CDH1 and GALNT12

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		CDH1	GALNT12
Description		cadherin 1	polypeptide N-acetylgalactosaminyltransferase 12
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Beta-catenin Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Neuron Projection Development Adherens Junction Organization Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription, DNA-templated Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission	O-glycan Processing
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells	Defective GALNT12 causes colorectal cancer 1 (CRCS1) O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Colorectal cancer ( 19011631) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 32341527 26237428) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Nevus count or cutaneous melanoma ( 32341527) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Ulcerative colitis ( 19915572)	Asthma ( 31959851) Brain morphology (MOSTest) ( 32665545) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Leftâ€“right brain asymmetry ( 33723403) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824)
Interacting Genes		69 interacting genes: ACTR3 AKT1 ANAPC7 AOPEP ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC42 CDH5 CDK8 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBIN EZR FER FGFR1 FYN GALNT12 GNA12 GNA13 GSK3B HDAC1 HDAC2 HEMGN HRAS HSD17B3 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MAP2K1 MAPK3 MSANTD3 MYO6 NANS NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SFRP2 SKP2 STOML2 STX17 TMOD1 UCA1 UCHL3 VCL YES1 ZNF510	16 interacting genes: APP BMPR1A BUB1 CDH1 CDKN2A FBXW7 MLH3 MSH2 MUC1 MUC2 MUC5AC MUC7 PIK3CA PMS2 RB1 SRC
Entrez ID		999	79695
HPRD ID		01885	13561
Ensembl ID		ENSG00000039068	ENSG00000119514
Uniprot IDs		A0A0U2ZQU7 B3GN61 P12830 Q9UII7	Q8IXK2
PDB IDs		1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG 6VEL	6PXU
Enriched GO Terms of Interacting Partners?
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