NUP153 and KPNA2

Number of citations of the paper that reports this interaction (PubMedID 9275187)
24

Data Source:
HPRD (in vitro)

		NUP153	KPNA2
Description		nucleoporin 153	karyopherin subunit alpha 2
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GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Nucleolus Cytosol Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Host Cell Nuclear Pore Nuclear Basket	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane Host Cell Extrinsic Component Of Postsynaptic Specialization Membrane Glutamatergic Synapse
	Molecular Function	DNA Binding Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-membrane Adaptor Activity Metal Ion Binding	RNA Binding Protein Binding Nuclear Localization Sequence Binding Histone Deacetylase Binding Nuclear Import Signal Receptor Activity
	Biological Process	RNA Export From Nucleus Protein Import Into Nucleus Viral Entry Into Host Cell Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Viral Penetration Into Host Nucleus	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Viral Life Cycle
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Height ( 18391951) Obesity-related traits ( 23251661)	Brain morphology (MOSTest) ( 32665545) Feeling lonely ( 29500382) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)
Interacting Genes		29 interacting genes: APC BRCA1 CLK1 DTNBP1 DYNLT1 IPO5 KPNA2 KPNB1 MAPK1 MAPK14 MAPK3 MRPS5 NFX1 NUP62 NUTF2 NXF1 NXF2 PTGER4 RAN SENP2 SMAD2 SMAD3 TNPO1 TPR TRN-GTT2-7 XPO1 XPO5 XPO7 XPOT	112 interacting genes: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A ATXN3 BAG6 BRCA1 BTBD2 CASP2 CCDC107 CDA CDC42 CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCPS DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 GTF2IRD1 H1-0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MORF4L1 MVP NECAB2 NFE2L2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 OGT PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 SUMO2 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131
Entrez ID		9972	3838
HPRD ID		04899	02818
Ensembl ID		ENSG00000124789	ENSG00000182481
Uniprot IDs		P49790	P52292
PDB IDs		2EBQ 2EBR 2EBV 2GQE 4U0C 4U0D 5TSV 5TSX 6AYA	1EFX 1QGK 1QGR 3FEX 3FEY 3WPT 4E4V 4WV6 5H43
Enriched GO Terms of Interacting Partners?
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