds
SLC16A7	solute carrier family 16 member 7	Proton-coupled monocarboxylate transport	Pyruvic acid
SLC2A5	solute carrier family 2 member 5	Neutrophil degranulation Intestinal hexose absorption
SLC35A4	solute carrier family 35 member A4
SLC35F1	solute carrier family 35 member F1
SLC39A1	solute carrier family 39 member 1	Zinc influx into cells by the SLC39 gene family
SLC39A2	solute carrier family 39 member 2	Zinc influx into cells by the SLC39 gene family
SLC48A1	solute carrier family 48 member 1
SLC7A1	solute carrier family 7 member 1	Amino acid transport across the plasma membrane	L-Lysine Arginine Ornithine
SLC7A8	solute carrier family 7 member 8	Basigin interactions Amino acid transport across the plasma membrane	Phenylalanine Alanine
SMIM1	small integral membrane protein 1 (Vel blood group)
THSD7A	thrombospondin type 1 domain containing 7A	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
TLCD4	TLC domain containing 4
TMEM100	transmembrane protein 100
TMEM120B	transmembrane protein 120B
TMEM14B	transmembrane protein 14B
TMEM14C	transmembrane protein 14C
TMEM187	transmembrane protein 187
TMEM205	transmembrane protein 205
TMEM222	transmembrane protein 222
TMEM50A	transmembrane protein 50A
TRHR	thyrotropin releasing hormone receptor	Peptide ligand-binding receptors G alpha (q) signalling events	Protirelin
TRIP13	thyroid hormone receptor interactor 13
VAMP3	vesicle associated membrane protein 3	ER-Phagosome pathway Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
VAMP5	vesicle associated membrane protein 5
VKORC1	vitamin K epoxide reductase complex subunit 1	Metabolism of vitamin K	Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
XRN2	5'-3' exoribonuclease 2	Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
ZNF43	zinc finger protein 43	Generic Transcription Pathway

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