AREL1 and NPC2

		AREL1	NPC2
Description		apoptosis resistant E3 ubiquitin protein ligase 1	NPC intracellular cholesterol transporter 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport Intermembrane Lipid Transfer
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation LDL clearance
Drugs
Diseases
GWAS		General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Mood instability ( 29187730)	Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: CRKL DIABLO HTRA2 NPC2 PIAS4 RGS6 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3	19 interacting genes: AREL1 BARD1 BRCA1 CTSW DHDDS ECT2 EIF2B2 EOLA1 ERRFI1 LIG4 PAXIP1 PDIA6 SCNN1A SCRN1 SSR1 TMED10 TRIM14 USP4 VASH1
Entrez ID		9870	10577
HPRD ID		13794	03008
Ensembl ID		ENSG00000119682	ENSG00000119655
Uniprot IDs		O15033	A0A024R6C0 P61916
PDB IDs		6JX5 6LOH	5KWY 6W5V
Enriched GO Terms of Interacting Partners?
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